MG1655
W3110
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Gene Report : hcp
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Eur J Biochem. 2000;267(3):666-76.
The hybrid-cluster protein ('prismane protein') from Escherichia coli. Characterization of the hybrid-cluster protein, redox properties of the [2Fe-2S] and [4Fe-2S-2O] clusters and identification of an associated NADH oxidoreductase containing FAD and [2Fe-2S].
van den Berg WA, Hagen WR, van Dongen WM. ( 10651802 )
     Deletion 15 (LD)  ,  15+dps (LD)  ,  OCR48,50-8 (LD 15D::Cm) (D)  ,  OCR49 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  hcp
Related strains
     Strains Search Search strains by gene name:  hcp   Search strains by all related name:  hcp b0873 ECK0864 f552 JW0857 ybjW

General information  (Go to Linear View:)
 Gene Name hcp  
 Alternative name b0873,ECK0864,f552,JW0857,ybjW  
 Location, Length 911,385 - 913,037 (  -  ) ;   19.64 min ; 1653 (bp) ,   550 (aa) Go to Linear View
 Product hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases  
 Operon Name hcp-hcr  
 Note  
 Function orf; Not classified  
 Gene Ontology GO:0003824 ; catalytic activity ( hcp )
GO:0005506 ; iron ion binding ( hcp )
GO:0005515 ; protein binding ( hcp )
GO:0005737 ; cytoplasm ( hcp )
GO:0006118 ; electron transport ( hcp )
GO:0016491 ; oxidoreductase activity ( hcp )
GO:0016661 ; oxidoreductase activity, acting on other nitrogenous compounds as donors ( hcp )
GO:0046872 ; metal ion binding ( hcp )
GO:0050418 ; hydroxylamine reductase activity ( hcp )
GO:0051536 ; iron-sulfur cluster binding ( hcp )
GO:0051537 ; 2 iron, 2 sulfur cluster binding ( hcp )
 PID 87081794  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) HCP_ECOLI ( P75825 ; Q9R7R0; Q9R7R1 )
    -  Protein name Hydroxylamine reductase  
    -  Synonyms EC 1.7.-.-, Hybrid-cluster protein, HCP  
    -  Gene name Name=hcp; OrderedLocusNames=b0873;  

 Linear View (Whole Mode)
View Location
   900.0  –  925.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP hcp (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Hybrid Cluster Protein From Desulfovibrio Desulfuricans X-Ray Structure At 1.25a Resolution Using Synchrotron Radiation At A Wavelength Of 0.933a  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Hydroxylamine reductase  
         PSI-BLAST Hydroxylamine reductase
    nr     (database updated : 2007.02.20 )
         BLAST hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases [Escherichia coli W3110]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A     

Other Cross-Reference
    EcoCyc hcp 

Sequences
Amino acid
FASTA format 
0001 MFCVQCEQTI RTPAGNGCSY AQGMCGKTAE TSDLQDLLIA ALQGLSAWAV KAREYGIINH DVDSFAPRAF 
0071 FSTLTNVNFD SPRIVGYARE AIALREALKA QCLAVDANAR VDNPMADLQL VSDDLGELQR QAAEFTPNKD 
0141 KAAIGENILG LRLLCLYGLK GAAAYMEHAH VLGQYDNDIY AQYHKIMAWL GTWPADMNAL LECSMEIGQM 
0211 NFKVMSILDA GETGKYGHPT PTQVNVKATA GKCILISGHD LKDLYNLLEQ TEGTGVNVYT HGEMLPAHGY 
0281 PELRKFKHLV GNYGSGWQNQ QVEFARFPGP IVMTSNCIID PTVGAYDDRI WTRSIVGWPG VRHLDGDDFS 
0351 AVITQAQQMA GFPYSEIPHL ITVGFGRQTL LGAADTLIDL VSREKLRHIF LLGGCDGARG ERHYFTDFAT 
0421 SVPDDCLILT LACGKYRFNK LEFGDIEGLP RLVDAGQCND AYSAIILAVT LAEKLGCGVN DLPLSLVLSW 
0491 FEQKAIVILL TLLSLGVKNI VTGPTAPGFL TPDLLAVLNE KFGLRSITTV EEDMKQLLSA
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             tcaatctccc ttaaagttgc atgaaaaatc 
-070 ccttttatcc ccgcgttaag cgtcttaacc ttaaacatgt atattaaata taactttaaa aggtgtgatc 
0001 atgttttgtg tgcaatgtga acaaactatc cgtactccgg caggaaacgg ctgctcatac gcgcagggga 
0071 tgtgtggtaa aacggcggaa acttctgacc ttcaggattt actcatcgcg gcgctgcaag ggctttctgc 
0141 ctgggcggta aaagcgcgtg aatacggcat catcaaccac gatgttgaca gcttcgcgcc acgtgccttt 
0211 ttctcaaccc tgaccaacgt taacttcgat tctccgcgta ttgtcggcta cgctcgtgaa gcgattgccc 
0281 tgcgcgaggc gctgaaagcg caatgcctgg ctgtagatgc caacgcgcgc gtcgataacc cgatggctga 
0351 cctgcaactg gtgagcgacg atctcggcga gctgcaacgt caggcagcag aatttacccc taacaaagat 
0421 aaagcggcga ttggcgaaaa cattctcggc ctgcgtctgc tgtgcctgta tggcctgaaa ggtgcggcgg 
0491 cctatatgga acacgcgcat gttctcggtc aatacgacaa cgatatttat gcccagtacc ataaaatcat 
0561 ggcgtggctg gggacctggc ctgccgatat gaacgcgctt cttgagtgtt caatggaaat cggccagatg 
0631 aacttcaaag tgatgagcat tctggatgca ggcgaaaccg gtaaatacgg tcacccgacg ccaacccagg 
0701 tcaacgtcaa agcgacggcg ggtaaatgca ttctgatttc cggtcacgat ctcaaagatc tctacaacct 
0771 gctggaacag accgaaggca cgggcgttaa tgtctacacc cacggcgaaa tgctgcctgc gcatggctac 
0841 ccggagctgc gtaaattcaa gcatctggtc ggtaactacg gcagcggctg gcagaatcag caagtggagt 
0911 tcgctcgttt ccctggcccc atcgtgatga cctcgaactg catcatcgac ccaaccgtag gcgcttatga 
0981 cgatcgtatc tggacccgca gcattgttgg ctggcctggc gtgcgtcatc tggacggtga tgatttctct 
1051 gcggttatca cccaggcgca acagatggca ggcttcccgt acagcgaaat tccgcacctt atcaccgtgg 
1121 gttttggtcg ccagacgctg cttggcgctg ctgatacgct gattgatctg gtgagccgtg aaaaactgcg 
1191 tcatatcttc ctgcttggtg gctgtgacgg cgcacgcggc gagcgccact acttcaccga tttcgccacc 
1261 agcgtgccgg atgactgcct gatcctgacc ctcgcctgtg gtaaatatcg ctttaacaaa cttgagtttg 
1331 gcgatatcga aggtctgccg cgtctggtag atgcaggtca atgtaacgat gcttactcag cgattattct 
1401 ggctgtcact ctggcagaga aactgggctg cggtgtcaac gatctgccgc tgtcgctggt gctctcctgg 
1471 tttgaacaga aagcgatcgt cattctgctg acgctgcttt ctctgggcgt gaaaaatatc gtcaccggcc 
1541 cgactgcacc tggtttcctg acaccagacc tgctggcggt gctgaacgag aaattcggcc tgcgttctat 
1611 caccactgtt gaagaagaca tgaagcaact gttgagcgcg taaggagttt gtcgatgacg atgccaacga 
1681 atcaatgccc gtggcggatg caggttcatc acattacgca agaaacgccg gatgtgtgga cgatttccct 
1751 gat