MG1655
W3110
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Gene Report : btuC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL85,86-8 (AK4-4 / BK6-4) (D)  ,  OCL86 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  btuC
Related strains
     Strains Search Search strains by gene name:  btuC   Search strains by all related name:  btuC b1711 ECK1709 JW1701

General information  (Go to Linear View:)
 Gene Name btuC  
 Alternative name b1711,ECK1709,JW1701  
 Location, Length 1,792,196 - 1,793,176 (  -  ) ;   38.63 min ; 981 (bp) ,   326 (aa) Go to Linear View
 Product vitamin B12 transporter subunit: membrane component of ABC superfamily  
 Operon Name btuCED  
 Note vitamin B12 transport permease protein; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane  
 Function transport; Transport of small molecules: Other  
 Gene Ontology GO:0005215 ; transporter activity ( btuC )
GO:0005886 ; plasma membrane ( btuC )
GO:0006810 ; transport ( btuC )
GO:0015235 ; cobalamin transporter activity ( btuC )
GO:0015889 ; cobalamin transport ( btuC )
GO:0016020 ; membrane ( btuC )
GO:0016021 ; integral to membrane ( btuC )
 PID 1788004  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) BTUC_ECOLI ( P06609 ; P77197 )
    -  Protein name Vitamin B12 transport system permease protein btuC.  
    -  Synonyms  
    -  Gene name Name=btuC; OrderedLocusNames=b1711;  

 Linear View (Whole Mode)
View Location
   1780.0  –  1805.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP btuC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Bacterial Abc Transporter Involved In B12 Uptake  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Vitamin B12 import system permease protein btuC  
         PSI-BLAST Vitamin B12 import system permease protein btuC
    nr     (database updated : 2007.02.20 )
         BLAST vitamin B12 transport permease protein [Shigella sonnei Ss046]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    LEUCINE_ZIPPER     

Other Cross-Reference
    COG COG4139H 
    EcoCyc btuC 

MMBR References
J Bacteriol. 1986;167(3):920-7.
Identification of the btuCED polypeptides and evidence for their role in vitamin B12 transport in Escherichia coli.
de Veaux LC, Clevenson DS, Bradbeer C, Kadner RJ. ( 3528128 )
J Bacteriol. 1985;162(3):888-96.
Transport of vitamin B12 in Escherichia coli: cloning of the btuCD region.
DeVeaux LC, Kadner RJ. ( 2987192 )
J Bacteriol. 1986;167(3):928-34.
Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems.
Friedrich MJ, de Veaux LC, Kadner RJ. ( 3528129 )

Sequences
Amino acid
FASTA format
0001 MLTLARQQQR QNIRWLLCLS VLMLLALLLS LCAGEQWISP GDWFTPRGEL FVWQIRLPRT LAVLLVGAAL 
0071 AISGAVMQAL FENPLAEPGL LGVSNGAGVG LIAAVLLGQG QLPNWALGLC AIAGALIITL ILLRFARRHL 
0141 STSRLLLAGV ALGIICSALM TWAIYFSTSV DLRQLMYWMM GGFGGVDWRQ SWLMLALIPV LLWICCQSRP 
0211 MNMLALGEIS ARQLGLPLWF WRNVLVAATG WMVGVSVALA GAIGFIGLVI PHILRLCGLT DHRVLLPGCA 
0281 LAGASALLLA DIVARLALAA AELPIGVVTA TLGAPVFIWL LLKAGR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             tctgatctaa ctaaaaaggc cgctctgcgg 
-070 ccttttttct tttcactgtc gaagagtcac cgtaaaatca acgccatgac acttcagcag aacggatacc 
0001 atgctgacac ttgcccgcca acaacagcga caaaatattc gctggttatt atgcctgtca gttttgatgc 
0071 tgctggcgct tctcttaagc ctttgcgccg gtgaacaatg gatctcgcca ggtgactggt ttactcctcg 
0141 tggcgaactg ttcgtctggc aaattcgcct gccacgtacg ctggctgtat tgctggttgg tgcggcgctg 
0211 gctatatccg gcgctgtaat gcaggcgttg tttgaaaatc ctctggcaga acctggacta cttggcgtct 
0281 ctaacggcgc aggcgtgggg cttatcgccg cggtattgct tgggcaaggg caactcccca actgggcgct 
0351 agggctgtgt gcgattgctg gcgcgcttat catcacttta atactcttac gtttcgcccg tcgtcatctt 
0421 tcgaccagtc ggttattgct ggctggcgtt gcattaggga ttatctgtag cgcactaatg acgtgggcta 
0491 tctacttttc cacctcagtt gatttgcgtc agctgatgta ctggatgatg ggcggttttg gcggcgtaga 
0561 ctggcggcaa agctggctga tgctggcatt gatccccgtg ttgttgtgga tctgttgtca gtccaggccg 
0631 atgaatatgt tagcacttgg cgagatctcg gcgcggcaac tgggtttacc cctgtggttc tggcgcaatg 
0701 tgctggtggc agcgaccggc tggatggttg gcgtcagtgt ggcgctggcg ggtgctatcg gctttattgg 
0771 tctggtgatc ccccatattc tccggttgtg tggtttaacc gatcatcgcg tattacttcc cggctgcgcg 
0841 ctggcagggg cgagcgcatt gctgctggcc gatattgtag cgcgcctggc attagctgcc gcagagctgc 
0911 ctattggcgt ggtcaccgca acgttaggtg cgccggtgtt tatctggtta ttgttaaaag caggacgtta 
0981 gccgcaaaaa gacggtctat gattaaaagc taagattttt actgaccaca cccaggagaa acgatgcaag 
1051 attccattct gacgaccgta gtgaaagata t