|
PEC Original Annotations
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|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Proc Natl Acad Sci U S A. 1990;87(1):360-3.
Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K-12.
Lejeune P, Danchin A.
(
2404280
)
|
|
|
Deletion
|
15
(LD)
,
DE(pgl-grxA)502
,
DE(galETK-chlA)
,
15+dps
(LD)
,
OCR48,49-4
(D)
,
OCR48,50-8 (LD 15D::Cm)
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
galE
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
galE
Search strains by all related name:
galE b0759 ECK0748 galD JW0742
|
General information (Go to Linear View: )
|
|
Gene Name
|
galE
|
|
Alternative name
|
b0759,ECK0748,galD,JW0742
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|
Location, Length
|
790,262 - 791,278
(
-
)
;
17.03
min
;
1017
(bp) ,
338
(aa)
|
|
Product
|
UDP-galactose-4-epimerase
|
|
Operon Name
|
galETKM
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_function: GO:0042280 - cell surface antigen activity, host-interacting; GO_process: GO:0006012 - galactose metabolic process; GO_process: GO:0009242 - colanic acid biosynthetic process; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0009435 - NAD biosynthetic process; GO_process: GO:0009269 - response to desiccation
|
|
Function
|
enzyme; Degradation of small molecules: Carbon compounds
|
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Gene Ontology
|
GO:0003824
;
catalytic activity ( galE )
GO:0003978
;
UDP-glucose 4-epimerase activity ( galE )
GO:0005488
;
binding ( galE )
GO:0005975
;
carbohydrate metabolic process ( galE )
GO:0006012
;
galactose metabolic process ( galE )
GO:0008152
;
metabolic process ( galE )
GO:0016853
;
isomerase activity ( galE )
GO:0044237
;
cellular metabolic process ( galE )
GO:0050662
;
coenzyme binding ( galE )
|
|
PID
|
1786974
|
EC number
(KEGG Pathway)
|
5.1.3.2
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
galE
(
EG10362
)
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Number of removed
|
0 aa cleaved
|
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SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
GALE_ECOLI
(
P09147
;
Q47493
)
|
|
- Protein name
|
UDP-glucose 4-epimerase
|
|
- Synonyms
|
EC 5.1.3.2, Galactowaldenase, UDP-galactose 4-epimerase
|
|
- Gene name
|
Name=galE; Synonyms=galD; OrderedLocusNames=b0759;
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Homology Analysis
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|
BLAST
|
|
Bacteria
|
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GTOP
|
galE
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
|
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PSI-BLAST
|
Chain , Udp-Galactose 4-Epimerase From Escherichia Coli
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SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
UDP-glucose 4-epimerase
|
|
PSI-BLAST
|
UDP-glucose 4-epimerase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
UDP-galactose-4-epimerase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
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PROSITE
|
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PROSITE
|
ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
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MMBR References
|
Symp. Soc. Gen. Microbiol. 1960;10:115-131.
Genetic and functional aspects of galactose metabolism in Escherichia coli K-12.
Lederberg, E. M.
|
Nucleic Acids Res. 1986;14:7705-7711
Nucleotide sequences of the galE gene and the galT gene of E. coli.
Lemaire, H. G., and B. Muller-Hill.
|
J Biol Chem. 1981;256:11905-11910
Evidence for two functional gal promoters in intact Escherichia coli cells.
Aiba, H., S. Adhya, and B. de Crombrugghe.
|
J Virol. 1971;8(5):669-74.
Isolation and characterization of an Escherichia coli bacteriophage requiring cell wall galactose.
Watson G, Paigen K.
(
4943683
)
|
Mol Microbiol. 1993;10(2):245-51.
The galactose regulon of Escherichia coli.
Weickert MJ, Adhya S.
(
7934815
)
|
J Mol Biol. 1982;154(2):211-27.
Mutations in the Escherichia coli operon that define two promoters and the binding site of the cyclic AMP receptor protein.
Busby S, Aiba H, de Crombrugghe B.
(
6804633
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MRVLVTGGSG YIGSHTCVQL LQNGHDVIIL DNLCNSKRSV LPVIERLGGK HPTFVEGDIR NEALMTEILH
0071 DHAIDTVIHF AGLKAVGESV QKPLEYYDNN VNGTLRLISA MRAANVKNFI FSSSATVYGD QPKIPYVESF
0141 PTGTPQSPYG KSKLMVEQIL TDLQKAQPDW SIALLRYFNP VGAHPSGDMG EDPQGIPNNL MPYIAQVAVG
0211 RRDSLAIFGN DYPTEDGTGV RDYIHVMDLA DGHVVAMEKL ANKPGVHIYN LGAGVGNSVL DVVNAFSKAC
0281 GKPVNYHFAP RREGDLPAYW ADASKADREL NWRVTRTLDE MAQDTWHWQS RHPQGYPD
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 attcttgtgt aaacgattcc actaatttat
-070 tccatgtcac acttttcgca tctttgttat gctatggtta tttcatacca taagcctaat ggagcgaatt
0001 atgagagttc tggttaccgg tggtagcggt tacattggaa gtcatacctg tgtgcaatta ctgcaaaacg
0071 gtcatgatgt catcattctt gataacctct gtaacagtaa gcgcagcgta ctgcctgtta tcgagcgttt
0141 aggcggcaaa catccaacgt ttgttgaagg cgatattcgt aacgaagcgt tgatgaccga gatcctgcac
0211 gatcacgcta tcgacaccgt gatccacttc gccgggctga aagccgtggg cgaatcggta caaaaaccgc
0281 tggaatatta cgacaacaat gtcaacggca ctctgcgcct gattagcgcc atgcgcgccg ctaacgtcaa
0351 aaactttatt tttagctcct ccgccaccgt ttatggcgat cagcccaaaa ttccatacgt tgaaagcttc
0421 ccgaccggca caccgcaaag cccttacggc aaaagcaagc tgatggtgga acagatcctc accgatctgc
0491 aaaaagccca gccggactgg agcattgccc tgctgcgcta cttcaacccg gttggcgcgc atccgtcggg
0561 cgatatgggc gaagatccgc aaggcattcc gaataacctg atgccataca tcgcccaggt tgctgtaggc
0631 cgtcgcgact cgctggcgat ttttggtaac gattatccga ccgaagatgg tactggcgta cgcgattaca
0701 tccacgtaat ggatctggcg gacggtcacg tcgtggcgat ggaaaaactg gcgaacaagc caggcgtaca
0771 catctacaac ctcggcgctg gcgtaggcaa cagcgtgctg gacgtggtta atgccttcag caaagcctgc
0841 ggcaaaccgg ttaattatca ttttgcaccg cgtcgcgagg gcgaccttcc ggcctactgg gcggacgcca
0911 gcaaagccga ccgtgaactg aactggcgcg taacgcgcac actcgatgaa atggcgcagg acacctggca
0981 ctggcagtca cgccatccac agggatatcc cgattaagga acgaccatga cgcaatttaa tcccgttgat
1051 catccacatc gccgctacaa cccgctcacc gggcaatgga ttctggtttc accgcaccgc gctaagc
|
