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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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OCR40
(D)
,
OCR40-2
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
clpP
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Related strains
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Strains Search
|
Search strains by gene name:
clpP
Search strains by all related name:
clpP b0437 ECK0431 F21.5 JW0427 lopP wseA
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General information (Go to Linear View: )
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Gene Name
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clpP
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Alternative name
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b0437,ECK0431,F21.5,JW0427,lopP,wseA
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Location, Length
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455,901 - 456,524
(
+
)
;
9.83
min
;
624
(bp) ,
207
(aa)
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Product
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proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases
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Operon Name
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clpPX-lon
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Note
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ATP-dependent proteolytic subunit of clpA-clpP serine protease, heat shock protein F21.5; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0008233 - peptidase activity; GO_process: GO:0009266 - response to temperature stimulus
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Function
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enzyme; Degradation of proteins, peptides, glyco
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Gene Ontology
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GO:0004252
;
serine-type endopeptidase activity ( clpP )
GO:0005624
;
membrane fraction ( clpP )
GO:0005737
;
cytoplasm ( clpP )
GO:0006508
;
proteolysis ( clpP )
GO:0006950
;
response to stress ( clpP )
GO:0008233
;
peptidase activity ( clpP )
GO:0008462
;
endopeptidase Clp activity ( clpP )
GO:0016787
;
hydrolase activity ( clpP )
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PID
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1786641
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EC number
(KEGG Pathway)
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3.4.21.92
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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clpP
(
EG10158
)
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Number of removed
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14 aa cleaved
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
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CLPP_ECOLI
(
P19245
)
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- Protein name
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ATP-dependent Clp protease proteolytic subunit
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- Synonyms
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EC 3.4.21.92, Endopeptidase Clp, Caseinolytic protease, Protease Ti, Heat shock protein F21.5
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- Gene name
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OrderedLocusNames=b0437, c0553, z0542, ECs0491, SF0382, S0388;
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MMBR References
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J Bacteriol. 1990;172(10):6026-34.
The ClpP component of Clp protease is the sigma 32-dependent heat shock protein F21.5.
Kroh HE, Simon LD.
(
2211522
)
|
Biochem Soc Trans. 1991;19(3):719-23.
ATP-promoted interaction between Clp A and Clp P in activation of Clp protease from Escherichia coli.
Maurizi MR.
(
1783205
)
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J Biol Chem. 1990;265:12536-12545
Sequence and structure of ClpP, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli.
Maurizi, M. R., W. P. Clark, Y. Katayama, S. Rudikoff, J. Pumphrey, B. Bowers, and S. Gottesman.
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Biochem Biophys Res Commun. 1995;217(1):41-51.
Requirement of ATP hydrolysis for assembly of ClpA/ClpP complex, the ATP-dependent protease Ti in Escherichia coli.
Seol JH, Woo KM, Kang MS, Ha DB, Chung CH.
(
8526938
)
|
J Biol Chem. 1993;268:22609-22617
Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.
Wojkowiak, D., C. Georgopoulos, and M. Zylicz.
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| Sequences |
Amino acid
FASTA format
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0001 MSYSGERDNF APHMALVPMV IEQTSRGERS FDIYSRLLKE RVIFLTGQVE DHMANLIVAQ MLFLEAENPE
0071 KDIYLYINSP GGVITAGMSI YDTMQFIKPD VSTICMGQAA SMGAFLLTAG AKGKRFCLPN SRVMIHQPLG
0141 GYQGQATDIE IHAREILKVK GRMNELMALH TGQSLEQIER DTERDRFLSA PEAVEYGLVD SILTHRN
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ATGGTGATGC CGTACCCATA ACACAGGGAC
-070 TAGCTGATAA TCCGTCCATA AGGTTACAAT CGGTACAGCA GGTTTTTTCA ATTTTATCCA GGAGACGGAA
0001 atgtcataca gcggcgaacg agataacttt gcaccccata tggcgctggt gccgatggtc attgaacaga
0071 cctcacgcgg tgagcgctct tttgatatct attctcgtct acttaaggaa cgcgtcattt ttctgactgg
0141 ccaggttgaa gaccacatgg ctaacctgat tgtggcgcag atgctgttcc tggaagcgga aaacccagaa
0211 aaagatatct atctgtacat taactcccca ggcggggtga tcactgccgg gatgtctatc tatgacacca
0281 tgcagtttat caagcctgat gtcagcacca tctgtatggg ccaggcggcc tcgatgggcg ctttcttgct
0351 gaccgcaggg gcaaaaggta aacgtttttg cctgccgaat tcgcgcgtga tgattcacca accgttgggc
0421 ggctaccagg gccaggcgac cgatatcgaa attcatgccc gtgaaattct gaaagttaaa gggcgcatga
0491 atgaacttat ggcgcttcat acgggtcaat cattagaaca gattgaacgt gataccgagc gcgatcgctt
0561 cctttccgcc cctgaagcgg tggaatacgg tctggtcgat tcgattctga cccatcgtaa ttgaTGCCAG
0631 AGGCGCAACT GTGCCGCTAT ACTTATCCAG GGCGGCACAA CGCTGTAAGC GGCTTGCGCC TGAGAATGGC
0701 ATTTGCGTCG TCGTGTGCGG CACA
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