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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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DE(pgl-grxA)502
,
OCR48,49-8
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
kdpD
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Related strains
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Strains Search
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Search strains by gene name:
kdpD
Search strains by all related name:
kdpD b0695 ECK0683 JW0683 kac
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General information (Go to Linear View: )
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Gene Name
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kdpD
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Alternative name
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b0695,ECK0683,JW0683,kac
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Location, Length
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720,953 - 723,637
(
-
)
;
15.54
min
;
2685
(bp) ,
894
(aa)
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Product
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fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein
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Operon Name
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kdpDE
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Note
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sensor for high-affinity potassium transport system; sensory histidine kinase; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006464 - protein modification process
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Function
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enzyme; Global regulatory functions
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Gene Ontology
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GO:0000155
;
two-component sensor activity ( kdpD )
GO:0000160
;
two-component signal transduction system (phosphorelay) ( kdpD )
GO:0004673
;
protein histidine kinase activity ( kdpD )
GO:0004871
;
signal transducer activity ( kdpD )
GO:0005524
;
ATP binding ( kdpD )
GO:0005886
;
plasma membrane ( kdpD )
GO:0006950
;
response to stress ( kdpD )
GO:0007165
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signal transduction ( kdpD )
GO:0016020
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membrane ( kdpD )
GO:0016021
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integral to membrane ( kdpD )
GO:0016301
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kinase activity ( kdpD )
GO:0016310
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phosphorylation ( kdpD )
GO:0016740
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transferase activity ( kdpD )
GO:0016772
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transferase activity, transferring phosphorus-containing groups ( kdpD )
GO:0018106
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peptidyl-histidine phosphorylation ( kdpD )
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PID
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1786912
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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KDPD_ECOLI
(
P21865
)
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- Protein name
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Sensor protein kdpD
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- Synonyms
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EC 2.7.3.-
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- Gene name
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Name=kdpD; OrderedLocusNames=b0695;
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MMBR References
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J Bacteriol. 1993;175:4528-4537
Regulation of kdp operon expression in Escherichia coli: evidence against turgor as signal for transcriptional control.
Asha, H., and J. Gowrishankar.
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Mol Microbiol. 1993;7(1):109-16.
Signal transduction between the two regulatory components involved in the regulation of the kdpABC operon in Escherichia coli: phosphorylation-dependent functioning of the positive regulator, KdpE.
Nakashima K, Sugiura A, Kanamaru K, Mizuno T.
(
8437514
)
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J. Biochem. (Tokyo) 1993;114:615-621
Functional reconstitution of the putative Escherichia coli osmosensor, KdpD, into liposomes.
Nakashima, K., A. Sugiura, and T. Mizuno.
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J Bacteriol. 1992;174:2145-2151
The products of the kdpDE operon are required for expression of the Kdp ATPase of Escherichia coli.
Polarek, J. W., G. Williams, and W. Epstein.
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J Biol Chem. 1996;271:25027-25034
Characterization of truncated forms of the KdpD protein, the sensor kinase of the K+-translocating Kdp system of Escherichia coli.
Puppe, W., P. Zimmann, K. Jung, M. Lucassen, and K. Altendorf.
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Mol Microbiol. 1992;6(13):1769-76.
Clarification of the structural and functional features of the osmoregulated kdp operon of Escherichia coli.
Sugiura A, Nakashima K, Tanaka K, Mizuno T.
(
1630316
)
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Eur J Biochem. 1993;217:1019-1026
Characterization of the KdpD protein, the sensor kinase of the K+-translocating Kdp system of Escherichia coli.
Voelkner, P., W. Puppe, and K. Altendorf.
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J Bacteriol. 1992;174:2152-2159
KdpD and KdpE, proteins that control expression of the kdpABC operon, are members of the two-component sensor-effector class of regulators.
Walderhaug, M. O., J. W. Polarek, P. Voelkner, J. Daniel, J. E. Hesse, K. Altendorf, and W. Epstein.
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| Sequences |
Amino acid
FASTA format
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0001 MNNEPLRPDP DRLLEQTAAP HRGKLKVFFG ACAGVGKTWA MLAEAQRLRA QGLDIVVGVV ETHGRKDTAA
0071 MLEGLAVLPL KRQAYRGRHI SEFDLDAALA RRPALILMDE LAHSNAPGSR HPKRWQDIEE LLEAGIDVFT
0141 TVNVQHLESL NDVVSGVTGI QVRETVPDPF FDAADDVVLV DLPPDDLRQR LKEGKVYIAG QAERAIEHFF
0211 RKGNLIALRE LALRRTADRV DEQMRAWRGH PGEEKVWHTR DAILLCIGHN TGSEKLVRAA ARLASRLGSV
0281 WHAVYVETPA LHRLPEKKRR AILSALRLAQ ELGAETATLS DPAEEKAVVR YAREHNLGKI ILGRPASRRW
0351 WRRETFADRL ARIAPDLDQV LVALDEPPAR TINNAPDNRS FKDKWRVQIQ GCVVAAALCA VITLIAMQWL
0421 MAFDAANLVM LYLLGVVVVA LFYGRWPSVV ATVINVVSFD LFFIAPRGTL AVSDVQYLLT FAVMLTVGLV
0491 IGNLTAGVRY QARVARYREQ RTRHLYEMSK ALAVGRSPQD IAATSEQFIA STFHARSQVL LPDDNGKLQP
0561 LTHPQGMTPW DDAIAQWSFD KGLPAGAGTD TLPGVPYQIL PLKSGEKTYG LVVVEPGNLR QLMIPEQQRL
0631 LETFTLLVAN ALERLTLTAS EEQARMASER EQIRNALLAA LSHDLRTPLT VLFGQAEILT LDLASEGSPH
0701 ARQASEIRQH VLNTTRLVNN LLDMARIQSG GFNLKKEWLT LEEVVGSALQ MLEPGLSSPI NLSLPEPLTL
0771 IHVDGPLFER VLINLLENAV KYAGAQAEIG IDAHVEGENL QLDVWDNGPG LPPGQEQTIF DKFARGNKES
0841 AVPGVGLGLA ICRAIVDVHG GTITAFNRPE GGACFRVTLP QQTAPELEEF HEDM
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 acgcaactga tcgcaaaata cagccaacaa
-070 ccgctggtga aatatatcgg ccagccggtt gtcaacattg ttgaactcaa tctggcgctg gataaacttg
0001 atgaataacg aacccttacg tcccgacccc gatcgtctgc tggaacaaac tgccgcgccg catcggggga
0071 agctgaaagt tttcttcggt gcctgtgcag gcgtcgggaa gacctgggcg atgctggcag aagcccagcg
0141 actgcgggcg caagggctgg atattgtggt tggcgtggta gaaacccacg ggcgaaaaga taccgccgcc
0211 atgctggaag ggctggctgt tctgccgtta aaacgccagg cgtaccgtgg gcggcatatc agcgagtttg
0281 atctcgatgc cgccctcgcc cgccgcccgg cgctgatctt aatggacgaa ctggcgcaca gtaatgcgcc
0351 aggttcccgt catcccaaac gctggcagga tatcgaagaa ctgctggaag ctggcattga tgttttcact
0421 accgtcaacg ttcagcatct ggaaagtctg aatgatgtgg tcagcggcgt caccggaatt caggtacggg
0491 aaaccgtgcc cgatcctttt ttcgatgccg ccgacgacgt ggtgctggtg gacttgcccc cggacgatct
0561 gcgccagcgg ctgaaagaag gcaaagtcta tattgccggg caggcggagc gcgccattga acattttttc
0631 cgcaaaggta atctgatcgc cctgcgcgaa ctggcactgc gccgtactgc cgatcgcgtt gatgagcaaa
0701 tgcgcgcctg gcgggggcat cctggcgaag agaaagtgtg gcacacgcgc gacgcgatcc ttttatgcat
0771 cggccataac accggcagcg aaaaactggt ccgcgcagcg gcgcggctgg cgtcacggct gggtagcgtc
0841 tggcacgcgg tgtatgttga aacccctgcc ctgcaccgct taccggaaaa aaaacgtcgg gcaattctca
0911 gcgccttacg tctggcgcag gaactgggcg cggagacggc aacactttct gatccagcgg aagagaaagc
0981 ggtagtgcgt tatgcccgtg aacataatct cggcaagatt attctcggtc gcccggcctc gcgccgctgg
1051 tggcgtcggg aaacgtttgc tgaccgactg gcgcgcatcg cccccgatct cgatcaggtg ctggtcgcgc
1121 ttgatgaacc acccgcccgc acgattaaca acgcgccgga taaccgctct tttaaagaca agtggcgtgt
1191 acaaattcag ggatgcgtgg ttgccgccgc gttatgcgcc gttatcacct taattgccat gcagtggctg
1261 atggcgtttg atgccgccaa cctggtgatg ctgtatctgc ttggcgtggt ggtggtggcg ctattttatg
1331 gacgctggcc ttcagtggtt gccaccgtca ttaatgtagt gagtttcgat ctctttttta tcgccccacg
1401 cggcacgctc gccgtctctg atgtgcaata tctgctgacc ttcgcggtga tgttaaccgt cgggctggtg
1471 atcgggaacc ttactgctgg cgtgcgttat caggcgcggg tagcccgtta ccgcgagcaa cgcacacggc
1541 acttatatga aatgtcgaaa gctctggcgg tgggccgcag tccgcaggat atcgctgcca ccagcgaaca
1611 atttattgcc tccacgtttc atgcccgcag tcaggtgttg ttgcccgatg acaacggtaa attgcagccg
1681 ttaacacatc cgcaaggaat gacgccgtgg gacgatgcca tcgcgcagtg gagttttgat aaaggcctgc
1751 ctgcgggcgc gggcaccgac acgttacccg gtgtaccgta ccagattttg ccgctaaaaa gcggcgagaa
1821 aacctacggg ctggtggtgg tggagccggg gaatctgcgc cagttgatga tcccggaaca gcagcgcctg
1891 ctggagacgt ttacgctgtt agtcgccaat gcccttgagc ggctgacgct aaccgccagc gaagaacagg
1961 cgcggatggc aagcgaacgt gaacagatcc gcaacgccct gctggcggcg ctttcgcatg atttacgcac
2031 gccgcttacg gtgctgtttg gtcaggcaga aatcttaacg ctcgatctgg caagcgaagg atcaccccac
2101 gcccgccagg ccagcgagat ccgtcagcat gtgctgaaca ctacccgact ggtgaataat ctactggata
2171 tggcgcgaat tcagtccggc ggctttaatt tgaagaaaga gtggttaacg ctggaagaag tagtcggcag
2241 cgcgctgcaa atgctggaac cgggtttatc gtcgcccatc aatctttctc tgccagaacc gctgacctta
2311 atccacgttg acgggccact ctttgaacgg gtgctgatta atctgctgga gaacgcggtg aaatatgcgg
2381 gtgcgcaggc cgaaattggt atcgatgccc acgttgaggg cgaaaatcta caactggatg tctgggataa
2451 cggccccggt cttccgccag gccaggagca gacgatattt gataagtttg ctcgcgggaa taaagagtcg
2521 gcagtaccgg gggtagggct tggactggca atttgtcggg cgatagtgga tgtacacggg ggcactatta
2591 ccgcgttcaa ccgaccggaa ggtggtgcct gttttcgtgt tacacttccc cagcaaactg cccctgaact
2661 tgaagaattt catgaggata tgtgacaaac gttctgattg ttgaagatga acaggctatt cgtcgctttc
2731 tgcgcacggc gctggagggc gacgggatgc gcgtctttga ggccgaaacg ctgca
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