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PEC Original Annotations
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Essentiality
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Class
|
non-essential
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|
References (PMID)
|
|
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Deletion
|
DE(pgl-grxA)502
,
OCR48,49-15
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
nadA
|
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Related strains
|
|
Strains Search
|
Search strains by gene name:
nadA
Search strains by all related name:
nadA b0750 ECK0739 JW0733 nicA o347
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General information (Go to Linear View: )
|
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Gene Name
|
nadA
|
|
Alternative name
|
b0750,ECK0739,JW0733,nicA,o347
|
|
Location, Length
|
781,308 - 782,351
(
+
)
;
16.84
min
;
1044
(bp) ,
347
(aa)
|
|
Product
|
quinolinate synthase, subunit A
|
|
Operon Name
|
nadA-pnuC
|
|
Note
|
quinolinate synthetase, A protein; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009435 - NAD biosynthetic process
|
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Function
|
enzyme; Biosynthesis of cofactors, carriers: Pyridine nucleotide
|
|
Gene Ontology
|
GO:0005737
;
cytoplasm ( nadA )
GO:0008987
;
quinolinate synthetase A activity ( nadA )
GO:0009435
;
NAD biosynthetic process ( nadA )
GO:0019363
;
pyridine nucleotide biosynthetic process ( nadA )
|
|
PID
|
1786964
|
EC number
(KEGG Pathway)
|
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
NADA_ECOLI
(
P11458
;
P77373
)
|
|
- Protein name
|
Quinolinate synthetase A.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=nadA; Synonyms=nicA; OrderedLocusNames=b0750;
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Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
nadA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Quinolinate Synthase
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Quinolinate synthetase A
|
|
PSI-BLAST
|
Quinolinate synthetase A
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
quinolinate synthetase [Escherichia coli K12]
|
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
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|
MMBR References
|
Eur J Biochem. 1988;175:221-228
Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB.
Flachmann, R., N. Kunz, J. Seifert, M. Gutlich, F. J. Wientjes, A. Laufer, and H. G. Gassen.
|
J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J.
(
4397929
)
|
J. Microbiol. Serol. 1969;35:505-521
A genetical and biochemical study of chlorate-resistant mutants of Salmonella typhimurium. Antonie Leeuwenhoek.
Stouthamer, A. H.
|
| Sequences |
Amino acid
FASTA format
|
0001 MSVMFDPDTA IYPFPPKPTP LSIDEKAYYR EKIKRLLKER NAVMVAHYYT DPEIQQLAEE TGGCISDSLE
0071 MARFGAKHPA STLLVAGVRF MGETAKILSP EKTILMPTLQ AECSLDLGCP VEEFNAFCDA HPDRTVVVYA
0141 NTSAAVKARA DWVVTSSIAV ELIDHLDSLG EKIIWAPDKH LGRYVQKQTG GDILCWQGAC IVHDEFKTQA
0211 LTRLQEEYPD AAILVHPESP QAIVDMADAV GSTSQLIAAA KTLPHQRLIV ATDRGIFYKM QQAVPDKELL
0281 EAPTAGEGAT CRSCAHCPWM AMNGLQAIAE ALEQEGSNHE VHVDERLRER ALVPLNRMLD FAATLRG
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TCGACTATCT TGTTTAGCAT ATAAAACAAA
-070 TTACACCGAT AACAGCGAAT ATTACGCTAA TGTCGGTTTT AACGTTAAGC CTGTAAAACG AGATGGTAAG
0001 atgagcgtaa tgtttgatcc agacacggcg atttatcctt tccccccgaa gccgacgccg ttaagcattg
0071 atgaaaaagc gtattaccgc gagaagataa aacgtctgct aaaagaacgt aatgcggtga tggttgccca
0141 ctactatacc gatcccgaaa ttcaacaact ggcagaagaa accggtggct gtatttctga ttctctggaa
0211 atggcgcgct tcggtgcaaa gcatcccgct tctactttgt tagtcgctgg ggtgagattt atgggagaaa
0281 ccgccaaaat tctcagtccg gaaaaaacaa ttctgatgcc gacacttcag gctgaatgtt cactggatct
0351 cggctgccct gttgaagaat ttaacgcatt ttgcgatgcc catcccgatc gtactgtcgt cgtctacgcc
0421 aacacttctg ctgcggtaaa agcgcgcgca gattgggtgg taacttcaag cattgccgtc gaacttattg
0491 atcatcttga tagtttgggt gaaaaaatca tctgggcacc cgacaaacat ctggggcgtt acgtgcaaaa
0561 acagacgggt ggagacattc tatgctggca gggtgcctgt attgtgcatg atgaatttaa gactcaggcg
0631 ttaacccgct tgcaagaaga atacccggat gctgccatac tggtgcatcc agaatcacca caagctattg
0701 tcgatatggc ggatgcggtc ggttccacca gtcaactgat cgctgctgcg aaaacattgc cacatcagag
0771 gcttattgtg gcaaccgatc ggggtatttt ctacaaaatg cagcaggcgg tgccagataa agagttactg
0841 gaagcaccaa ccgcaggtga gggtgcaacc tgccgcagct gcgcgcattg tccgtggatg gccatgaatg
0911 gccttcaggc catcgcagag gcattagaac aggaaggaag caatcacgag gttcatgttg atgaaaggct
0981 gcgagagagg gcgctggtgc cgctcaatcg tatgctggat tttgcggcta cactacgtgg ataaCGAATA
1051 ATAAGGCGTA ACGTTACGCT TTGGGGGAAA GATGGATTTT TTTAGTGTGC AGAATATCCT GGTACATATA
1121 CCAATAGGGG CAGGCGGTTA TGAT
|
