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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1973;113(3):1096-103.
Isolation and characterization of a regulatory mutant of an aminoacyl-transfer ribonucleic acid synthetase in Escherichia coli K-12.
Clarke SJ, Low B, Konigsberg W.
(
4570769
)
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Deletion
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OCR51,52-1
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
serS
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Related strains
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Strains Search
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Search strains by gene name:
serS
Search strains by all related name:
serS b0893 ECK0884 JW0876
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General information (Go to Linear View: )
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Gene Name
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serS
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Alternative name
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b0893,ECK0884,JW0876
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Location, Length
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938,651 - 939,943
(
+
)
;
20.23
min
;
1293
(bp) ,
430
(aa)
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Product
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seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine
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Operon Name
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serS
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Note
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serine tRNA synthetase; also charges selenocystein tRNA with serine; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006418 - tRNA aminoacylation for protein translation
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Function
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enzyme; Aminoacyl tRNA synthetases, tRNA modification
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Gene Ontology
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GO:0000166
;
nucleotide binding ( serS )
GO:0001514
;
selenocysteine incorporation ( serS )
GO:0004812
;
aminoacyl-tRNA ligase activity ( serS )
GO:0004828
;
serine-tRNA ligase activity ( serS )
GO:0005524
;
ATP binding ( serS )
GO:0005737
;
cytoplasm ( serS )
GO:0006412
;
translation ( serS )
GO:0006418
;
tRNA aminoacylation for protein translation ( serS )
GO:0006434
;
seryl-tRNA aminoacylation ( serS )
GO:0016874
;
ligase activity ( serS )
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PID
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1787120
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EC number
(KEGG Pathway)
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6.1.1.11
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
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SYS_ECOLI
(
P09156
)
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- Protein name
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Seryl-tRNA synthetase
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- Synonyms
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EC 6.1.1.11, Serine--tRNA ligase, SerRS
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- Gene name
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OrderedLocusNames=b0893, c1030, z1239, ECs0978, SF0852, S0893;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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serS
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain A, Seryl-Trna Synthetase (E.C.6.1.1.11)
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Seryl-tRNA synthetase (Serine--tRNA ligase) (SerRS)
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PSI-BLAST
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Seryl-tRNA synthetase
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nr
(database updated :
2007.02.20
)
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BLAST
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COG0172: Seryl-tRNA synthetase [Escherichia coli E110019]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
PROKAR_LIPOPROTEIN
AA_TRNA_LIGASE_II_1
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MMBR References
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Nucleic Acids Res. 1987;15:1005-1017
Cloning and characterization of the gene for Escherichia coli seryl-tRNA synthetase.
Hartlein, M., D. Madern, and R. Leberman.
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J Bacteriol. 1971;106(3):972-82.
Biochemical bases for the antimetabolite action of L-serine hydroxamate.
Tosa T, Pizer LI.
(
4934072
)
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| Sequences |
Amino acid
FASTA format
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0001 MLDPNLLRNE PDAVAEKLAR RGFKLDVDKL GALEERRKVL QVKTENLQAE RNSRSKSIGQ AKARGEDIEP
0071 LRLEVNKLGE ELDAAKAELD ALQAEIRDIA LTIPNLPADE VPVGKDENDN VEVSRWGTPR EFDFEVRDHV
0141 TLGEMHSGLD FAAAVKLTGS RFVVMKGQIA RMHRALSQFM LDLHTEQHGY SENYVPYLVN QDTLYGTGQL
0211 PKFAGDLFHT RPLEEEADTS NYALIPTAEV PLTNLVRGEI IDEDDLPIKM TAHTPCFRSE AGSYGRDTRG
0281 LIRMHQFDKV EMVQIVRPED SMAALEEMTG HAEKVLQLLG LPYRKIILCT GDMGFGACKT YDLEVWIPAQ
0351 NTYREISSCS NVWDFQARRM QARCRSKSDK KTRLVHTLNG SGLAVGRTLV AVMENYQQAD GRIEVPEVLR
0421 PYMNGLEYIG
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CTACCGTTAA TGTTATCGTT GCGGTAATGT
-070 TGTTACTGTA TCCCTGTGGT CGCAGGCTGT GGCCACATCT CCCATTTAAT TCGATAAGCA CAGGATAAGC
0001 atgctcgatc ccaatctgct gcgtaatgag ccagacgcag tcgctgaaaa actggcacgc cggggcttta
0071 agctggatgt agataagctg ggcgctcttg aagagcgtcg taaagtattg caggtcaaaa cggaaaacct
0141 gcaagcggag cgtaactccc gatcgaaatc cattggccag gcgaaagcgc gcggggaaga tatcgagcct
0211 ttacgtctgg aagtgaacaa actgggcgaa gagctggatg cagcaaaagc cgagctggat gctttacagg
0281 ctgaaattcg cgatatcgcg ctgaccatcc ctaacctgcc tgcagatgaa gtgccggtag gtaaagacga
0351 aaatgacaac gttgaagtca gccgctgggg taccccgcgt gagtttgact ttgaagttcg tgaccacgtg
0421 acgctgggtg aaatgcactc tggcctcgac tttgcagctg cagttaagct gactggttcc cgctttgtgg
0491 taatgaaagg gcagattgct cgcatgcacc gcgcactgtc gcagtttatg ctggatctgc ataccgaaca
0561 gcatggctac agtgagaact atgttccgta cctggttaac caggacacgc tgtacggtac gggtcaactg
0631 ccgaaatttg ctggcgatct gttccatact cgtccgctgg aagaagaagc agacaccagt aactatgcgc
0701 tgatcccaac ggcagaagtt ccgctgacta acctggtgcg cggtgaaatc atcgatgaag atgatctgcc
0771 aattaagatg accgcccaca ccccatgctt ccgttctgaa gccggttcat atggtcgtga cacccgtggt
0841 ctgatccgta tgcaccagtt cgacaaagtt gaaatggtgc agatcgtgcg cccagaagac tcaatggcgg
0911 cgctggaaga gatgactggt catgcagaaa aagtcctgca gttgctgggc ctgccgtacc gtaaaatcat
0981 cctttgcact ggcgacatgg gctttggcgc ttgcaaaact tacgacctgg aagtatggat cccggcacag
1051 aacacctacc gtgagatctc ttcctgctcc aacgtttggg atttccaggc acgtcgtatg caggcacgtt
1121 gccgcagcaa gtcggacaag aaaacccgtc tggttcatac cctgaacggt tctggtctgg ctgttggtcg
1191 tacgctggtt gcagtaatgg aaaactatca gcaggctgat ggtcgtattg aagtaccaga agttctgcgt
1261 ccgtatatga acggactgga atatattggc taaTACCCAA TTTTTCTGAA TCTAAAAAGC GCCTGCGGGC
1331 GCTTTTTTTG TCTCCCTTTG ATACCGAACA ATAATTACTC CTCACTTACA CGTAATACTA CTT
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