MG1655
W3110
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Gene Report : ilvH
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCR30 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  ilvH
Related strains
     Strains Search Search strains by gene name:  ilvH   Search strains by all related name:  ilvH b0078 brnP ECK0080 JW0077

General information  (Go to Linear View:)
 Gene Name ilvH  
 Alternative name b0078,brnP,ECK0080,JW0077  
 Location, Length 87,357 - 87,848 (  +  ) ;   1.88 min ; 492 (bp) ,   163 (aa) Go to Linear View
 Product acetolactate synthase III, thiamin-dependent, small subunit  
 Operon Name ilvIH  
 Note acetolactate synthase III, valine sensitive, small subunit  
 Function enzyme; Amino acid biosynthesis: Isoleucine, Valine  
 Gene Ontology GO:0003984 ; acetolactate synthase activity ( ilvH )
GO:0008152 ; metabolic process ( ilvH )
GO:0008652 ; amino acid biosynthetic process ( ilvH )
GO:0009082 ; branched chain family amino acid biosynthetic process ( ilvH )
GO:0016597 ; amino acid binding ( ilvH )
GO:0016740 ; transferase activity ( ilvH )
 PID 1786266  
 EC number
  (KEGG Pathway)
 
2.2.1.6  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) ILVH_ECOLI ( P00894 ; P78046; Q47637 )
    -  Protein name Acetolactate synthase isozyme III small subunit  
    -  Synonyms EC 2.2.1.6, AHAS- III, Acetohydroxy-acid synthase III small subunit, ALS-III  
    -  Gene name Name=ilvH; Synonyms=brnP; OrderedLocusNames=b0078;  

 Linear View (Whole Mode)
View Location
   75.0  –  100.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP ilvH (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of The Regulatory Subunit Of Acetohydroxyacid Synthase Isozyme Iii From E. Coli  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Acetolactate synthase isozyme III small subunit  
         PSI-BLAST Acetolactate synthase isozyme III small subunit
    nr     (database updated : 2007.02.20 )
         BLAST acetolactate synthase small subunit [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    RGD    TONB_DEPENDENT_REC_1     

Other Cross-Reference
    COG COG0440E 
    EcoCyc ilvH 

MMBR References
Genet Res. 1962;3:448-460.
Valine-resistant mutants of Escherichia coli K-12.
Glover, S. W.
J Bacteriol. 1982;149(1):387-90.
Acetohydroxy acid synthase is a target for leucine containing peptide toxicity in Escherichia coli.
Gollop N, Tavori H, Barak Z. ( 7033214 )
FEMS Microbiol Lett. 1995;131(1):95-8.
Control of ilvIH transcription during amino acid downshift in stringent and relaxed strains of Escherichia coli.
Baccigalupi L, Marasco R, Ricca E, De Felice M, Sacco M. ( 7557316 )
Mol Gen Genet. 1991;226(1-2):332-6.
Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2.
Jahreis K, Postma PW, Lengeler JW. ( 1851954 )
J Bacteriol. 1990;172(8):4563-70.
The ilvIH operon of Escherichia coli is positively regulated.
Platko JV, Willins DA, Calvo JM. ( 2115869 )
J Bacteriol. 1965;89:654-60.
REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES.
Ramakrishnan T, Adelberg EA. ( 14273640 )
J Bacteriol. 1981;147(3):797-804.
Physical characterization of the ilvHI operon of Escherichia coli K-12.
Squires CH, De Felice M, Wessler SR, Calvo JM. ( 6168634 )
Nucleic Acids Res. 1983;11:5299-5313
Molecular structure of ilvIH and its evolutionary relationship to ilvG in Escherichia coli K-12.
Squires, C. H., M. DeFelice, J. Devereux, and J. M. Calvo.
J Bacteriol. 1981;148(3):998-1001.
Valine-resistant Escherichia coli K-12 strains with mutations in the ilvB operon.
Sutton A, Newman T, Francis M, Freundlich M. ( 7031038 )
Curr. Top. Microbiol. Immunol. 1969;1:57-76.
Regulation of the biosynthesis of the branched-chain amino acids.
Umbarger, H. E.
Mol Gen Genet. 1977;156(3):239-49.
Valine-sensitive acetohydroxy acid synthases in Escherichia coli K-12: unique regulation modulated by multiple genetic sites.
Davis EJ, Blatt JM, Henderson EK, Whittaker JJ, Jackson JH. ( 340906 )

Sequences
Amino acid
FASTA format
0001 MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT VGDEKVLEQI EKQLHKLVDV 
0071 LRVSELGQGA HVEREIMLVK IQASGYGRDE VKRNTEIFRG QIIDVTPSLY TVQLAGTSGK LDAFLASIRD 
0141 VAKIVEVARS GVVGLSRGDK IMR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TTGATGTTAC CGTCGATGGC AGCGAGCACG 
-070 TCTACCCGAT GCAGATTCGC GGGGGCGGAA TGGATGAAAT GTGGTTAAGC AAAACGGAGA GAACCTGATT 
0001 atgcgccgga tattatcagt cttactcgaa aatgaatcag gcgcgttatc ccgcgtgatt ggcctttttt 
0071 cccagcgtgg ctacaacatt gaaagcctga ccgttgcgcc aaccgacgat ccgacattat cgcgtatgac 
0141 catccagacc gtgggcgatg aaaaagtact tgagcagatc gaaaagcaat tacacaaact ggtcgatgtc 
0211 ttgcgcgtga gtgagttggg gcagggcgcg catgttgagc gggaaatcat gctggtgaaa attcaggcca 
0281 gcggttacgg gcgtgacgaa gtgaaacgta atacggaaat attccgtggg caaattatcg atgtcacacc 
0351 ctcgctttat accgttcaat tagcaggcac cagcggtaag cttgatgcat ttttagcatc gattcgcgat 
0421 gtggcgaaaa ttgtggaggt tgctcgctct ggtgtggtcg gactttcgcg cggcgataaa ataatgcgtt 
0491 gaGAATGATC TCAATGCGCA ATTTACAGCC CAACATGTCA CGTTGGGCTT TTTTTGCGAA ATCAGTGGGA 
0561 ACCTGGAATA AAAGCAGTTG CCGCAGTTAA TT