MG1655
W3110
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Gene Report : lpxC
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
J Bacteriol. 1987;169(12):5408-15.
Sequence analysis, transcriptional organization, and insertional mutagenesis of the envA gene of Escherichia coli.
Beall B, Lutkenhaus J. ( 2824434 )
     Deletion OCR30,31-3 (BK2-1 / AK1-1) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  lpxC
Related strains
     Strains Search Search strains by gene name:  lpxC   Search strains by all related name:  lpxC asmB b0096 ECK0097 envA JW0094

General information  (Go to Linear View:)
 Gene Name lpxC  
 Alternative name asmB,b0096,ECK0097,envA,JW0094  
 Location, Length 106,557 - 107,474 (  +  ) ;   2.30 min ; 918 (bp) ,   305 (aa) Go to Linear View
 Product UDP-3-O-acyl N-acetylglucosamine deacetylase  
 Operon Name mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC  
 Note UDP-3-O-acyl N-acetylglucosamine deacetylase; lipid A biosynthesis; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0042280 - cell surface antigen activity, host-interacting; GO_process: GO:0009245 - lipid A biosynthetic process  
 Function enzyme; Surface polysaccharides & antigens  
 Gene Ontology GO:0008610; lipid biosynthetic process ( lpxC )
GO:0008759; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity ( lpxC )
GO:0009245; lipid A biosynthetic process ( lpxC )
GO:0016787; hydrolase activity ( lpxC )
 PID 1786285  
 EC number
  (KEGG Pathway)
 
3.5.1.-  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene lpxC ( EG10265 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) LPXC_ECOLI ( P07652 )
    -  Protein name UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase  
    -  Synonyms EC 3.5.1.-, UDP-3-O-acyl-GlcNAc deacetylase, envA protein  
    -  Gene name OrderedLocusNames=b0096, c0114, z0106, ECs0100, SF0093, S0095;  

 Linear View (Whole Mode)
View Location
   95.0  –  120.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP lpxC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Rdc Refined Solution Structure Of The AalpxcTU-514 Complex  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (Protein envA)  
         PSI-BLAST UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (Protein envA)
    nr     (database updated : 2007.02.20 )
         BLAST UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION     

Other Cross-Reference
    EcoCyc lpxC 

MMBR References
J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M. ( 2553679 )
J Bacteriol. 1996;178:5138-5143
asmB, a suppressor locus for assembly-defective OmpF mutants of Escherichia coli, is allelic to envA (lpxC).
Kloser, A. W., M. W. Laird, and R. Misra.
J Bacteriol. 1987;169(12):5408-15.
Sequence analysis, transcriptional organization, and insertional mutagenesis of the envA gene of Escherichia coli.
Beall B, Lutkenhaus J. ( 2824434 )
J Bacteriol. 1980;142(2):615-20.
Organization of genes in the ftsA-envA region of the Escherichia coli genetic map and identification of a new fts locus (ftsZ).
Lutkenhaus JF, Wolf-Watz H, Donachie WD. ( 6991482 )
J Bacteriol. 1980;143(3):1281-8.
Determination of transcriptional units and gene products from the ftsA region of Escherichia coli.
Lutkenhaus JF, Wu HC. ( 6447690 )
Curr Microbiol. 1980;4:51-55.
Mutations affecting the regulation of gamma-aminobutyrate utilization in Escherichia coli K-12.
Metzer, E., and Y. S. Halpern.
J Bacteriol. 1987;169(9):4163-70.
Cluster of genes controlling synthesis and activation of 2,3-dihydroxybenzoic acid in production of enterobactin in Escherichia coli.
Nahlik MS, Fleming TP, McIntosh MA. ( 3040680 )
Microbiol. Rev. 1993;57:655-682
Genetics of lipopolysaccharide biosynthesis in enteric bacteria.
Schnaitman, C. A., and J. D. Klena.
J Biol Chem. 1996;271:258-263
Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis.
Sorensen, P. G., J. Lutkenhaus, K. Young, S. S. Eveland, M. S. Anderson, and C. R. Raetz.
J Bacteriol. 1984;160(2):724-32.
Transcriptional organization within an Escherichia coli cell division gene cluster: direction of transcription of the cell separation gene envA.
Sullivan NF, Donachie WD. ( 6094489 )
J Biol Chem. 1995;270:30384-30391
The envA permeability/cell division gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase.
Young, K., L. L. Silver, D. Bramhill, P. Cameron, S. S. Eveland, C. R. Raetz, S. A. Hyland, and M. S. Anderson.

Sequences
Amino acid
FASTA format
0001 MIKQRTLKRI VQATGVGLHT GKKVTLTLRP APANTGVIYR RTDLNPPVDF PADAKSVRDT MLCTCLVNEH 
0071 DVRISTVEHL NAALAGLGID NIVIEVNAPE IPIMDGSAAP FVYLLLDAGI DELNCAKKFV RIKETVRVED 
0141 GDKWAEFKPY NGFSLDFTID FNHPAIDSSN QRYAMNFSAD AFMRQISRAR TFGFMRDIEY LQSRGLCLGG 
0211 SFDCAIVVDD YRVLNEDGLR FEDEFVRHKM LDAIGDLFMC GHNIIGAFTA YKSGHALNNK LLQAVLAKQE 
0281 AWEYVTFQDD AELPLAFKAP SAVLA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GAATTGACTG GAATTTGGGT TTCGAGGCTC 
-070 TTTGTGCTAA ACTGGCCCGC CGAATGTATA GTACACTTCG GTTGGATAGG TAATTTGGCG AGATAATACG 
0001 atgatcaaac aaaggacact taaacgtatc gttcaggcga cgggtgtcgg tttacatacc ggcaagaaag 
0071 tcaccctgac gttacgccct gcgccggcca acaccggggt catctatcgt cgcaccgact tgaatccacc 
0141 ggtagatttc ccggccgatg ccaaatctgt gcgtgatacc atgctctgta cgtgtctggt caacgagcat 
0211 gatgtacgga tttcaaccgt agagcacctc aatgctgctc tcgcgggctt gggcatcgat aacattgtta 
0281 tcgaagttaa cgcgccggaa atcccgatca tggacggcag cgccgctccg tttgtatacc tgctgcttga 
0351 cgccggtatc gacgagttga actgcgccaa aaaatttgtt cgcatcaaag agactgttcg tgtcgaagat 
0421 ggcgataagt gggctgaatt taagccgtac aatggttttt cgctggattt caccatcgat tttaaccatc 
0491 cggctattga ttccagcaac cagcgctatg cgatgaactt ctccgctgat gcgtttatgc gccagatcag 
0561 ccgtgcgcgt acgttcggtt tcatgcgtga tatcgaatat ctgcagtccc gtggtttgtg cctgggcggc 
0631 agcttcgatt gtgccatcgt tgttgacgat tatcgcgtac tgaacgaaga cggcctgcgt tttgaagacg 
0701 aatttgtgcg tcacaaaatg ctcgatgcga tcggtgactt gttcatgtgt ggtcacaata ttattggtgc 
0771 atttaccgct tataaatccg gtcatgcact gaataacaaa ctgctgcagg ctgtcctggc gaaacaggaa 
0841 gcctgggaat atgtgacctt ccaggacgac gcagaactgc cgttggcctt caaagcgcct tcagctgtac 
0911 tggcataaCG ACATTTATAC TGTCGTATAA AATTCGACTG GCAAATCTGG CACTCTCTCC GGCCAGGTGA 
0981 ACCAGTCGTT TTTTTTTGAA TTTTATAAGA GCTATAAA