|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
J Bacteriol. 1998;180(16):4294-9.
Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.
Yang Y, Zhao G, Man TK, Winkler ME.
(
9696782
)
|
|
|
Deletion
|
OCL40
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
epd
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
epd
Search strains by all related name:
epd b2927 ECK2923 gapB JW2894
|
General information (Go to Linear View: )
|
|
Gene Name
|
epd
|
|
Alternative name
|
b2927,ECK2923,gapB,JW2894
|
|
Location, Length
|
3,070,694 - 3,071,713
(
-
)
;
66.18
min
;
1020
(bp) ,
339
(aa)
|
|
Product
|
D-erythrose 4-phosphate dehydrogenase
|
|
Operon Name
|
epd-pgk-fbaA
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0008615 - pyridoxine biosynthetic process; GO_process: GO:0006094 - gluconeogenesis
|
|
Function
|
enzyme; Central intermediary metabolism
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( epd )
GO:0004365
;
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity ( epd )
GO:0005488
;
binding ( epd )
GO:0005515
;
protein binding ( epd )
GO:0005737
;
cytoplasm ( epd )
GO:0006096
;
glycolysis ( epd )
GO:0008152
;
metabolic process ( epd )
GO:0008615
;
pyridoxine biosynthetic process ( epd )
GO:0016491
;
oxidoreductase activity ( epd )
GO:0042823
;
pyridoxal phosphate biosynthetic process ( epd )
GO:0048001
;
erythrose-4-phosphate dehydrogenase activity ( epd )
GO:0051287
;
NAD binding ( epd )
|
|
PID
|
1789295
|
EC number
(KEGG Pathway)
|
1.2.1.9
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
epd
(
EG10368
)
|
|
Number of removed
|
1 aa cleaved
|
|
SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
E4PD_ECOLI
(
P11603
)
|
|
- Protein name
|
D-erythrose-4-phosphate dehydrogenase
|
|
- Synonyms
|
EC 1.2.1.-, E4PDH
|
|
- Gene name
|
OrderedLocusNames=b2927, c3505, z4266, ECs3798, SF2911.1, S3112;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
epd
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain O, Crsytal Structure Of Human Liver Gapdh
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
D-erythrose-4-phosphate dehydrogenase (E4PDH)
|
|
PSI-BLAST
|
Glyceraldehyde-3-phosphate dehydrogenase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
D-erythrose 4-phosphate dehydrogenase [Escherichia coli CFT073]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
GAPDH
|
|
MMBR References
|
Proc Natl Acad Sci U S A. 1996;93:5641-5646
A functional peptide encoded in the Escherichia coli 23S rRNA.
Tenson, T., A. DeBlasio, and A. Mankin.
|
| Sequences |
Amino acid
FASTA format
|
0001 MTVRVAINGF GRIGRNVVRA LYESGRRAEI TVVAINELAD AAGMAHLLKY DTSHGRFAWE VRQERDQLFV
0071 GDDAIRVLHE RSLQSLPWRE LGVDVVLDCT GVYGSREHGE AHIAAGAKKV LFSHPGSNDL DATVVYGVNQ
0141 DQLRAEHRIV SNASCTTNCI IPVIKLLDDA YGIESGTVTT IHSAMHDQQV IDAYHPDLRR TRAASQSIIP
0211 VDTKLAAGIT RFFPQFNDRF EAIAVRVPTI NVTAIDLSVT VKKPVKANEV NLLLQKAAQG AFHGIVDYTE
0281 LPLVSVDFNH DPHSAIVDGT QTRVSGAHLI KTLVWCDNEW GFANRMLDTT LAMATVAFR
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 accaatcagt cgcagtttgc gacaggtaag
-070 gtttccccgg acgatttgct ggattactct gtctggcaaa tttgctcagg gaaaaccttg caggagatct
0001 atgaccgtac gcgtagcgat aaatggcttc ggtcgcatcg ggcgtaatgt ggttcgtgct ttgtatgaat
0071 ccggacgccg ggcggaaatt accgtggtgg caatcaacga actggcggat gctgcgggca tggcgcattt
0141 gttgaaatat gacaccagcc atggccgttt tgcatgggaa gtacgacagg aacgcgatca actttttgtt
0211 ggtgatgacg ccatccgcgt attgcatgaa cgttcactgc aatcgctccc ctggcgtgaa cttggcgttg
0281 atgtagtcct cgactgcacc ggcgtatatg gctcccgcga gcatggcgaa gcgcatattg ccgccggggc
0351 caaaaaagtg ctcttttcac atcctggcag taacgatctc gacgcgaccg ttgtttacgg cgtcaatcag
0421 gatcaacttc gtgcggaaca ccgcatcgtt tctaacgctt cctgtaccac gaattgcata attcccgtca
0491 tcaaattgtt agatgatgcg tacggtattg agtccggcac tgtgaccaca attcactccg ccatgcacga
0561 tcaacaggtt attgatgcat accatcctga cctgcgtcgc acccgggcag ccagccagtc gatcattccg
0631 gtcgatacta aactggccgc cggtatcaca cgattttttc cgcaatttaa cgatcgcttt gaagcgattg
0701 cggtacgtgt gccaaccata aatgtgacgg caatcgattt aagcgtgacg gtgaagaaac ctgtaaaagc
0771 caatgaagtc aacctgttgc tgcaaaaagc agcacaaggt gcatttcatg gtatagttga ctatacggaa
0841 ttgccgttgg tctctgtaga ttttaaccac gatccgcaca gtgccattgt cgatggcacc caaacccggg
0911 tcagtggcgc acacctgatc aaaacgttgg tctggtgcga taacgaatgg ggctttgcta accgaatgct
0981 cgacacgacg ttagctatgg ctactgttgc tttcaggtaa gacgcaagca gcgtctgcaa aacttttaga
1051 atcaacgaga ggattcacca tgtctgtaat taagatgacc gatctggatc ttgctgggaa acgtgtattt
|
