|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCL74
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
cirA
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
cirA
Search strains by all related name:
cirA b2155 cir ECK2148 feuA JW2142
|
General information (Go to Linear View: )
|
|
Gene Name
|
cirA
|
|
Alternative name
|
b2155,cir,ECK2148,feuA,JW2142
|
|
Location, Length
|
2,242,800 - 2,244,791
(
-
)
;
48.34
min
;
1992
(bp) ,
663
(aa)
|
|
Product
|
catecholate siderophore receptor CirA
|
|
Operon Name
|
cirA
|
|
Note
|
ferric iron outer membrane transporter, TonB-dependent; surface receptor and translocator for colicin I; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0009279 - cell outer membrane
|
|
Function
|
membrane; Outer membrane constituents
|
|
Gene Ontology
|
GO:0004872
;
receptor activity ( cirA )
GO:0005215
;
transporter activity ( cirA )
GO:0005506
;
iron ion binding ( cirA )
GO:0006810
;
transport ( cirA )
GO:0006811
;
ion transport ( cirA )
GO:0006826
;
iron ion transport ( cirA )
GO:0009279
;
cell outer membrane ( cirA )
GO:0016020
;
membrane ( cirA )
GO:0019867
;
outer membrane ( cirA )
|
|
PID
|
1788478
|
EC number
(KEGG Pathway)
|
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
cirA
(
EG10155
)
|
|
Number of removed
|
25 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
CIRA_ECOLI
(
P17315
)
|
|
- Protein name
|
Colicin I receptor precursor.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=cirA; Synonyms=cir, feuA; OrderedLocusNames=b2155;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
cirA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Fhua From E. Coli
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Colicin I receptor precursor
|
|
PSI-BLAST
|
Colicin I receptor precursor
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
ferric iron-catecholate outer membrane transporter [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
RGD
TONB_DEPENDENT_REC_1
TONB_DEPENDENT_REC_2
|
|
MMBR References
|
J Bacteriol. 1987;169(12):5343-52.
Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli.
Griggs DW, Tharp BB, Konisky J.
(
3316180
)
|
Mol Gen Genet. 1984;197(1):175-81.
Mapping of markers in the gyrA-his region of Escherichia coli.
Middendorf A, Schweizer H, Vreemann J, Boos W.
(
6392823
)
|
Mol Gen Genet. 1983;191(3):401-6.
cir, a gene conferring resistance to colicin I maps between mgl and fpk on the Escherichia coli chromosome.
Boos W, Bantlow C, Benner D, Roller E.
(
6314091
)
|
J Bacteriol. 1981;145(1):647-50.
Use of cir-lac operon fusions to study transcriptional regulation of the colicin Ia receptor in Escherichia coli K-12.
Worsham PL, Konisky J.
(
7007329
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MFRLNPFVRV GLCLSAISCA WPVLAVDDDG ETMVVTASSV EQNLKDAPAS ISVITQEDLQ RKPVQNLKDV
0071 LKEVPGVQLT NEGDNRKGVS IRGLDSSYTL ILVDGKRVNS RNAVFRHNDF DLNWIPVDSI ERIEVVRGPM
0141 SSLYGSDALG GVVNIITKKI GQKWSGTVTV DTTIQEHRDR GDTYNGQFFT SGPLIDGVLG MKAYGSLAKR
0211 EKDDPQNSTT TDTGETPRIE GFSSRDGNVE FAWTPNQNHD FTAGYGFDRQ DRDSDSLDKN RLERQNYSVS
0281 HNGRWDYGTS ELKYYGEKVE NKNPGNSSPI TSESNTVDGK YTLPLTAINQ FLTVGGEWRH DKLSDAVNLT
0351 GGTSSKTSAS QYALFVEDEW RIFEPLALTT GVRMDDHETY GEHWSPRAYL VYNATDTVTV KGGWATAFKA
0421 PSLLQLSPDW TSNSCRGACK IVGSPDLKPE TSESWELGLY YMGEEGWLEG VESSVTVFRN DVKDRISISR
0491 TSDVNAAPGY QNFVGFETGA NGRRIPVFSY YNVNKARIQG VETELKIPFN DEWKLSINYT YNDGRDVSNG
0561 ENKPLSDLPF HTANGTLDWK PLALEDWSFY VSGHYTGQKR ADSATAKTPG GYTIWNTGAA WQVTKDVKLR
0631 AGVLNLGDKD LSRDDYSYNE DGRRYFMAVD YRF
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 aaaaataagt ccaccgcgat gctgccgtac
-070 gcaaggggac gtgaagaaga tgtgagcgat aacccatttt attttcgtag ttacctcatg gagatatgga
0001 atgtttaggt tgaacccttt cgtacgggtc gggctgtgtt tgtccgctat ttcttgtgca tggcctgtgt
0071 tagcggtcga tgatgatggc gaaacgatgg ttgtcactgc atcttccgtg gaacaaaatc ttaaagatgc
0141 acctgccagt atcagcgtca ttacccagga agacctgcag cgaaaaccgg tacagaatct gaaggatgtc
0211 ctcaaagaag tgcctggcgt acaactgacg aacgaagggg ataaccgtaa gggcgttagt attcgtggtc
0281 tggacagcag ctataccctg attctcgtcg acggtaaacg cgtgaactcc cgcaatgccg tcttccgcca
0351 caatgatttc gatctgaact ggatcccggt cgattccatc gaacgtattg aagtggtccg tggcccgatg
0421 tcgtcgctgt acggttccga tgcgctcggc ggtgtagtga atatcatcac caaaaaaatc ggtcagaaat
0491 ggtcgggtac cgttaccgtc gataccacca ttcaggaaca tcgcgatcgc ggtgacacct ataacggtca
0561 gttctttacc agtggaccat taattgatgg tgtgctggga atgaaagctt acggcagcct ggcaaaacgt
0631 gaaaaggatg acccgcaaaa ctcaacgacc accgataccg gagaaacgcc gcgtattgaa ggattctcca
0701 gccgcgacgg caatgtcgaa tttgcctgga caccgaatca aaatcacgat tttactgccg gatacggttt
0771 cgaccgtcag gatcgtgatt ccgactcgct ggacaaaaac cgcctggaac gccagaacta ctccgtcagc
0841 cataatgggc gttgggatta cggcaccagc gaactgaaat actacggtga gaaagtcgag aacaaaaacc
0911 ctggcaacag cagcccgata acttccgaaa gcaatacggt cgacggcaaa tacacgttgc cgctgacggc
0981 gattaatcag tttctcacgg ttggcggtga atggcgtcac gacaaactta gcgatgcggt gaacctgacc
1051 gggggaacca gctccaaaac gtctgccagc cagtacgcgc tgtttgtgga agatgaatgg cggatcttcg
1121 agccgctggc gctgacgacc ggcgtgcgta tggacgatca cgaaacctac ggtgaacact ggagtccgcg
1191 tgcctacctg gtttataacg ccaccgacac cgtaacggtg aaagggggct gggcgacggc atttaaagca
1261 ccttctctgt tgcaacttag ccctgactgg acgagcaatt cctgccgtgg cgcatgtaag attgtgggta
1331 gcccggatct gaaaccagaa accagcgaaa gttgggagct ggggctttac tacatgggtg aagaaggctg
1401 gctggaaggg gttgaatcca gcgttaccgt tttccgtaac gatgtgaaag atcgtatcag catcagccgt
1471 acgtctgacg tcaacgctgc accgggctac caaaactttg ttggttttga gacgggcgct aacggacggc
1541 gcataccggt atttagctac tacaacgtta acaaagctcg tattcagggc gtggaaaccg aactgaaaat
1611 tccgttcaac gatgaatgga aactgtcgat caactacacc tacaacgatg gtcgtgatgt cagcaacggc
1681 gaaaacaaac cgctatccga tctgccgttc catactgcta acggtacgct ggactggaaa ccgctggcgc
1751 tggaagactg gtcattctat gtttctgggc actataccgg gcagaaacgc gccgacagcg cgacggctaa
1821 aacaccgggc ggttatacca tctggaatac cggcgcggcc tggcaggtga ctaaagacgt caaactgcgc
1891 gcaggcgtgc tgaaccttgg cgacaaggat ctcagtcgtg acgactacag ctataacgaa gacggacgtc
1961 gttactttat ggcagtggat tatcgcttct gatgagaaga tgcccggcga accgggcgga ctttcacttc
2031 agtaaatact gcgcatggaa gcgcaggtga tcctctataa aagaggcgat gaagtagtaa ct
|
