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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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OCR64
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
icd
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Related strains
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Strains Search
|
Search strains by gene name:
icd
Search strains by all related name:
icd b1136 ECK1122 icdA icdE JW1122
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General information (Go to Linear View: )
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Gene Name
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icd
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Alternative name
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b1136,ECK1122,icdA,icdE,JW1122
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Location, Length
|
1,194,346 - 1,195,596
(
+
)
;
25.74
min
;
1251
(bp) ,
416
(aa)
|
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Product
|
e14 prophage; isocitrate dehydrogenase, specific for NADP+
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Operon Name
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icd
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Note
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isocitrate dehydrogenase, specific for NADP+; GO_process: GO:0006099 - tricarboxylic acid cycle; GO_process: GO:0009061 - anaerobic respiration
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Function
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enzyme; Energy metabolism, carbon: TCA cycle; Phage or Prophage Related
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Gene Ontology
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GO:0000287
;
magnesium ion binding ( icd )
GO:0004450
;
isocitrate dehydrogenase (NADP+) activity ( icd )
GO:0006097
;
glyoxylate cycle ( icd )
GO:0006099
;
tricarboxylic acid cycle ( icd )
GO:0008152
;
metabolic process ( icd )
GO:0016491
;
oxidoreductase activity ( icd )
GO:0016616
;
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ( icd )
GO:0030145
;
manganese ion binding ( icd )
GO:0046872
;
metal ion binding ( icd )
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PID
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1787381
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EC number
(KEGG Pathway)
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1.1.1.42
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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IDH_ECOLI
(
P08200
)
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- Protein name
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Isocitrate dehydrogenase [NADP]
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- Synonyms
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EC 1.1.1.42, Oxalosuccinate decarboxylase, IDH, NADP+-specific ICDH, IDP
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- Gene name
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Name=icd; Synonyms=icdA, icdE; OrderedLocusNames=b1136;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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icd
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain , Isocitrate Dehydrogenase (E.C.1.1.1.42)
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Isocitrate dehydrogenase [NADP]
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PSI-BLAST
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Isocitrate dehydrogenase [NADP]
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nr
(database updated :
2007.02.20
)
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BLAST
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isocitrate dehydrogenase [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
IDH_IMDH
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MMBR References
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Curr Microbiol. 1982;7:45-47.
Genetic map position of the cistron coding for isocitrate dehydrogenase in Escherichia coli K-12.
Apostolakos, D., P. A. Menter, B. J. Rampsch, H. C. Reeves, and E. A. Birge.
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J Bacteriol. 1971;105(3):1224-6.
Nalidixic acd-resistant mutants of Escherichia coli deficient in isocitrate dehydrogenase.
Helling RB, Kukora JS.
(
4926678
)
|
J Bacteriol. 1990;172(12):6618
Location of icdA and fadR on the physical map of Escherichia coli.
Herold C, Birge EA.
(
2254241
)
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J Bacteriol. 1989;171(7):4083-4.
Use of the isocitrate dehydrogenase structural gene for attachment of e14 in Escherichia coli K-12.
Hill CW, Gray JA, Brody H.
(
2661545
)
|
Genetica. 1992;86(1-3):259-67.
Lambdoid phages as elements of bacterial genomes (integrase/phage21/Escherichia coli K-12/icd gene).
Campbell A, Schneider SJ, Song B.
(
1468648
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MESKVVVPAQ GKKITLQNGK LNVPENPIIP YIEGDGIGVD VTPAMLKVVD AAVEKAYKGE RKISWMEIYT
0071 GEKSTQVYGQ DVWLPAETLD LIREYRVAIK GPLTTPVGGG IRSLNVALRQ ELDLYICLRP VRYYQGTPSP
0141 VKHPELTDMV IFRENSEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP CSEEGTKRLV
0211 RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR EEFGGELIDG GPWLKVKNPN TGKEIVIKDV
0281 IADAFLQQIL LRPAEYDVIA CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK
0351 VNPGSIILSA EMMLRHMGWT EAADLIVKGM EGAINAKTVT YDFERLMDGA KLLKCSEFGD AIIENM
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TTAACAAAAA ATTGCTCTAA AGCATCCGTA
-070 TCGCAGGACG CAAACGCATA TGCAACGTGG TGGCAGACGA GCAAACCAGT AGCGCTCGAA GGAGAGGTGA
0001 atggaaagta aagtagttgt tccggcacaa ggcaagaaga tcaccctgca aaacggcaaa ctcaacgttc
0071 ctgaaaatcc gattatccct tacattgaag gtgatggaat cggtgtagat gtaaccccag ccatgctgaa
0141 agtggtcgac gctgcagtcg agaaagccta taaaggcgag cgtaaaatct cctggatgga aatttacacc
0211 ggtgaaaaat ccacacaggt ttatggtcag gacgtctggc tgcctgctga aactcttgat ctgattcgtg
0281 aatatcgcgt tgccattaaa ggtccgctga ccactccggt tggtggcggt attcgctctc tgaacgttgc
0351 cctgcgccag gaactggatc tctacatctg cctgcgtccg gtacgttact atcagggcac tccaagcccg
0421 gttaaacacc ctgaactgac cgatatggtt atcttccgtg aaaactcgga agacatttat gcgggtatcg
0491 aatggaaagc agactctgcc gacgccgaga aagtgattaa attcctgcgt gaagagatgg gggtgaagaa
0561 aattcgcttc ccggaacatt gtggtatcgg tattaagccg tgttcggaag aaggcaccaa acgtctggtt
0631 cgtgcagcga tcgaatacgc aattgctaac gatcgtgact ctgtgactct ggtgcacaaa ggcaacatca
0701 tgaagttcac cgaaggagcg tttaaagact ggggctacca gctggcgcgt gaagagtttg gcggtgaact
0771 gatcgacggt ggcccgtggc tgaaagttaa aaacccgaac actggcaaag agatcgtcat taaagacgtg
0841 attgctgatg cattcctgca acagatcctg ctgcgtccgg ctgaatatga tgttatcgcc tgtatgaacc
0911 tgaacggtga ctacatttct gacgccctgg cagcgcaggt tggcggtatc ggtatcgccc ctggtgcaaa
0981 catcggtgac gaatgcgccc tgtttgaagc cacccacggt actgcgccga aatatgccgg tcaggacaaa
1051 gtaaatcctg gctctattat tctctccgct gagatgatgc tgcgccacat gggttggacc gaagcggctg
1121 acttaattgt taaaggtatg gaaggcgcaa tcaacgcgaa aaccgtaacc tatgacttcg agcgtctgat
1191 ggatggcgct aaactgctga aatgttcaga gtttggtgac gcgatcatcg aaaacatgta aTGCCGTAGT
1261 TTGTTAAATT TATTAACGGG AGCGTAACGC TCCCGTTGTT TTTTGTTAGG CTGCTAACGG TTATCAAAAT
1331 TTTATCAAAA AAAGTTATCA A
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