MG1655
W3110
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Gene Report : ftsW
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Mol Microbiol. 1997;24(6):1263-73.
ftsW is an essential cell-division gene in Escherichia coli.
Boyle DS, Khattar MM, Addinall SG, Lutkenhaus J, Donachie WD. ( 9218774 )
     Deletion OCR30,31-3 (BK2-1 / AK1-1) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  ftsW
Related strains
     Strains Search Search strains by gene name:  ftsW   Search strains by all related name:  ftsW b0089 ECK0090 JW0087

General information  (Go to Linear View:)
 Gene Name ftsW  
 Alternative name b0089,ECK0090,JW0087  
 Location, Length 98,403 - 99,647 (  +  ) ;   2.12 min ; 1245 (bp) ,   414 (aa) Go to Linear View
 Product lipid II flippase; integral membrane protein involved in stabilizing FstZ ring during cell division  
 Operon Name mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC  
 Note cell division; membrane protein involved in shape determination; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane  
 Function membrane; Cell division  
 Gene Ontology GO:0005886; plasma membrane ( ftsW )
GO:0007047; cell wall organization and biogenesis ( ftsW )
GO:0007049; cell cycle ( ftsW )
GO:0008360; regulation of cell shape ( ftsW )
GO:0009252; peptidoglycan biosynthetic process ( ftsW )
GO:0016020; membrane ( ftsW )
GO:0016021; integral to membrane ( ftsW )
GO:0051301; cell division ( ftsW )
 PID 1786277  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) FTSW_ECOLI ( P16457 )
    -  Protein name Cell division protein ftsW.  
    -  Synonyms  
    -  Gene name Name=ftsW; OrderedLocusNames=b0089, c0107, z0099, ECs0093;  

 Linear View (Whole Mode)
View Location
   90.0  –  115.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP ftsW (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
        PSI-BLAST  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Cell division protein ftsW  
         PSI-BLAST Cell division protein ftsW
    nr     (database updated : 2007.02.20 )
         BLAST Cell division protein ftsW [Escherichia coli CFT073]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION    PHOSPHOPANTETHEINE    FTSW_RODA_SPOVE     

Other Cross-Reference
    EcoCyc ftsW 

MMBR References
J Bacteriol. 1989;171(11):6375-8.
Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.
Ikeda M, Sato T, Wachi M, Jung HK, Ishino F, Kobayashi Y, Matsuhashi M. ( 2509435 )
J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M. ( 2553679 )
J Bacteriol. 1994;176:7140-7147
Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli.
Khattar, M. M., K. J. Begg, and W. D. Donachie.
J Bacteriol. 1997;179:784-793
Two polypeptide products of the Escherichia coli cell division gene ftsW and a possible role for FtsW in FtsZ function.
Khattar, M. M., S. G. Addinall, K. H. Stedul, D. S. Boyle, J. Lutkenhaus, and W. D. Donachie.

Sequences
Amino acid
FASTA format
0001 MRLSLPRLKM PRLPGFSILV WISTALKGWV MGSREKDTDS LIMYDRTLLW LTFGLAAIGF IMVTSASMPI 
0071 GQRLTNDPFF FAKRDGVYLI LAFILAIITL RLPMEFWQRY SATMLLGSII LLMIVLVVGS SVKGASRWID 
0141 LGLLRIQPAE LTKLSLFCYI ANYLVRKGDE VRNNLRGFLK PMGVILVLAV LLLAQPDLGT VVVLFVTTLA 
0211 MLFLAGAKLW QFIAIIGMGI SAVVLLILAE PYRIRRVTAF WNPWEDPFGS GYQLTQSLMA FGRGELWGQG 
0281 LGNSVQKLEY LPEAHTDFIF AIIGEELGYV GVVLALLMVF FVAFRAMSIG RKALEIDHRF SGFLACSIGI 
0351 WFSFQALVNV GAAAGMLPTK GLTLPLISYG GSSLLIMSTA IMMLLRIDYE TRLEKAQAFV RGSR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             ATATGGTTCT GCTCTCCCCA GCCTGTGCCA 
-070 GCCTTGATCA GTTCAAGAAC TTTGAACAAC GAGGCAATGA GTTTGCCCGT CTGGCGAAGG AGTTAGGTTG 
0001 atgcgtttat ctctccctcg cctgaaaatg ccgcgcctgc caggattcag tatcctggtc tggatctcca 
0071 cggcgctaaa gggctgggtg atgggctcgc gggaaaaaga taccgacagc ctgatcatgt acgatcgcac 
0141 cttactgtgg ctgaccttcg gcctcgcggc gattggcttt atcatggtga cctcggcgtc aatgcccata 
0211 gggcaacgct taaccaacga tccgttcttc ttcgcgaagc gtgatggtgt ctatctgatt ttggcgttta 
0281 ttctggcgat cattacgctg cgtctgccga tggagttctg gcaacgctac agtgccacga tgctgctcgg 
0351 atctatcatc ctgctgatga tcgtcctggt agtgggtagc tcggttaaag gggcatcgcg ttggatcgat 
0421 ctcggtttgc tgcgtatcca gcctgcggag ctgacaaaac tgtcgctgtt ttgctatatc gccaactatc 
0491 tggtgcgtaa aggcgacgaa gtacgtaata acctgcgcgg cttcctgaaa ccgatgggcg tgattctggt 
0561 gttggcagtg ttactgctgg cacagccaga ccttggtacg gtggtggtgt tgtttgtgac tacgctggcg 
0631 atgttgttcc tggcgggagc gaaattgtgg cagttcattg ccattatcgg tatgggcatt tcagcggttg 
0701 tgttgctgat actcgccgaa ccgtaccgta tccgccgtgt taccgcattc tggaacccgt gggaagatcc 
0771 ctttggcagc ggctatcagt taacgcaatc gctgatggcg tttggtcgcg gcgaactttg ggggcaaggt 
0841 ttaggtaact cggtacaaaa actggagtat ctgccggaag cgcacactga ctttattttc gccattatcg 
0911 gcgaagaact ggggtatgtc ggtgtggtgc tggcactttt aatggtattc ttcgtcgctt ttcgcgcgat 
0981 gtcgattggc cgtaaagcat tagaaattga ccaccgtttt tccggttttc tcgcctgttc tattggcatc 
1051 tggtttagct tccaggcgct ggttaacgta ggcgcggcgg cggggatgtt accgaccaaa ggtctgacat 
1121 tgccgctgat cagttacggt ggttcgagct tactgattat gtcgacagcc atcatgatgc tgttgcgtat 
1191 tgattatgaa acgcgtctgg agaaagcgca ggcgtttgta cgaggttcac gatgaGTGGT CAAGGAAAGC 
1261 GATTAATGGT GATGGCAGGC GGAACCGGTG GACATGTATT CCCGGGACTG GCGGTTGCGC ACCATCTAAT 
1331 GGCTCAGGGT TGGCA