|
PEC Original Annotations
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|
Essentiality
|
|
Class
|
essential
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|
References (PMID)
|
Gene. 1989;80(1):21-8.
Efficient cloning of a mutant adenylate-kinase-encoding gene from Escherichia coli.
Liang P, Glaser M.
(
2551784
)
|
|
|
Deletion
|
OCR42
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
adk
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
adk
Search strains by all related name:
adk b0474 dnaW ECK0468 JW0463 plsA
|
General information (Go to Linear View: )
|
|
Gene Name
|
adk
|
|
Alternative name
|
b0474,dnaW,ECK0468,JW0463,plsA
|
|
Location, Length
|
496,399 - 497,043
(
+
)
;
10.70
min
;
645
(bp) ,
214
(aa)
|
|
Product
|
adenylate kinase
|
|
Operon Name
|
adk
|
|
Note
|
adenylate kinase activity; pleiotropic effects on glycerol-3-phosphate acyltransferase activity; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion; GO_process: GO:0009152 - purine ribonucleotide biosynthetic process
|
|
Function
|
enzyme; Purine ribonucleotide biosynthesis
|
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( adk )
GO:0004017
;
adenylate kinase activity ( adk )
GO:0005515
;
protein binding ( adk )
GO:0005524
;
ATP binding ( adk )
GO:0005737
;
cytoplasm ( adk )
GO:0006139
;
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process ( adk )
GO:0009165
;
nucleotide biosynthetic process ( adk )
GO:0016301
;
kinase activity ( adk )
GO:0016740
;
transferase activity ( adk )
GO:0016776
;
phosphotransferase activity, phosphate group as acceptor ( adk )
GO:0019201
;
nucleotide kinase activity ( adk )
GO:0019205
;
nucleobase, nucleoside, nucleotide kinase activity ( adk )
|
|
PID
|
1786680
|
EC number
(KEGG Pathway)
|
2.7.4.3
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
adk
(
EG10032
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
KAD_ECOLI
(
P05082
;
P77123
)
|
|
- Protein name
|
Adenylate kinase
|
|
- Synonyms
|
EC 2.7.4.3, ATP-AMP transphosphorylase
|
|
- Gene name
|
OrderedLocusNames=b0474, z0591, ECs0527;
|
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Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
adk
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Adenylate Kinase (E.C.2.7.4.3) Complex With The Inhibitor Ap5a
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Adenylate kinase (ATP-AMP transphosphorylase) (AK)
|
|
PSI-BLAST
|
Adenylate kinase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
adenylate kinase [Escherichia coli]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
ADENYLATE_KINASE
|
|
MMBR References
|
J Bacteriol. 1980;141(1):405-8.
Genetic analysis of Escherichia coli mutants defective in adenylate kinase and sn-glycerol 3-phosphate acyltransferase.
Esmon BE, Kensil CR, Cheng CC, Glaser M.
(
6243627
)
|
Mol Gen Genet. 1982;186(4):488-92.
The Escherichia coli dnaW mutation is an allele of the adk gene.
Henson JM, Blinkowa A, Walker JR.
(
6290847
)
|
Nucleic Acids Res. 1985;13:7139-7151
Cloning and sequencing of the adenylate kinase gene (adk) of Escherichia coli.
Brune, M., R. Schumann, and F. Wittinghofer.
|
| Sequences |
Amino acid
FASTA format
|
0001 MRIILLGAPG AGKGTQAQFI MEKYGIPQIS TGDMLRAAVK SGSELGKQAK DIMDAGKLVT DELVIALVKE
0071 RIAQEDCRNG FLLDGFPRTI PQADAMKEAG INVDYVLEFD VPDELIVDRI VGRRVHAPSG RVYHVKFNPP
0141 KVEGKDDVTG EELTTRKDDQ EETVRKRLVE YHQMTAPLIG YYSKEAEAGN TKYAKVDGTK PVAEVRADLE
0211 KILG
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CCGTTTCAGC CCCAGGTGCC TTTCTTGAGG
-070 CAATCGCCTG TTGGTGGTAT CGTTTATCGC TTTTTCAAAA AATTCGACAC ATTTTAAGGG GATTTTCGCA
0001 atgcgtatca ttctgcttgg cgctccgggc gcggggaaag ggactcaggc tcagttcatc atggagaaat
0071 atggtattcc gcaaatctcc actggcgata tgctgcgtgc tgcggtcaaa tctggctccg agctgggtaa
0141 acaagcaaaa gacattatgg atgctggcaa actggtcacc gacgaactgg tgatcgcgct ggttaaagag
0211 cgcattgctc aggaagactg ccgtaatggt ttcctgttgg acggcttccc gcgtaccatt ccgcaggcag
0281 acgcgatgaa agaagcgggc atcaatgttg attacgttct ggaattcgac gtaccggacg aactgatcgt
0351 tgaccgtatc gtcggtcgcc gcgttcatgc gccgtctggt cgtgtttatc acgttaaatt caatccgccg
0421 aaagtagaag gcaaagacga cgttaccggt gaagaactga ctacccgtaa agatgatcag gaagagaccg
0491 tacgtaaacg tctggttgaa taccatcaga tgacagcacc gctgatcggc tactactcca aagaagcaga
0561 agcgggtaat accaaatacg cgaaagttga cggcaccaag ccggttgctg aagttcgcgc tgatctggaa
0631 aaaatcctcg gctaaTTCGA AAGCGCGCAC GGACAGTCCC CTCGCCCCCT CGGGGAGAGG GTTAGGGTGA
0701 GGGGAACAGG CCCGCACAAG CAAACTTATC AGCAATCTCA GGCCG
|
