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PEC Original Annotations
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|
Essentiality
|
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Class
|
non-essential
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|
References (PMID)
|
Gene. 1995;159(2):203-7.
Functional antibody single-chain fragments from the cytoplasm of Escherichia coli: influence of thioredoxin reductase (TrxB).
Proba K, Ge L, Pluckthun A.
(
7622050
)
|
|
|
Deletion
|
OCR50
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
trxB
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
trxB
Search strains by all related name:
trxB b0888 ECK0879 JW0871
|
General information (Go to Linear View: )
|
|
Gene Name
|
trxB
|
|
Alternative name
|
b0888,ECK0879,JW0871
|
|
Location, Length
|
930,308 - 931,273
(
-
)
;
20.05
min
;
966
(bp) ,
321
(aa)
|
|
Product
|
thioredoxin reductase, FAD/NAD(P)-binding
|
|
Operon Name
|
trxB
|
|
Note
|
thioredoxin reductase; GO_component: GO:0005737 - cytoplasm
|
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Function
|
enzyme; 2'-Deoxyribonucleotide metabolism
|
|
Gene Ontology
|
GO:0004791
;
thioredoxin-disulfide reductase activity ( trxB )
GO:0005515
;
protein binding ( trxB )
GO:0005737
;
cytoplasm ( trxB )
GO:0006118
;
electron transport ( trxB )
GO:0016491
;
oxidoreductase activity ( trxB )
GO:0019430
;
removal of superoxide radicals ( trxB )
GO:0050660
;
FAD binding ( trxB )
|
|
PID
|
1787114
|
EC number
(KEGG Pathway)
|
1.8.1.9
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
trxB
(
EG11032
)
|
|
Number of removed
|
1 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
TRXB_ECOLI
(
P09625
)
|
|
- Protein name
|
Thioredoxin reductase
|
|
- Synonyms
|
EC 1.8.1.9, TRXR
|
|
- Gene name
|
Name=trxB; OrderedLocusNames=b0888, z1232, ECs0973;
|
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MMBR References
|
J Bacteriol. 1992;174(11):3824-5.
Physical map locations of the trxB, htrD, cydC, and cydD genes of Escherichia coli.
Delaney JM, Georgopoulos C.
(
1317384
)
|
J Bacteriol. 1984;159(3):1060-2.
Mapping of trxB, a mutation responsible for reduced thioredoxin reductase activity.
Haller BL, Fuchs JA.
(
6090385
)
|
J Bacteriol. 1985;163(1):238-42.
Direct cloning of the trxB gene that encodes thioredoxin reductase.
Russel M, Model P.
(
2989245
)
|
In A. Holmgren (ed.), Thioredoxin and glutaredoxin systems. Raven Press, New York, N.Y. 1986:331
Direct cloning of the trxB gene: role of thioredoxin reductase in filamentous phage assembly.
Russel, M., and P. Model.
|
J Biol Chem. 1988;263:9015-9019
Sequence of thioredoxin reductase from Escherichia coli. Relationship to other flavoprotein disulfide oxidoreductases.
Russel, M., and P. Model.
|
| Sequences |
Amino acid
FASTA format
|
0001 MGTTKHSKLL ILGSGPAGYT AAVYAARANL QPVLITGMEK GGQLTTTTEV ENWPGDPNDL TGPLLMERMH
0071 EHATKFETEI IFDHINKVDL QNRPFRLNGD NGEYTCDALI IATGASARYL GLPSEEAFKG RGVSACATCD
0141 GFFYRNQKVA VIGGGNTAVE EALYLSNIAS EVHLIHRRDG FRAEKILIKR LMDKVENGNI ILHTNRTLEE
0211 VTGDQMGVTG VRLRDTQNSD NIESLDVAGL FVAIGHSPNT AIFEGQLELE NGYIKVQSGI HGNATQTSIP
0281 GVFAAGDVMD HIYRQAITSA GTGCMAALDA ERYLDGLADA K
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ccgattgcac aaattgttaa caaaatcgtc
-070 atactctttt tttacgtctg taaattccct acaatcctgc ccattgtctg ccaacaacta tggggatctc
0001 atgggcacga ccaaacacag taaactgctt atcctgggtt caggcccggc gggatacacc gctgctgtct
0071 acgcggcgcg cgccaacctg caacctgtgc tgattaccgg catggaaaaa ggcggccaac tgaccaccac
0141 cacggaagtg gaaaactggc ctggcgatcc aaacgatctg accggtccgt tattaatgga gcgcatgcac
0211 gaacatgcca ccaagtttga aactgagatc atttttgatc atatcaacaa ggtggatctg caaaaccgtc
0281 cgttccgtct gaatggcgat aacggcgaat acacttgcga cgcgctgatt attgccaccg gagcttctgc
0351 acgctatctc ggcctgccct ctgaagaagc ctttaaaggc cgtggggttt ctgcttgtgc aacctgcgac
0421 ggtttcttct atcgcaacca gaaagttgcg gtcatcggcg gcggcaatac cgcggttgaa gaggcgctgt
0491 atctgtctaa catcgcttcg gaagtgcatc tgattcaccg ccgtgacggt ttccgcgcgg aaaaaatcct
0561 cattaagcgc ctgatggata aagtggagaa cggcaacatc attctgcaca ccaaccgtac gctggaagaa
0631 gtgaccggcg atcaaatggg tgtcactggc gttcgtctgc gcgatacgca aaacagcgat aacatcgagt
0701 cactcgacgt tgccggtctg tttgttgcta tcggtcacag cccgaatact gcgattttcg aagggcagct
0771 ggaactggaa aacggctaca tcaaagtaca gtcgggtatt catggtaatg ccacccagac cagcattcct
0841 ggcgtctttg ccgcaggcga cgtgatggat cacatttatc gccaggccat tacttcggcc ggtacaggct
0911 gcatggcagc acttgatgcg gaacgctacc tcgatggttt agctgacgca aaataatttt acaaatcagt
0981 aacaaaagta aagaaggcga caccatgcga ctatgggtcg cctttatttt ttccccgttg taacattgct
1051 ctgcaaataa ttctga
|
