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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCR04
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
metR
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Related strains
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Strains Search
|
Search strains by gene name:
metR
Search strains by all related name:
metR b3828 ECK3822 f317 JW3804
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General information (Go to Linear View: )
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Gene Name
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metR
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Alternative name
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b3828,ECK3822,f317,JW3804
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Location, Length
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4,009,886 - 4,010,839
(
-
)
;
86.43
min
;
954
(bp) ,
317
(aa)
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Product
|
DNA-binding transcriptional activator, homocysteine-binding
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Operon Name
|
metR
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Note
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regulator for metE and metH; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0009086 - methionine biosynthetic process; GO_process: GO:0006350 - transcription
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Function
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regulator; Amino acid biosynthesis: Methionine
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Gene Ontology
|
GO:0003677
;
DNA binding ( metR )
GO:0003700
;
transcription factor activity ( metR )
GO:0005737
;
cytoplasm ( metR )
GO:0006350
;
transcription ( metR )
GO:0006355
;
regulation of transcription, DNA-dependent ( metR )
GO:0008652
;
amino acid biosynthetic process ( metR )
GO:0009086
;
methionine biosynthetic process ( metR )
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PID
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1790262
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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metR
(
EG10591
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
|
METR_ECOLI
(
P19797
)
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- Protein name
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HTH-type transcriptional regulator metR.
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- Synonyms
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- Gene name
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Name=metR; OrderedLocusNames=b3828, z5349, ECs4758, SF3906, S3849;
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MMBR References
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Proc Natl Acad Sci U S A. 1989;86:85-89
Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes.
Maxon, M. E., B. Redfield, X. Y. Cai, R. Shoeman, K. Fujita, W. Fisher, Stauffer, H. Weissbach, and N. Brot.
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J Bacteriol. 1987;169(4):1391-7.
A new methionine locus, metR, that encodes a trans-acting protein required for activation of metE and metH in Escherichia coli and Salmonella typhimurium.
Urbanowski ML, Stauffer LT, Plamann LS, Stauffer GV.
(
3549685
)
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Mol Microbiol. 1991;5(7):1593-7.
Regulation of methionine synthesis in Escherichia coli.
Weissbach H, Brot N.
(
1943695
)
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Proc Natl Acad Sci U S A. 1989;86:4407-4411
Methionine synthesis in Escherichia coli: effect of the MetR protein on metE and metH expression.
Cai, X. Y., M. E. Maxon, B. Redfield, R. Glass, N. Brot, and H. Weissbach.
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Science. 1992;257(5071):771-8.
Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.
Daniels DL, Plunkett G 3rd, Burland VD, Blattner FR.
(
1379743
)
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| Sequences |
Amino acid
FASTA format
|
0001 MIEVKHLKTL QALRNCGSLA AAAATLHQTQ SALSHQFSDL EQRLGFRLFV RKSQPLRFTP QGEILLQLAN
0071 QVLPQISQAL QACNEPQQTR LRIAIECHSC IQWLTPALEN FHKNWPQVEM DFKSGVTFDP QPALQQGELD
0141 LVMTSDILPR SGLHYSPMFD YEVRLVLAPD HPLAAKTRIT PEDLASETLL IYPVQRSRLD VWRHFLQPAG
0211 VSPSLKSVDN TLLLIQMVAA RMGIAALPHW VVESFERQGL VVTKTLGEGL WSRLYAAVRD GEQRQPVTEA
0281 FIRSARNHAC DHLPFVKSAE RPTYDAPTVR PGSPARL
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gacgaaggat tttagccgtc cagatgttta
-070 cacatccata attggcggtt actgtatatt cctcaagcgc aaattattca tgccgaagtg aaggactttc
0001 atgatcgaag taaaacacct gaaaacgcta caagcgttgc ggaactgcgg ctcgctcgca gccgctgcgg
0071 cgacgttgca tcagacgcaa tccgccctgt ctcaccagtt tagcgatctg gaacaacgcc ttggcttccg
0141 gctatttgtg cgtaagagcc agccgctacg ctttacaccg cagggagaaa tcctgttgca actggcaaac
0211 caggtactgc cgcaaattag ccaggccctg caagcctgca atgaaccgca gcagacgcgt ctgcgcattg
0281 ccattgagtg ccatagctgt attcagtggc tgacacccgc gttagaaaat ttccataaga actggccgca
0351 ggtagagatg gattttaaat cgggcgtgac atttgacccg cagcccgcct tgcaacaggg agagctggat
0421 ctggtaatga cgtccgatat tctgccgcgc agtggcctgc attattcgcc gatgttcgac tatgaagtgc
0491 gtctggtgtt agcacctgac catccactgg cggcgaaaac gcgaattaca ccggaagatc tcgccagcga
0561 gacgctatta atttatccgg tgcagcgtag tcgactggat gtctggcggc attttcttca gccggcaggc
0631 gtcagcccgt cactgaaaag cgtcgataac accttattgt tgattcagat ggttgccgcg cggatgggta
0701 ttgccgcgct accgcattgg gtagtagaga gttttgagcg ccagggtctg gtggtgacca aaaccctggg
0771 cgaaggcttg tggagccgac tgtacgccgc cgtgcgcgat ggcgagcagc gtcagccagt tacggaagcg
0841 tttattcgct cagcgcgcaa tcacgcctgc gatcatctgc cgtttgtgaa gagcgcggag cgacccactt
0911 acgatgcacc cacagtgagg ccaggatcac cagcgcgcct gtaataaacg ttggccagtg cggctgttgg
0981 tgccagatag ccaggtttac cagcagccct gccggaacgt gcatattatt cataatgccc agcgttccgg
1051 cgtc
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