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PEC Original Annotations
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Essentiality
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Class
|
essential
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References (PMID)
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J Bacteriol. 1983;154(2):554-60.
Role for fadR in unsaturated fatty acid biosynthesis in Escherichia coli.
Nunn WD, Giffin K, Clark D, Cronan JE Jr.
(
6341354
)
|
|
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Deletion
|
OCR56
(D)
,
OCR56-7
(D)
,
OCR56-8
(D)
|
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
fabA
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Related strains
|
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Strains Search
|
Search strains by gene name:
fabA
Search strains by all related name:
fabA b0954 ECK0945 JW0937
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General information (Go to Linear View: )
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Gene Name
|
fabA
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Alternative name
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b0954,ECK0945,JW0937
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Location, Length
|
1,015,175 - 1,015,693
(
-
)
;
21.88
min
;
519
(bp) ,
172
(aa)
|
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Product
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beta-hydroxydecanoyl thioester dehydrase
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Operon Name
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fabA
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Note
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beta-hydroxydecanoyl thioester dehydrase, trans-2-decenoyl-ACP isomerase
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Function
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enzyme; Fatty acid and phosphatidic acid biosynthesis
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Gene Ontology
|
GO:0003824
;
catalytic activity ( fabA )
GO:0005737
;
cytoplasm ( fabA )
GO:0006633
;
fatty acid biosynthetic process ( fabA )
GO:0008610
;
lipid biosynthetic process ( fabA )
GO:0008693
;
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity ( fabA )
GO:0009058
;
biosynthetic process ( fabA )
GO:0016829
;
lyase activity ( fabA )
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PID
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1787187
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EC number
(KEGG Pathway)
|
4.2.1.59
|
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
|
fabA
(
EG10273
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
|
FABA_ECOLI
(
P18391
;
Q59383
)
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- Protein name
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3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
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- Synonyms
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EC 4.2.1.60, Beta-hydroxydecanoyl thioester dehydrase
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- Gene name
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Name=fabA; OrderedLocusNames=b0954, z1304, ECs1038, SF0954, S1020;
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MMBR References
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J Biol Chem. 1973;248:1188-1195
An estimate of the minimum amount of unsaturated fatty acid required for growth of Escherichia coli.
Cronan, J. E., Jr., and E. P. Gelmann.
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J Biol Chem. 1988;263:4641-4646
Derived amino acid sequence and identification of active site residues of Escherichia coli beta-hydroxydecanoyl thioester dehydrase.
Cronan, J. E., Jr., W.-B. Li, R. Coleman, M. Narasimhan, D. de Mendoza, and J. M. Schwab.
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| Sequences |
Amino acid
FASTA format
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0001 MVDKRESYTK EDLLASGRGE LFGAKGPQLP APNMLMMDRV VKMTETGGNF DKGYVEAELD INPDLWFFGC
0071 HFIGDPVMPG CLGLDAMWQL VGFYLGWLGG EGKGRALGVG EVKFTGQVLP TAKKVTYRIH FKRIVNRRLI
0141 MGLADGEVLV DGRLIYTASD LKVGLFQDTS AF
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 tacgttggct gaactggttt attccgaact
-070 gatcggactt gttcagcgta cacgtgttag ctatcctgcg tgcttcaata aaataaggct tacagagaac
0001 atggtagata aacgcgaatc ctatacaaaa gaagaccttc ttgcctctgg tcgcggtgaa ctgtttggcg
0071 ctaaaggccc gcaattgcca gcaccgaaca tgctgatgat ggaccgtgtg gtcaaaatga ccgaaacggg
0141 tggtaacttc gacaaagggt atgttgaagc agaactggat atcaatccgg atctgtggtt cttcggatgc
0211 cactttattg gcgatccggt tatgccggga tgcctgggcc tggacgcaat gtggcagctg gtagggttct
0281 acctcggctg gctgggcggc gaaggtaaag gccgcgcgct gggcgttggc gaagtgaaat tcactggtca
0351 ggtactgccg acagcgaaaa aagtgaccta ccgtattcac tttaaacgca ttgttaaccg tcgtctgatt
0421 atgggcctgg cggatggcga agtgctggtt gatggtcgtc tgatctatac cgccagcgac ctgaaagtcg
0491 gtctgttcca ggatacgtct gccttctgat tataatcaga cagagtatca aaaggcgaaa cctccgcaat
0561 gcggaggttt ctttttaaag agacagaatc aggccattac taccctgtcc gccatggct
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