MG1655
W3110
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Gene Report : ccmA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Biochem J. 1998;334 (Pt 2):355-65.
Transcriptional control and essential roles of the Escherichia coli ccm gene products in formate-dependent nitrite reduction and cytochrome c synthesis.
Tanapongpipat S, Reid E, Cole JA, Crooke H. ( 9716493 )
     Deletion 14 (LD)  ,  OCL70,72-3 (LD 14B_CRS) (D)  ,  OCL70,72-4 (LD 14C_P/O) (D)  ,  OCL72 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  ccmA
Related strains
     Strains Search Search strains by gene name:  ccmA   Search strains by all related name:  ccmA b2201 ECK2193 JW5366 yejW

General information  (Go to Linear View:)
 Gene Name ccmA  
 Alternative name b2201,ECK2193,JW5366,yejW  
 Location, Length 2,295,043 - 2,295,666 (  -  ) ;   49.47 min ; 624 (bp) ,   207 (aa) Go to Linear View
 Product heme exporter subunit  
 Operon Name napFDAGHBC-ccmABCDEFGH  
 Note ATP binding protein of heme exporter A; ATP-binding component of ABC superfamily; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0017004 - cytochrome complex assembly; GO_process: GO:0006457 - protein folding  
 Function transport; Protein, peptide secretion  
 Gene Ontology GO:0000166 ; nucleotide binding ( ccmA )
GO:0005215 ; transporter activity ( ccmA )
GO:0005524 ; ATP binding ( ccmA )
GO:0005886 ; plasma membrane ( ccmA )
GO:0006810 ; transport ( ccmA )
GO:0015439 ; heme-transporting ATPase activity ( ccmA )
GO:0016020 ; membrane ( ccmA )
GO:0016787 ; hydrolase activity ( ccmA )
GO:0016887 ; ATPase activity ( ccmA )
GO:0017004 ; cytochrome complex assembly ( ccmA )
GO:0017111 ; nucleoside-triphosphatase activity ( ccmA )
GO:0030288 ; outer membrane-bounded periplasmic space ( ccmA )
 PID 87082064  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) CCMA_ECOLI ( P33931 )
    -  Protein name Cytochrome c biogenesis ATP-binding export protein ccmA  
    -  Synonyms EC 3.6.3.41, Heme exporter protein A  
    -  Gene name Name=ccmA; OrderedLocusNames=b2201;  

 Linear View (Whole Mode)
View Location
   2285.0  –  2310.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP ccmA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of The Atp-Binding Cassette Of Multisugar Transporter From Pyrococcus Horikoshii Ot3 Complexed With Atp  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Cytochrome c biogenesis ATP-binding export protein ccmA (Heme exporter protein A)  
         PSI-BLAST Methionine import ATP-binding protein metN
    nr     (database updated : 2007.02.20 )
         BLAST COG4133: ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Shigella boydii BS512]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    ABC_TRANSPORTER     

Other Cross-Reference
    COG COG4133O 
    EcoCyc ccmA 

MMBR References
Mol Microbiol. 1996;19(3):467-81.
Escherichia coli K-12 genes essential for the synthesis of c-type cytochromes and a third nitrate reductase located in the periplasm.
Grove J, Tanapongpipat S, Thomas G, Griffiths L, Crooke H, Cole J. ( 8830238 )
J Bacteriol. 1995;177:4321-4326
Escherichia coli genes required for cytochrome c maturation.
Thony-Meyer, L., F. Fischer, P. Kunzler, D. Ritz, and H. Hennecke.
FEBS Lett. 1997;410(2-3):351-5.
Escherichia coli ccm in-frame deletion mutants can produce periplasmic cytochrome b but not cytochrome c.
Throne-Holst M, Thony-Meyer L, Hederstedt L. ( 9237661 )
J Bacteriol. 1991;173(19):6139-46.
Anaerobically expressed Escherichia coli genes identified by operon fusion techniques.
Choe M, Reznikoff WS. ( 1917846 )
J Bacteriol. 1993;175:1165-1172
Identification of the regulatory sequence of anaerobically expressed locus aeg-46.5.
Choe, M., and W. S. Reznikoff.

Sequences
Amino acid
FASTA format 
0001 MGMLEARELL CERDERTLFS GLSFTLNAGE WVQITGSNGA GKTTLLRLLT GLSRPDAGEV LWQGQPLHQV 
0071 RDSYHQNLLW IGHQPGIKTR LTALENLHFY HRDGDTAQCL EALAQAGLAG FEDIPVNQLS AGQQRRVALA 
0141 RLWLTRATLW ILDEPFTAID VNGVDRLTQR MAQHTEQGGI VILTTHQPLN VAESKIRRIS LTQTRAA
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             ggtgaaagat gggcaaacct gtattgattg 
-070 ccataaaggg atagcgcaca agctgcccga tatgcgtgaa gtcgagccag gtttttaaca gggttattgc 
0001 gtgggtatgc ttgaagccag agagttactt tgtgagcggg atgaacgaac cttatttagt ggcttgtcat 
0071 ttacgctgaa cgcaggagag tgggtacaaa tcaccggtag caacggcgcg gggaagacaa cgcttctccg 
0141 tttgctgacg gggttgtctc gccctgacgc aggcgaggtt ctctggcaag ggcagccctt gcatcaggta 
0211 cgcgacagct accatcaaaa cctgttatgg ataggccatc agccggggat caaaacccgg ctgacggcgt 
0281 tagaaaatct gcacttttat catcgcgatg gcgataccgc acaatgtctg gaagccctgg cgcaggccgg 
0351 gcttgccgga ttcgaagata ttcctgtaaa tcagctctcg gccgggcaac aacgccgcgt cgctttagcg 
0421 cgtctgtggc tgacccgtgc cacgttatgg atcctcgacg agccttttac cgcgattgac gttaacggtg 
0491 tcgatcgtct gacccagcgt atggcgcagc atacggagca gggggggatt gtgattctga ctacccacca 
0561 gccgctcaac gttgctgaaa gtaaaattcg ccgcatttca ctgacgcaaa cgagggccgc atgatgttct 
0631 ggcgcatttt ccgtcttgag ctgcgtgtag cgtttcgcca tagcgccgaa atcgccaacc cgctgtggtt 
0701 cttcctgatt gtaattaccc tttt