MG1655
W3110
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Gene Report : melR
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Nucleic Acids Res. 1997;25(9):1685-93.
DNA binding and DNA bending by the MelR transcription activator protein from Escherichia coli.
Bourgerie SJ, Michan CM, Thomas MS, Busby SJ, Hyde EI. ( 9108148 )
     Deletion 4 (LD)  ,  OCR13,15-3 (LD 4E_CRS) (D)  ,  OCR13,15-4 (LD 4E_P/O) (D)  ,  OCR15 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  melR
Related strains
     Strains Search Search strains by gene name:  melR   Search strains by all related name:  melR b4118 ECK4111 f302 JW4079

General information  (Go to Linear View:)
 Gene Name melR  
 Alternative name b4118,ECK4111,f302,JW4079  
 Location, Length 4,338,743 - 4,339,651 (  -  ) ;   93.51 min ; 909 (bp) ,   302 (aa) Go to Linear View
 Product DNA-binding transcriptional dual regulator  
 Operon Name melR  
 Note regulator of melibiose operon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0006350 - transcription  
 Function regulator; Degradation of small molecules: Carbon compounds  
 Gene Ontology GO:0003677 ; DNA binding ( melR )
GO:0003700 ; transcription factor activity ( melR )
GO:0005622 ; intracellular ( melR )
GO:0006350 ; transcription ( melR )
GO:0006355 ; regulation of transcription, DNA-dependent ( melR )
GO:0043565 ; sequence-specific DNA binding ( melR )
GO:0045449 ; regulation of transcription ( melR )
 PID 1790559  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) MELR_ECOLI ( P10411 )
    -  Protein name Melibiose operon regulatory protein.  
    -  Synonyms  
    -  Gene name Name=melR; OrderedLocusNames=b4118, c5123;  

 Linear View (Whole Mode)
View Location
   4330.0  –  4355.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP melR (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, A Model Of The Ternary Complex Formed Between Mara, The Alpha-Ctd Of Rna Polymerase And Dna  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Melibiose operon regulatory protein  
         PSI-BLAST Melibiose operon regulatory protein
    nr     (database updated : 2007.02.20 )
         BLAST DNA-binding transcriptional dual regulator [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    LEUCINE_ZIPPER    HTH_ARAC_FAMILY_1     

Other Cross-Reference
    EcoCyc melR 

MMBR References
J Bacteriol. 1957;73(4):544-52.
Genetic control of raffinose utilization in Escherichia coli.
Lester G, Bonner DM. ( 13428689 )
Nucleic Acids Res. 1997;25:1685-1693
DNA binding and DNA bending by the MelR transcription activator protein from Escherichia coli.
Bourgerie, S. J., C. M. Michan, M. S. Thomas, S. J. Busby, and E. I. Hyde.
Gene. 1987;59(2-3):253-63.
Organisation of the regulatory region of the Escherichia coli melibiose operon.
Webster C, Kempsell K, Booth I, Busby S. ( 2830169 )
Biochem J. 1992;287 (Pt 2):493-9.
Overexpression, purification and characterization of the Escherichia coli MelR transcription activator protein.
Caswell R, Williams J, Lyddiatt A, Busby S. ( 1445207 )

Sequences
Amino acid
FASTA format 
0001 MNTDTFMCSS DEKQTRSPLS LYSEYQRMEI EFRAPHIMPT SHWHGQVEVN VPFDGDVEYL INNEKVNINQ 
0071 GHITLFWACT PHQLTDTGTC QSMAIFNLPM HLFLSWPLDK DLINHVTHGM VIKSLATQQL SPFEVRRWQQ 
0141 ELNSPNEQIR QLAIDEIGLM LKRFSLSGWE PILVNKTSRT HKNSVSRHAQ FYVSQMLGFI AENYDQALTI 
0211 NDVAEHVKLN ANYAMGIFQR VMQLTMKQYI TAMRINHVRA LLSDTDKSIL DIALTAGFRS SSRFYSTFGK 
0281 YVGMSPQQYR KLSQQRRQTF PG
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             cctcgcccct ctgggaagag ggtgaaaacc 
-070 gtgctcccac tcgcagtcat cctccctcac tcctgccata attctgatat tccaggaaag agagccatcc 
0001 atgaatacag atacgtttat gtgcagcagc gacgaaaaac agacccgcag cccgctgtcg ctgtattcgg 
0071 aataccagcg gatggagatt gagtttcgcg caccgcatat catgcccacc agccactggc atggtcaggt 
0141 cgaagtgaat gtgcctttcg atggcgatgt ggaatacctg atcaacaatg aaaaagtgaa tatcaatcag 
0211 ggtcatatca cgctgttctg ggcctgtaca ccgcaccaac taacagatac cggaacctgt cagagcatgg 
0281 cgatttttaa tctgccgatg catctgtttc tctcctggcc gctggataaa gacctgatta accacgtcac 
0351 tcacggcatg gtgatcaaat cactggccac acagcaactt agcccgtttg aagtgcgccg ctggcagcag 
0421 gaattaaaca gtccgaacga gcaaattcgc cagctcgcca ttgatgaaat tggcctgatg ctcaagcgat 
0491 ttagcctctc tggctgggaa ccgattctgg tcaataaaac ctcgcgcaca cacaaaaaca gcgtctcgcg 
0561 ccatgcgcaa ttttatgtta gccagatgct gggctttatt gccgaaaact atgatcaggc gctgaccatc 
0631 aacgatgtgg ctgagcacgt caaacttaac gccaactatg caatggggat attccagcgg gtcatgcaat 
0701 tgacgatgaa acagtacatt accgcgatgc gcatcaacca cgttcgcgcg ttactgagcg ataccgataa 
0771 aagtattctc gatattgccc tgacggcagg ctttcgttca agtagtcgtt tttacagcac gttcggcaaa 
0841 tatgtcggca tgtcgccgca acaataccgc aaacttagcc aacagcgccg ccagacgttt cccggctaaa 
0911 gacgatatca gtatcagcca aaaaaatagt ttagccgtcg ataataagca gtgaaaataa tttaaaataa 
0981 tcacataacg tattgtttat aaaactaaa