MG1655
W3110
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Gene Report : araC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion DE(araA-leu)7697  ,  OCR29 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  araC
Related strains
     Strains Search Search strains by gene name:  araC   Search strains by all related name:  araC b0064 ECK0065 JW0063

General information  (Go to Linear View:)
 Gene Name araC  
 Alternative name b0064,ECK0065,JW0063  
 Location, Length 70,387 - 71,265 (  +  ) ;   1.52 min ; 879 (bp) ,   292 (aa) Go to Linear View
 Product DNA-binding transcriptional dual regulator  
 Operon Name araC  
 Note transcriptional regulator for ara operon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0006350 - transcription  
 Function regulator; Degradation of small molecules: Carbon compounds  
 Gene Ontology GO:0003677; DNA binding ( araC )
GO:0003700; transcription factor activity ( araC )
GO:0005622; intracellular ( araC )
GO:0005737; cytoplasm ( araC )
GO:0005975; carbohydrate metabolic process ( araC )
GO:0006350; transcription ( araC )
GO:0006355; regulation of transcription, DNA-dependent ( araC )
GO:0019568; arabinose catabolic process ( araC )
GO:0043565; sequence-specific DNA binding ( araC )
GO:0045449; regulation of transcription ( araC )
 PID 1786251  
 EC number
  (KEGG Pathway)
 
 
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene araC ( EG10054 )  
    Number of removed 1 aa cleaved  
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) ARAC_ECOLI ( P03021 ; Q47056 )
    -  Protein name Arabinose operon regulatory protein.  
    -  Synonyms  
    -  Gene name Name=araC; OrderedLocusNames=b0064, z0073, ECs0068;  

 Linear View (Whole Mode)
View Location
   60.0  –  85.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP araC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Apo Form Of The Y31v Mutant Dimerization Domain Fragment Of Escherichia Coli Regulatory Protein Arac  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Arabinose operon regulatory protein  
         PSI-BLAST Arabinose operon regulatory protein
    nr     (database updated : 2007.02.20 )
         BLAST transcriptional regulator AraC [Broad host range vector pMLBAD]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    HTH_ARAC_FAMILY_1     

Other Cross-Reference
    EcoCyc araC 

MMBR References
J Mol Biol. 1984;180(1):201-4.
Deletion analysis of the Escherichia coli ara PC and PBAD promoters.
Dunn TM, Schleif R. ( 6392566 )
J Bacteriol. 1965;90(4):946-57.
Positive control of enzyme synthesis by gene C in the L-arabinose system.
Englesberg E, Irr J, Power J, Lee N. ( 5321403 )
J Bacteriol. 1970;102(2):593-5.
Selection of araB and araC mutants of Escherichia coli B-r by resistance to ribitol.
Katz L. ( 4911550 )
J Mol Biol. 1981;151(2):215-27.
Regulation of the L-arabinose transport operons in Escherichia coli.
Kolodrubetz D, Schleif R. ( 6461771 )
Proc Natl Acad Sci U S A. 1981;78:752-756
Mechanism of araC autoregulation and the domains of two overlapping promoters, Pc and Pbad, in the L-arabinose regulatory region of Escherichia coli.
Lee, N., W. Gielow, and R. G. Wallace.
Nucleic Acids Res. 1980;8:5267-5274
DNA sequence of the araC regulatory gene from Escherichia coli B/r.
Miyada, C. G., A. H. Horwitz, L. G. Cass, J. Timko, and G. Wilcox.
Proc Natl Acad Sci U S A. 1980;77:3346-3350
The Escherichia coli L-arabinose operon: binding sites of the regulatory proteins and a mechanism of positive and negative regulation.
Ogden, S., D. Haggerty, C. M. Stoner, D. Kolodrubetz, and R. Schleif.
J Bacteriol. 1986;168(2):999-1001.
Dominance relationships among mutant alleles of regulatory gene araC in the Escherichia coli B/R L-arabinose operon.
Sheppard DE. ( 3023295 )
J Biol Chem. 1978;253:6931-6933
Nucleotide sequence of the L-arabinose regulatory region of Escherichia coli K12.
Smith, B. R., and R. Schleif.
J Mol Biol. 1982;154(4):649-52.
Is the amino acid but not the nucleotide sequence of the Escherichia coli araC gene conserved?
Stoner CM, Schleif R. ( 6283093 )
Gene. 1980;12(3-4):179-90.
The araC gene of Escherichia coli: transcriptional and translational start-points and complete nucleotide sequence.
Wallace RG, Lee N, Fowler AV. ( 7019009 )
EMBO J. 1993;12:35-44
Variation of half-site organization and DNA looping by AraC protein.
Carra, J. H., and R. F. Schleif.
Mol Gen Genet. 1980;180(1):219-26.
The araC regulatory gene mRNA contains a leader sequence.
Cass LG, Horwitz AH, Miyada CG, Greenfield L, Wilcox G. ( 6160371 )

Sequences
Amino acid
FASTA format
0001 MAEAQNDPLL PGYSFNAHLV AGLTPIEANG YLDFFIDRPL GMKGYILNLT IRGQGVVKNQ GREFVCRPGD 
0071 ILLFPPGEIH HYGRHPEARE WYHQWVYFRP RAYWHEWLNW PSIFANTGFF RPDEAHQPHF SDLFGQIINA 
0141 GQGEGRYSEL LAINLLEQLL LRRMEAINES LHPPMDNRVR EACQYISDHL ADSNFDIASV AQHVCLSPSR 
0211 LSHLFRQQLG ISVLSWREDQ RISQAKLLLS TTRMPIATVG RNVGFDDQLY FSRVFKKCTG ASPSEFRAGC 
0281 EEKVNDVAVK LS

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TTGGGTTAGC GAGAAGAGCC AGTAAAAGAC 
-070 GCAGTGACGG CAATGTCTGA TGCAATATGG ACAATTGGTT TCTTCTCTGA ATGGTGGGAG TATGAAAAGT 
0001 atggctgaag cgcaaaatga tcccctgctg ccgggatact cgtttaacgc ccatctggtg gcgggtttaa 
0071 cgccgattga ggccaacggt tatctcgatt tttttatcga ccgaccgctg ggaatgaaag gttatattct 
0141 caatctcacc attcgcggtc agggggtggt gaaaaatcag ggacgagaat ttgtctgccg accgggtgat 
0211 attttgctgt tcccgccagg agagattcat cactacggtc gtcatccgga ggctcgcgaa tggtatcacc 
0281 agtgggttta ctttcgtccg cgcgcctact ggcatgaatg gcttaactgg ccgtcaatat ttgccaatac 
0351 gggtttcttt cgcccggatg aagcgcacca gccgcatttc agcgacctgt ttgggcaaat cattaacgcc 
0421 gggcaagggg aagggcgcta ttcggagctg ctggcgataa atctgcttga gcaattgtta ctgcggcgca 
0491 tggaagcgat taacgagtcg ctccatccac cgatggataa tcgggtacgc gaggcttgtc agtacatcag 
0561 cgatcacctg gcagacagca attttgatat cgccagcgtc gcacagcatg tttgcttgtc gccgtcgcgt 
0631 ctgtcacatc ttttccgcca gcagttaggg attagcgtct taagctggcg cgaggaccaa cgcattagtc 
0701 aggcgaagct gcttttgagc actacccgga tgcctatcgc caccgtcggt cgcaatgttg gttttgacga 
0771 tcaactctat ttctcgcgag tatttaaaaa atgcaccggg gccagcccga gcgagtttcg tgccggttgt 
0841 gaagaaaaag tgaatgatgt agccgtcaag ttgtcataaT TGGTAACGAA TCAGACAATT GACGGCTTGA 
0911 CGGAGTAGCA TAGGGTTTGC AGAATCCCTG CTTCGTCCAT TTGACAGGCA CATTATGCAA GCATTGCTG