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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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DE(araA-leu)7697
,
OCR29
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
araC
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Related strains
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Strains Search
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Search strains by gene name:
araC
Search strains by all related name:
araC b0064 ECK0065 JW0063
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General information (Go to Linear View: )
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Gene Name
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araC
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Alternative name
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b0064,ECK0065,JW0063
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Location, Length
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70,387 - 71,265
(
+
)
;
1.52
min
;
879
(bp) ,
292
(aa)
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Product
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DNA-binding transcriptional dual regulator
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Operon Name
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araC
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Note
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transcriptional regulator for ara operon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0006350 - transcription
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Function
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regulator; Degradation of small molecules: Carbon compounds
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Gene Ontology
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GO:0003677
;
DNA binding ( araC )
GO:0003700
;
transcription factor activity ( araC )
GO:0005622
;
intracellular ( araC )
GO:0005737
;
cytoplasm ( araC )
GO:0005975
;
carbohydrate metabolic process ( araC )
GO:0006350
;
transcription ( araC )
GO:0006355
;
regulation of transcription, DNA-dependent ( araC )
GO:0019568
;
arabinose catabolic process ( araC )
GO:0043565
;
sequence-specific DNA binding ( araC )
GO:0045449
;
regulation of transcription ( araC )
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PID
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1786251
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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araC
(
EG10054
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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ARAC_ECOLI
(
P03021
;
Q47056
)
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- Protein name
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Arabinose operon regulatory protein.
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- Synonyms
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- Gene name
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Name=araC; OrderedLocusNames=b0064, z0073, ECs0068;
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MMBR References
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J Mol Biol. 1984;180(1):201-4.
Deletion analysis of the Escherichia coli ara PC and PBAD promoters.
Dunn TM, Schleif R.
(
6392566
)
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J Bacteriol. 1965;90(4):946-57.
Positive control of enzyme synthesis by gene C in the L-arabinose system.
Englesberg E, Irr J, Power J, Lee N.
(
5321403
)
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J Bacteriol. 1970;102(2):593-5.
Selection of araB and araC mutants of Escherichia coli B-r by resistance to ribitol.
Katz L.
(
4911550
)
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J Mol Biol. 1981;151(2):215-27.
Regulation of the L-arabinose transport operons in Escherichia coli.
Kolodrubetz D, Schleif R.
(
6461771
)
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Proc Natl Acad Sci U S A. 1981;78:752-756
Mechanism of araC autoregulation and the domains of two overlapping promoters, Pc and Pbad, in the L-arabinose regulatory region of Escherichia coli.
Lee, N., W. Gielow, and R. G. Wallace.
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Nucleic Acids Res. 1980;8:5267-5274
DNA sequence of the araC regulatory gene from Escherichia coli B/r.
Miyada, C. G., A. H. Horwitz, L. G. Cass, J. Timko, and G. Wilcox.
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Proc Natl Acad Sci U S A. 1980;77:3346-3350
The Escherichia coli L-arabinose operon: binding sites of the regulatory proteins and a mechanism of positive and negative regulation.
Ogden, S., D. Haggerty, C. M. Stoner, D. Kolodrubetz, and R. Schleif.
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J Bacteriol. 1986;168(2):999-1001.
Dominance relationships among mutant alleles of regulatory gene araC in the Escherichia coli B/R L-arabinose operon.
Sheppard DE.
(
3023295
)
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J Biol Chem. 1978;253:6931-6933
Nucleotide sequence of the L-arabinose regulatory region of Escherichia coli K12.
Smith, B. R., and R. Schleif.
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J Mol Biol. 1982;154(4):649-52.
Is the amino acid but not the nucleotide sequence of the Escherichia coli araC gene conserved?
Stoner CM, Schleif R.
(
6283093
)
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Gene. 1980;12(3-4):179-90.
The araC gene of Escherichia coli: transcriptional and translational start-points and complete nucleotide sequence.
Wallace RG, Lee N, Fowler AV.
(
7019009
)
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EMBO J. 1993;12:35-44
Variation of half-site organization and DNA looping by AraC protein.
Carra, J. H., and R. F. Schleif.
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Mol Gen Genet. 1980;180(1):219-26.
The araC regulatory gene mRNA contains a leader sequence.
Cass LG, Horwitz AH, Miyada CG, Greenfield L, Wilcox G.
(
6160371
)
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| Sequences |
Amino acid
FASTA format
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0001 MAEAQNDPLL PGYSFNAHLV AGLTPIEANG YLDFFIDRPL GMKGYILNLT IRGQGVVKNQ GREFVCRPGD
0071 ILLFPPGEIH HYGRHPEARE WYHQWVYFRP RAYWHEWLNW PSIFANTGFF RPDEAHQPHF SDLFGQIINA
0141 GQGEGRYSEL LAINLLEQLL LRRMEAINES LHPPMDNRVR EACQYISDHL ADSNFDIASV AQHVCLSPSR
0211 LSHLFRQQLG ISVLSWREDQ RISQAKLLLS TTRMPIATVG RNVGFDDQLY FSRVFKKCTG ASPSEFRAGC
0281 EEKVNDVAVK LS
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 TTGGGTTAGC GAGAAGAGCC AGTAAAAGAC
-070 GCAGTGACGG CAATGTCTGA TGCAATATGG ACAATTGGTT TCTTCTCTGA ATGGTGGGAG TATGAAAAGT
0001 atggctgaag cgcaaaatga tcccctgctg ccgggatact cgtttaacgc ccatctggtg gcgggtttaa
0071 cgccgattga ggccaacggt tatctcgatt tttttatcga ccgaccgctg ggaatgaaag gttatattct
0141 caatctcacc attcgcggtc agggggtggt gaaaaatcag ggacgagaat ttgtctgccg accgggtgat
0211 attttgctgt tcccgccagg agagattcat cactacggtc gtcatccgga ggctcgcgaa tggtatcacc
0281 agtgggttta ctttcgtccg cgcgcctact ggcatgaatg gcttaactgg ccgtcaatat ttgccaatac
0351 gggtttcttt cgcccggatg aagcgcacca gccgcatttc agcgacctgt ttgggcaaat cattaacgcc
0421 gggcaagggg aagggcgcta ttcggagctg ctggcgataa atctgcttga gcaattgtta ctgcggcgca
0491 tggaagcgat taacgagtcg ctccatccac cgatggataa tcgggtacgc gaggcttgtc agtacatcag
0561 cgatcacctg gcagacagca attttgatat cgccagcgtc gcacagcatg tttgcttgtc gccgtcgcgt
0631 ctgtcacatc ttttccgcca gcagttaggg attagcgtct taagctggcg cgaggaccaa cgcattagtc
0701 aggcgaagct gcttttgagc actacccgga tgcctatcgc caccgtcggt cgcaatgttg gttttgacga
0771 tcaactctat ttctcgcgag tatttaaaaa atgcaccggg gccagcccga gcgagtttcg tgccggttgt
0841 gaagaaaaag tgaatgatgt agccgtcaag ttgtcataaT TGGTAACGAA TCAGACAATT GACGGCTTGA
0911 CGGAGTAGCA TAGGGTTTGC AGAATCCCTG CTTCGTCCAT TTGACAGGCA CATTATGCAA GCATTGCTG
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