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PEC Original Annotations
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|
Essentiality
|
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Class
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non-essential
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References (PMID)
|
|
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Deletion
|
DE(deoD-arcA)253
,
OCR26,27-5
(D)
,
OCR27-7
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
trpR
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Related strains
|
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Strains Search
|
Search strains by gene name:
trpR
Search strains by all related name:
trpR aroR aroT b4393 ECK4385 JW4356 o108
|
General information (Go to Linear View: )
|
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Gene Name
|
trpR
|
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Alternative name
|
aroR,aroT,b4393,ECK4385,JW4356,o108
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Location, Length
|
4,630,783 - 4,631,109
(
+
)
;
99.81
min
;
327
(bp) ,
108
(aa)
|
|
Product
|
DNA-binding transcriptional repressor, tryptophan-binding
|
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Operon Name
|
trpR
|
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Note
|
regulator for trp operon and aroH; trp aporepressor; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0000162 - tryptophan biosynthetic process; GO_process: GO:0006350 - transcription
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|
Function
|
regulator; Amino acid biosynthesis: Tryptophan
|
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Gene Ontology
|
GO:0003677
;
DNA binding ( trpR )
GO:0003700
;
transcription factor activity ( trpR )
GO:0005622
;
intracellular ( trpR )
GO:0005737
;
cytoplasm ( trpR )
GO:0006350
;
transcription ( trpR )
GO:0006355
;
regulation of transcription, DNA-dependent ( trpR )
GO:0016564
;
transcription repressor activity ( trpR )
GO:0043565
;
sequence-specific DNA binding ( trpR )
GO:0045892
;
negative regulation of transcription, DNA-dependent ( trpR )
|
|
PID
|
1790854
|
EC number
(KEGG Pathway)
|
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
trpR
(
EG11029
)
|
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Number of removed
|
1 aa cleaved
|
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SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
TRPR_ECOLI
(
P03032
)
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- Protein name
|
Trp operon repressor.
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- Synonyms
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- Gene name
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OrderedLocusNames=b4393, z5995, ECs5351, SF4425, S4696;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
trpR
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain , trp Aporepressor
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
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BLAST
|
Trp operon repressor
|
|
PSI-BLAST
|
Trp operon repressor
|
|
nr
(database updated :
2007.02.20
)
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BLAST
|
Trp operon repressor [Escherichia coli O157:H7 EDL933]
|
|
Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
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PROSITE
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PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
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MMBR References
|
Proc Natl Acad Sci U S A. 1980;77:7117-7121
Nucleotide sequence and expression of Escherichia coli trpR, the structural gene for the trp aporepressor.
Gunsalus, R. P., and C. Yanofsky.
|
J Bacteriol. 1979;140(1):106-13.
Structural and functional analysis of cloned deoxyribonucleic acid containing the trpR-thr region of the Escherichia coli chromosome.
Gunsalus RP, Zurawski G, Yanofsky C.
(
159284
)
|
Genetics 1970;66:31-53
Regulatory mutants of the tryptophan operon of Salmonella typhimurium.
Balbinder, E., R. Callahan, P. P. McCann, J. C. Cordero, R. Weber, A. M. Smith, and F. Angelosanto.
|
C R Acad Sci III. 1993;316(5):469-73.
[A second gene involved in the formation of disulfide bonds in proteins localized in Escherichia coli periplasmic space]
Belin P, Boquet PL.
(
8221229
)
|
Mol Gen Genet. 1979;176(3):361-8.
Cloning the trpR gene.
Roeder W, Somerville RL.
(
160491
)
|
Nucleic Acids Res. 1980;8:1551-1560
DNA sequence of the E. coli trpR gene and prediction of the amino acid sequence of Trp repressor.
Singleton, C. K., W. D. Roeder, G. Bogosian, R. L. Somerville, and H. L. Weith.
|
J Bacteriol. 1994;176:6245-6254
Role of regulatory features of the trp operon of Escherichia coli in mediating a response to a nutritional shift.
Yanofsky, C., and V. Horn.
|
| Sequences |
Amino acid
FASTA format
|
0001 MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE LLRGEMSQRE
0071 LKNELGAGIA TITRGSNSLK AAPVELRQWL EEVLLKSD
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GTCGTTACTG ATCCGCACGT TTATGATATG
-070 CTATCGTACT CTTTAGCGAG TACAACCGGG GGAGGCATTT TGCTTCCCCC GCTAACAATG GCGACATATT
0001 atggcccaac aatcacccta ttcagcagcg atggcagaac agcgtcacca ggagtggtta cgttttgtcg
0071 acctgcttaa gaatgcctac caaaacgatc tccatttacc gttgttaaac ctgatgctga cgccagatga
0141 gcgcgaagcg ttggggactc gcgtgcgtat tgtcgaagag ctgttgcgcg gcgaaatgag ccagcgtgag
0211 ttaaaaaatg aactcggcgc aggcatcgcg acgattacgc gtggatctaa cagcctgaaa gccgcgcccg
0281 tcgagctgcg ccagtggctg gaagaggtgt tgctgaaaag cgattgaTTT TGTAGGCCTG ATAAGACGTG
0351 GCGCATCAGG CATCGTGCAC CGAATGCCGG ATGCGGCGTG AACGCCTTAT CCGTCCTACA AATACCCGTA
0421 ATTTCAA
|
