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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
21
(LD)
,
OCL47
(D)
,
OCL47,48-1 (LD 21_CRS)
(D)
,
OCL47,48-2 (LD 21_P/O)
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
hypE
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Related strains
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Strains Search
|
Search strains by gene name:
hypE
Search strains by all related name:
hypE b2730 ECK2725 hydB JW2700
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General information (Go to Linear View: )
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Gene Name
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hypE
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Alternative name
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b2730,ECK2725,hydB,JW2700
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Location, Length
|
2,851,276 - 2,852,286
(
+
)
;
61.45
min
;
1011
(bp) ,
336
(aa)
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Product
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carbamoyl dehydratase, hydrogenases 1,2,3 maturation protein
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Operon Name
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hypABCDE-fhlA
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Note
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plays structural role in maturation of all 3 hydrogenases; GO_process: GO:0009061 - anaerobic respiration; GO_process: GO:0006457 - protein folding
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Function
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factor; Energy metabolism, carbon: Anaerobic respiration
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Gene Ontology
|
GO:0003824
;
catalytic activity ( hypE )
GO:0005515
;
protein binding ( hypE )
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PID
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226510967
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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HYPE_ECOLI
(
P24193
;
Q46886
)
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- Protein name
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Hydrogenase isoenzymes formation protein hypE.
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- Synonyms
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- Gene name
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Name=hypE; OrderedLocusNames=b2730;
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MMBR References
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J Biol Chem. 1994;269:19597-19604
Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli.
Hopper, S., M. Babst, V. Schlensog, H. M. Fischer, H. Hennecke, and A. Bock.
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Arch Microbiol. 1992;158(6):444-51.
The hyp operon gene products are required for the maturation of catalytically active hydrogenase isoenzymes in Escherichia coli.
Jacobi A, Rossmann R, Bock A.
(
1482271
)
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Mol Microbiol. 1991;5(1):123-35.
Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli.
Lutz S, Jacobi A, Schlensog V, Bohm R, Sawers G, Bock A.
(
1849603
)
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Mol Microbiol. 1991;5(11):2807-14.
Mechanism of regulation of the formate-hydrogenlyase pathway by oxygen, nitrate, and pH: definition of the formate regulon.
Rossmann R, Sawers G, Bock A.
(
1779767
)
|
J Bacteriol. 1988;170(12):5433-9.
Biochemical and genetic analysis of hydrogen metabolism in Escherichia coli: the hydB gene.
Sankar P, Shanmugam KT.
(
2848007
)
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| Sequences |
Amino acid
FASTA format
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0001 MNNIQLAHGS GGQAMQQLIN SLFMEAFANP WLAEQEDQAR LDLAQLVAEG DRLAFSTDSY VIDPLFFPGG
0071 NIGKLAICGT ANDVAVSGAI PRYLSCGFIL EEGLPMETLK AVVTSMAETA RAAGIAIVTG DTKVVQRGAV
0141 DKLFINTAGM GAIPANIHWG AQTLTAGDVL LVSGTLGDHG ATILNLREQL GLDGELVSDC AVLTPLIQTL
0211 RDIPGVKALR DATRGGVNAV VHEFAAACGC GIELSEAALP VKPAVRGVCE LLGLDALNFA NEGKLVIAVE
0281 RNAAEQVLAA LHSHPLGKDA ALIGEVVERK GVRLAGLYGV KRTLDLPHAE PLPRIC
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 GTAACACCTG TAATCCTCAA ACCGCGTTTG
-070 GTGCGCTGAT GGTTTCCTCC GAAGGAGCGT GCGCCGCGTG GTATCAGTAT CGTCAGCAGG AGAGTGAAGC
0001 gtgaataata tccaactcgc ccacggtagc ggcggccagg cgatgcagca attaatcaac agcctgttta
0071 tggaagcctt tgccaacccg tggctggcag agcaggaaga tcaggcacgt cttgatctgg cgcagctggt
0141 agcggaaggc gaccgtctgg cgttctccac cgacagttac gttattgacc cgctgttctt ccctggcggt
0211 aatatcggca agctggcgat ttgcggcaca gccaatgacg ttgcggtcag tggcgctatt ccgcgctatc
0281 tctcctgtgg ctttatcctc gaagaaggat tgccgatgga gacactgaaa gccgtagtga ccagcatggc
0351 agaaaccgcc cgcgcggcag gcattgccat cgttactggc gatactaaag tggtgcagcg cggcgcggta
0421 gataaactgt ttatcaacac cgctggcatg ggcgcaattc cggcgaatat tcactggggc gcacagacgc
0491 taaccgcagg cgatgtattg ctggtgagcg gtacactcgg cgaccacggg gcgactatcc ttaacctgcg
0561 tgagcagctg gggctggatg gcgaactggt cagcgactgc gcggtgctga cgccgcttat tcagacgctg
0631 cgtgacattc ccggcgtgaa agcgctgcgt gatgccaccc gtggtggtgt aaacgcggtg gttcatgagt
0701 tcgcggcagc ctgcggttgt ggtattgaac tttcagaagc ggcactgcct gttaaacctg ccgtgcgtgg
0771 cgtttgcgaa ttgctgggac tggacgccct gaactttgcc aacgaaggca aactagtaat agctgttgaa
0841 cgcaacgcgg cagagcaagt gctggcagcg ttacattccc atccactggg gaaagacgcg gcgctgattg
0911 gtgaagtggt ggaacgtaaa ggtgttcgtc ttgccggtct gtatggcgtg aaacgaaccc tcgatttacc
0981 acacgccgaa ccgcttccgc gtatatgcta aTAAAATTCT AAATCTCCTA TAGTTAGTCA ATGACCTTTT
1051 GCACCGCTTT GCGGTGCTTT CCTGGAAGAA CAAAATGTCA TATACACCGA TGAGTGATCT C
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