|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR43
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
purE
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
purE
Search strains by all related name:
purE ade ade3 b0523 ECK0516 JW0512 Pur2
|
General information (Go to Linear View: )
|
|
Gene Name
|
purE
|
|
Alternative name
|
ade,ade3,b0523,ECK0516,JW0512,Pur2
|
|
Location, Length
|
551,814 - 552,323
(
-
)
;
11.89
min
;
510
(bp) ,
169
(aa)
|
|
Product
|
N5-carboxyaminoimidazole ribonucleotide mutase
|
|
Operon Name
|
purEK
|
|
Note
|
phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006164 - purine nucleotide biosynthetic process
|
|
Function
|
enzyme; Purine ribonucleotide biosynthesis
|
|
Gene Ontology
|
GO:0000034
;
adenine deaminase activity ( ade )
GO:0004638
;
phosphoribosylaminoimidazole carboxylase activity ( purE )
GO:0006146
;
adenine catabolic process ( ade )
GO:0006164
;
purine nucleotide biosynthetic process ( purE )
GO:0006189
;
'de novo' IMP biosynthetic process ( purE )
GO:0009320
;
phosphoribosylaminoimidazole carboxylase complex ( purE )
GO:0016787
;
hydrolase activity ( ade )
GO:0016810
;
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ( ade )
GO:0016829
;
lyase activity ( purE )
GO:0016831
;
carboxy-lyase activity ( purE )
GO:0030145
;
manganese ion binding ( ade )
|
|
PID
|
1786734
|
EC number
(KEGG Pathway)
|
4.1.1.21
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
purE
(
EG10793
)
|
|
Number of removed
|
1 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
PUR6_ECOLI
(
P09028
)
|
|
- Protein name
|
Phosphoribosylaminoimidazole carboxylase catalytic subunit
|
|
- Synonyms
|
EC 4.1.1.21, AIR carboxylase, AIRC
|
|
- Gene name
|
Name=purE; OrderedLocusNames=b0523, z0678, ECs0585;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
purE
(
homologous genes of other bacterias
)
ade
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Pure (Ba0288) From Bacillus Anthracis At 1.8 Resolution
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIR carboxylase) (AIRC)
|
|
PSI-BLAST
|
Phosphoribosylaminoimidazole carboxylase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
phosphoribosylaminoimidazole carboxylase catalytic subunit [Escherichia coli O157:H7 EDL933]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
|
|
MMBR References
|
Gene. 1983;22(2-3):281-7.
A partial restriction map of the proA-purE region of the Escherichia coli K12 chromosome.
Hadley RG, Hu M, Timmons M, Yun K, Deonier RC.
(
6307829
)
|
Gene. 1986;44(1):55-62.
Molecular cloning and characterization of the purE operon of Escherichia coli.
Kamholz J, Keyhani J, Gots JS.
(
3021590
)
|
J Bacteriol. 1989;171(1):205-12.
Nucleotide sequence analysis of the purEK operon encoding 5'-phosphoribosyl-5-aminoimidazole carboxylase of Escherichia coli K-12.
Tiedeman AA, Keyhani J, Kamholz J, Daum HA 3rd, Gots JS, Smith JM.
(
2464576
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSSRNNPARV AIVMGSKSDW ATMQFAAEIF EILNVPHHVE VVSAHRTPDK LFSFAESAEE NGYQVIIAGA
0071 GGAAHLPGMI AAKTLVPVLG VPVQSAALSG VDSLYSIVQM PRGIPVGTLA IGKAGAANAA LLAAQILATH
0141 DKELHQRLND WRKAQTDEVL ENPDPRGAA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tgatttcaca gccacgcaac cgttttcctt
-070 gctctctttc cgtgctattc tctgtgccct ctaaagccga gagttgtgca ccacaggagt tttaagacgc
0001 atgtcttccc gcaataatcc ggcgcgtgtc gccatcgtga tggggtccaa aagcgactgg gctaccatgc
0071 agttcgccgc cgaaatcttc gaaatcctga atgtcccgca ccacgttgaa gtggtttctg ctcaccgcac
0141 ccccgataaa ctgttcagct tcgccgaaag cgccgaagag aacggttatc aggtgattat tgcgggcgca
0211 ggcggcgcag cgcatctgcc aggcatgatt gccgccaaaa cgctggtgcc ggtgctgggc gtgccagtac
0281 agagcgccgc actgagcggt gtcgatagcc tctactccat cgtacaaatg ccgcgcggca ttccggtggg
0351 tacgctggcg attggtaaag ctggcgcggc aaacgcggcg ttactggcag cacaaattct tgcgactcat
0421 gataaagaac tgcaccagcg tctgaatgac tggcgcaaag cccagaccga cgaagtgctg gaaaacccgg
0491 acccgcgagg tgcggcatga aacaggtttg cgtcctcggt aacgggcagt taggccgtat gctgcgtcag
0561 gcaggcgaac cgttaggcat tgctgtctgg ccagtcgggc tggacgctga
|
