|
PEC Original Annotations
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|
Essentiality
|
|
Class
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non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCL64
(D)
,
OCL64-10
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
pdxB
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
pdxB
Search strains by all related name:
pdxB b2320 ECK2314 JW2317
|
General information (Go to Linear View: )
|
|
Gene Name
|
pdxB
|
|
Alternative name
|
b2320,ECK2314,JW2317
|
|
Location, Length
|
2,434,737 - 2,435,873
(
-
)
;
52.48
min
;
1137
(bp) ,
378
(aa)
|
|
Product
|
erythronate-4-phosphate dehydrogenase
|
|
Operon Name
|
pdxB-usg-truA-dedA
|
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Note
|
erythronate-4-phosphate dehyrogenase; GO_process: GO:0008615 - pyridoxine biosynthetic process
|
|
Function
|
enzyme; Biosynthesis of cofactors, carriers: Pyridoxine
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( pdxB )
GO:0005488
;
binding ( pdxB )
GO:0005737
;
cytoplasm ( pdxB )
GO:0008152
;
metabolic process ( pdxB )
GO:0008615
;
pyridoxine biosynthetic process ( pdxB )
GO:0016491
;
oxidoreductase activity ( pdxB )
GO:0016616
;
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ( pdxB )
GO:0033711
;
4-phosphoerythronate dehydrogenase activity ( pdxB )
GO:0048037
;
cofactor binding ( pdxB )
GO:0051287
;
NAD binding ( pdxB )
|
|
PID
|
1788660
|
EC number
(KEGG Pathway)
|
1.1.1.-
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PDXB_ECOLI
(
P05459
)
|
|
- Protein name
|
Erythronate-4-phosphate dehydrogenase
|
|
- Synonyms
|
EC 1.1.1.-
|
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- Gene name
|
Name=pdxB; OrderedLocusNames=b2320;
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Homology Analysis
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BLAST
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Bacteria
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|
GTOP
|
pdxB
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Human 3-Phosphoglycerate Dehydrogenase
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Erythronate-4-phosphate dehydrogenase
|
|
PSI-BLAST
|
Ketol-acid reductoisomerase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
erythronate-4-phosphate dehydrogenase [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
RGD
D_2_HYDROXYACID_DH_1
D_2_HYDROXYACID_DH_3
|
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MMBR References
|
J Bacteriol. 1971;107(2):580-2.
Identification of the forms of vitamin B 6 present in the culture media of "vitamin B 6 control" mutants.
Dempsey WB, Arcement LJ.
(
4939769
)
|
J Bacteriol. 1987;169(3):1071-9.
An unusual genetic link between vitamin B6 biosynthesis and tRNA pseudouridine modification in Escherichia coli K-12.
Arps PJ, Winkler ME.
(
3029017
)
|
J Bacteriol. 1987;169(3):1061-70.
Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette.
Arps PJ, Winkler ME.
(
3029016
)
|
J Bacteriol. 1989;171(11):6084-92.
Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12.
Schoenlein PV, Roa BB, Winkler ME.
(
2681152
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKILVDENMP YARDLFSRLG EVTAVPGRPI PVAQLADADA LMVRSVTKVN ESLLAGKPIK FVGTATAGTD
0071 HVDEAWLKQA GIGFSAAPGC NAIAVVEYVF SSLLMLAERD GFSLYDRTVG IVGVGNVGRR LQARLEALGI
0141 KTLLCDPPRA DRGDEGDFRS LDELVQRADI LTFHTPLFKD GPYKTLHLAD EKLIRSLKPG AILINACRGA
0211 VVDNTALLTC LNEGQKLSVV LDVWEGEPEL NVELLKKVDI GTSHIAGYTL EGKARGTTQV FEAYSKFIGH
0281 EQHVALDTLL PAPEFGRITL HGPLDQPTLK RLVHLVYDVR RDDAPLRKVA GIPGEFDKLR KNYLERREWS
0351 SLYVICDDAS AASLLCKLGF NAVHHPAR
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 attacgtatc cttatacctg aaatcttcgc
-070 aagtatgcct ggccgcgaga ttatggcaca cttgtccggt taactctcgt ctcatacagg taacacaaac
0001 gtgaaaatcc ttgttgatga aaatatgcct tatgcccgcg acttatttag ccgtttgggt gaggtgaccg
0071 cggttcccgg gcgtccaatc cccgtcgctc aactggcaga cgcggatgcg ctgatggtgc gttcggtcac
0141 gaaagtgaat gaatctttgc tggcaggaaa acccattaaa tttgttggca ctgccactgc ggggaccgac
0211 catgtcgatg aagcatggtt gaagcaggcg ggaattggtt tttccgctgc acctggctgt aatgcgattg
0281 cggtggtgga atatgttttc tcctccctgc tgatgcttgc cgaacgcgat ggattttcac tgtacgaccg
0351 tacggtgggg atcgtgggcg ttggtaacgt tggacgtcga ttgcaggcgc gactggaagc gttagggatt
0421 aaaaccttac tttgcgatcc gcctcgcgcc gaccgtgggg atgagggtga tttccgctcg ctggatgagt
0491 tagtccagcg cgcggatatt ctgactttcc atacgccact ctttaaagat ggtccgtaca aaacgctaca
0561 tctggcggat gaaaaactga tccgtagcct gaagcccgga gcgattctga ttaacgcctg ccgtggcgca
0631 gtcgtcgata atactgcgtt gctgacctgc ctgaatgaag gccagaagtt aagcgtagtg ctggatgtct
0701 gggaaggcga accggaactc aacgtcgagc tgctgaaaaa agtggatatc ggcacgtcgc atatcgcagg
0771 ctataccctg gaaggtaaag cacgcggtac tacgcaagtg tttgaagctt atagcaagtt tattgggcat
0841 gaacagcacg ttgcgctgga tacattactg cctgcgccag agtttggtcg cattacgctg catggcccgc
0911 tcgatcaacc gacgctgaaa aggctggtgc atttggtgta tgatgtgcgc cgcgatgacg caccgctgcg
0981 taaagtcgcc gggataccgg gtgagttcga taaactgcgc aaaaactatc ttgagcgccg tgaatggtca
1051 tctctgtatg taatttgtga tgacgccagt gcggcatcat tgctgtgtaa actgggtttt aacgccgttc
1121 atcatccggc acgttaatct cttcttcatg ctctctgctg taacattggc agggagcttt gctatttctg
1191 gagtaaacca ccatgtctga aggctggaac attgccgtcc tgggcgc
|
