MG1655
W3110
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Gene Report : pgpA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Microbiol Mol Biol Rev. 1998;62(3):814-984
Linkage map of Escherichia coli K-12, edition 10: the traditional map.
Berlyn MK. ( 9729611 )
     Deletion OCR39 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  pgpA
Related strains
     Strains Search Search strains by gene name:  pgpA   Search strains by all related name:  pgpA b0418 ECK0412 JW0408 o172 yajN

General information  (Go to Linear View:)
 Gene Name pgpA  
 Alternative name b0418,ECK0412,JW0408,o172,yajN  
 Location, Length 435,813 - 436,331 (  +  ) ;   9.39 min ; 519 (bp) ,   172 (aa) Go to Linear View
 Product phosphatidylglycerophosphatase A  
 Operon Name nrdR-ribDE-nusB-thiL-pgpA  
 Note phosphatidylglycerophosphatase; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0008654 - phospholipid biosynthetic process  
 Function enzyme; Macromolecule synthesis, modification: Phospholipids  
 Gene Ontology GO:0005886 ; plasma membrane ( pgpA )
GO:0006629 ; lipid metabolic process ( pgpA )
GO:0008962 ; phosphatidylglycerophosphatase activity ( pgpA )
GO:0009395 ; phospholipid catabolic process ( pgpA )
GO:0016020 ; membrane ( pgpA )
GO:0016021 ; integral to membrane ( pgpA )
GO:0016787 ; hydrolase activity ( pgpA )
 PID 1786620  
 EC number
  (KEGG Pathway)
 
3.1.3.27  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PGPA_ECOLI ( P18200 ; P77321 )
    -  Protein name Phosphatidylglycerophosphatase A  
    -  Synonyms EC 3.1.3.27  
    -  Gene name Name=pgpA; OrderedLocusNames=b0418;  

 Linear View (Whole Mode)
View Location
   425.0  –  450.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP pgpA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
        PSI-BLAST  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Phosphatidylglycerophosphatase A  
         PSI-BLAST Phosphatidylglycerophosphatase A
    nr     (database updated : 2007.02.20 )
         BLAST phosphatidylglycerophosphatase A [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG1267I 
    EcoCyc pgpA 

MMBR References
J Bacteriol. 1992;174:205-213
The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase.
Funk, C. R., L. Zimniak, and W. Dowhan.
J Bacteriol. 1988;170(11):5110-6.
Membrane-bound phosphatases in Escherichia coli: sequence of the pgpA gene.
Icho T. ( 2846510 )
J Bacteriol. 1983;153(2):722-30.
Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors.
Icho T, Raetz CR. ( 6296050 )

Sequences
Amino acid
FASTA format
0001 MTILPRHKDV AKSRLKMSNP WHLLAVGFGS GLSPIVPGTM GSLAAIPFWY LMTFLPWQLY SLVVMLGICI 
0071 GVYLCHQTAK DMGVHDHGSI VWDEFIGMWI TLMALPTNDW QWVAAGFVIF RILDMWKPWP IRWFDRNVHG 
0141 GMGIMIDDIV AGVISAGILY FIGHHWPLGI LS

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             CTGGGCGTAC CGTTTACCTG TATCGGGCAA 
-070 ATGACCGCCG ATATCGAAGG GCTTTGTTTT ATTCGTGACG GCGAACCTGT TACATTAGAC TGGAAAGGAT 
0001 atgaccattt tgccacgcca taaagatgtc gcgaaaagtc gcctgaagat gagtaatccg tggcatctac 
0071 ttgctgtcgg attcggaagt ggattaagcc cgatcgttcc tgggacgatg ggctcgctgg cagcgattcc 
0141 gttctggtat ctgatgacct ttttgccctg gcagctctac tcgctggtgg tgatgctggg gatctgtatc 
0211 ggcgtctatc tttgtcatca aacggcgaaa gacatgggtg tgcacgatca tggcagcatt gtctgggacg 
0281 aatttattgg tatgtggatc acgctcatgg cgctgccgac caatgactgg cagtgggttg ccgccgggtt 
0351 tgtgattttc cgtattctgg atatgtggaa gccgtggccg atccgctggt ttgatcgcaa tgtgcatggc 
0421 ggcatgggga tcatgatcga cgatattgtc gccggggtga tttccgcagg catcctgtat tttatcggtc 
0491 atcactggcc gctgggtatt ctgtcgtagT TGTGCACCGA TGCCTGATGT GACGCTTGTC ACGTCTCATC 
0561 AGGCCTGGAC TCTTATTTAA ATCCTACGAC AGGATGCGGT TTATACGGCG TTTCCAGTT