MG1655
W3110
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Gene Report : pdxH
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  pdxH
Related strains
     Strains Search Search strains by gene name:  pdxH   Search strains by all related name:  pdxH b1638 ECK1634 JW1630

General information  (Go to Linear View:)
 Gene Name pdxH  
 Alternative name b1638,ECK1634,JW1630  
 Location, Length 1,715,375 - 1,716,031 (  -  ) ;   36.97 min ; 657 (bp) ,   218 (aa) Go to Linear View
 Product pyridoxine 5'-phosphate oxidase  
 Operon Name pdxH-tyrS-pdxY  
 Note pyridoxinephosphate oxidase; GO_process: GO:0008615 - pyridoxine biosynthetic process  
 Function enzyme; Biosynthesis of cofactors, carriers: Pyridoxine  
 Gene Ontology GO:0004733 ; pyridoxamine-phosphate oxidase activity ( pdxH )
GO:0008615 ; pyridoxine biosynthetic process ( pdxH )
GO:0010181 ; FMN binding ( pdxH )
GO:0016491 ; oxidoreductase activity ( pdxH )
 PID 1787926  
 EC number
  (KEGG Pathway)
 
1.4.3.5  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene pdxH ( EG11487 )  
    Number of removed 1 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PDXH_ECOLI ( P28225 )
    -  Protein name Pyridoxamine 5'-phosphate oxidase  
    -  Synonyms EC 1.4.3.5, PNP/PMP oxidase, PNPOx  
    -  Gene name Name=pdxH; OrderedLocusNames=b1638, SF1663, S1795;  

 Linear View (Whole Mode)
View Location
   1705.0  –  1730.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP pdxH (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, X-Ray Structure Of Escherichia Coli Pyridoxine 5'-Phosphate Oxidase Complexed With Pyridoxal 5'-Phosphate At 2.0 A Resolution  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (PNPOx)  
         PSI-BLAST Pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (PNPOx)
    nr     (database updated : 2007.02.20 )
         BLAST pyridoxamine 5'-phosphate oxidase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    PYRIDOX_OXIDASE     

Other Cross-Reference
    COG COG0259H 
    EcoCyc pdxH 

MMBR References
J Bacteriol. 1971;107(2):580-2.
Identification of the forms of vitamin B 6 present in the culture media of "vitamin B 6 control" mutants.
Dempsey WB, Arcement LJ. ( 4939769 )
Arch Microbiol. 1988;150(4):363-7.
Temperature-sensitive murein synthesis in an Escherichia coli pdx mutant and the role of alanine racemase.
Grogan DW. ( 3060037 )
Mol Gen Genet. 1984;196(2):367-72.
Genetic characterization of the Escherichia coli cyclopropane fatty acid (cfa) locus and neighboring loci.
Grogan DW, Cronan JE Jr. ( 6092874 )
J Bacteriol. 1992;174:6033-6045
Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations.
Lam, H. M., and M. E. Winkler.
J Bacteriol. 1976;127(3):1593-4.
Genetic map position of the pdxH gene in Escherichia coli.
Shimizu S, Dempsey WB. ( 783152 )

Sequences
Amino acid
FASTA format
0001 MSDNDELQQI AHLRREYTKG GLRRRDLPAD PLTLFERWLS QACEAKLADP TAMVVATVDE HGQPYQRIVL 
0071 LKHYDEKGMV FYTNLGSRKA HQIENNPRVS LLFPWHTLER QVMVIGKAER LSTLEVMKYF HSRPRDSQIG 
0141 AWVSKQSSRI SARGILESKF LELKQKFQQG EVPLPSFWGG FRVSLEQIEF WQGGEHRLHD RFLYQRENDA 
0211 WKIDRLAP

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             atcgtcttga ataactgtca gttacaaaat 
-070 ccacagcgtt gagatttttc caggggcggc gcacaatagc gtcacccact gacaatccgt aaagaaaacc 
0001 atgtctgata acgacgaatt gcagcaaatc gcgcatctgc gccgtgaata caccaaaggc gggttacgcc 
0071 gccgcgatct tcccgccgat ccattaaccc tttttgaacg ttggctctct caggcttgtg aagccaaact 
0141 ggcggaccct accgcgatgg tggtcgctac cgtggatgaa catggtcagc cttatcagcg catcgtttta 
0211 ctcaaacatt acgacgaaaa aggcatggtg ttttacacca acctcggcag ccgtaaagca catcaaatcg 
0281 aaaataatcc gcgcgttagc ctgctgttcc cgtggcatac ccttgagcgc caggtgatgg tgatcggtaa 
0351 agcagaacga ctttcgactc tcgaagtgat gaaatatttt catagccgcc cgcgtgatag ccagattggt 
0421 gcatgggttt cgaagcagtc cagtcgcatt tctgcccgcg gtatccttga aagtaaattc ctggagctga 
0491 agcagaagtt tcaacagggc gaagtgccat tgccgagctt ttggggcggt tttcgcgtca gccttgaaca 
0561 gattgagttc tggcagggtg gtgagcatcg cctgcatgac cgctttttgt accagcgtga aaatgatgcg 
0631 tggaagattg atcgtcttgc accctgaaaa gatgcaaaaa tcttgcttta atcgctggta ctcctgattc 
0701 tggcacttta ttctatgtct ctttcgcatc tggcgaaaag tcgtgtaccg gcaaagg