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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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4
(LD)
,
OCR13,15-3 (LD 4E_CRS)
(D)
,
OCR13,15-4 (LD 4E_P/O)
(D)
,
OCR14
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
proP
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Related strains
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Strains Search
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Search strains by gene name:
proP
Search strains by all related name:
proP b4111 ECK4104 JW4072
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General information (Go to Linear View: )
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Gene Name
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proP
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Alternative name
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b4111,ECK4104,JW4072
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Location, Length
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4,328,525 - 4,330,027
(
+
)
;
93.29
min
;
1503
(bp) ,
500
(aa)
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Product
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proline/glycine betaine transporter
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Operon Name
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proP
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Note
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low-affinity transport system; proline permease II; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006561 - proline biosynthetic process; GO_process: GO:0006970 - response to osmotic stress
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Function
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transport; Transport of small molecules: Amino acids, amines
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Gene Ontology
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GO:0005215;
transporter activity ( proP )
GO:0005886;
plasma membrane ( proP )
GO:0006810;
transport ( proP )
GO:0015293;
symporter activity ( proP )
GO:0016020;
membrane ( proP )
GO:0016021;
integral to membrane ( proP )
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PID
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1790550
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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PROP_ECOLI
(
P30848
)
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- Protein name
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Proline/betaine transporter
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- Synonyms
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Proline porter II, PPII
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- Gene name
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Name=proP; OrderedLocusNames=b4111, z5713, ECs5093;
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MMBR References
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J Bacteriol. 1985;164(1):434-45.
Identification of osmoresponsive genes in Escherichia coli: evidence for participation of potassium and proline transport systems in osmoregulation.
Gowrishankar J.
(
2995318
)
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J Bacteriol. 1986;166(1):331-3.
proP-mediated proline transport also plays a role in Escherichia coli osmoregulation.
Gowrishankar J.
(
3082857
)
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Mol Gen Genet. 1986;205(2):225-33.
Binding protein dependent transport of glycine betaine and its osmotic regulation in Escherichia coli K12.
May G, Faatz E, Villarejo M, Bremer E.
(
2949137
)
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J Bacteriol. 1995;177:144-151
Two different Escherichia coli proP promoters respond to osmotic and growth phase signals.
Mellies, J., A. Wise, and M. Villarejo.
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J Bacteriol. 1980;141(3):1064-70.
Identification and mapping of a second proline permease Salmonella typhimurium.
Menzel R, Roth J.
(
6245058
)
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Biochim Biophys Acta. 1995;1245(1):116-20.
Competitive accumulation of betaines by Escherichia coli K-12 and derivative strains lacking betaine porters.
Randall K, Lever M, Peddie BA, Chambers ST.
(
7654759
)
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J Bacteriol. 1983;156(2):481-6.
Two proline porters in Escherichia coli K-12.
Stalmach ME, Grothe S, Wood JM.
(
6355059
)
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J Bacteriol. 1995;177:5222-5231
Fis activates the RpoS-dependent stationary-phase expression of proP in Escherichia coli.
Xu, J., and R. C. Johnson.
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J Mol Biol. 1993;229(1):268-76.
Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/betaine transporter, ProP.
Culham DE, Lasby B, Marangoni AG, Milner JL, Steer BA, van Nues RW, Wood JM.
(
8421314
)
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| Sequences |
Amino acid
FASTA format
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0001 MLKRKKVKPI TLRDVTIIDD GKLRKAITAA SLGNAMEWFD FGVYGFVAYA LGKVFFPGAD PSVQMVAALA
0071 TFSVPFLIRP LGGLFFGMLG DKYGRQKILA ITIVIMSIST FCIGLIPSYD TIGIWAPILL LICKMAQGFS
0141 VGGEYTGASI FVAEYSPDRK RGFMGSWLDF GSIAGFVLGA GVVVLISTIV GEANFLDWGW RIPFFIALPL
0211 GIIGLYLRHA LEETPAFQQH VDKLEQGDRE GLQDGPKVSF KEIATKYWRS LLTCIGLVIA TNVTYYMLLT
0281 YMPSYLSHNL HYSEDHGVLI IIAIMIGMLF VQPVMGLLSD RFGRRPFVLL GSVALFVLAI PAFILINSNV
0351 IGLIFAGLLM LAVILNCFTG VMASTLPAMF PTHIRYSALA AAFNISVLVA GLTPTLAAWL VESSQNLMMP
0421 AYYLMVVAVV GLITGVTMKE TANRPLKGAT PAASDIQEAK EILVEHYDNI EQKIDDIDHE IADLQAKRTR
0491 LVQQHPRIDE
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 GTTACAGAGA TTGCATCCTG CAATTCCCGC
-070 TCCCCTTTTG CGGCCGTCGC GCTGATTTTT CTGGCGTTTG CGGAAATGGG CCAACTCTGC GAGGAAAGCT
0001 atgctgaaaa ggaaaaaagt aaaaccgatt acccttcgtg atgtcaccat tattgatgac ggtaaactgc
0071 gtaaagccat taccgcagca tcactgggta atgcaatgga atggttcgat tttggtgttt atggttttgt
0141 tgcttacgca ttaggtaaag tttttttccc gggggctgac cccagcgtgc agatggttgc tgcacttgcc
0211 actttctccg ttccctttct gattcgaccg cttggcggac tcttctttgg tatgttgggc gataaatatg
0281 gtcgccagaa gatcctcgct atcactattg tgattatgtc gatcagtacg ttctgtattg gcttaatacc
0351 gtcctacgac acgattggta tttgggcacc gattctgctg ttgatctgta agatggcaca aggtttctcg
0421 gtcggcggtg aatataccgg ggcgtcgata tttgttgcgg aatactcccc tgaccgtaaa cgtggcttta
0491 tgggcagctg gctggacttc ggttctattg ccgggtttgt gctgggtgcg ggcgtggtgg tgttaatttc
0561 gaccattgtc ggcgaagcga acttcctcga ttggggctgg cgtattccgt tctttatcgc tctgccgtta
0631 gggattatcg ggctttacct gcgccatgcg ctggaagaga ctccggcgtt ccagcagcat gtcgataaac
0701 tggaacaggg cgaccgtgaa ggtttgcagg atggcccgaa agtctcgttt aaagagattg ccactaaata
0771 ctggcgcagc ctgttgacat gtattggtct ggtaattgcc accaacgtga cttactacat gttgctgacc
0841 tatatgccga gttatttgtc gcataacctg cattactccg aagaccacgg ggtgctgatt attatcgcca
0911 ttatgatcgg tatgctgttt gtccagccgg tgatgggctt gctgagtgac cgttttggcc gtcgtccgtt
0981 tgtgctactt ggtagtgttg ccctgtttgt gttggcgatc ccggcgttta ttctgattaa cagtaacgtc
1051 atcggcctga tttttgccgg gttactgatg ctggcggtga tccttaactg ctttacgggc gttatggctt
1121 ctaccttgcc agcgatgttc ccgacgcata tccgttacag cgcgctggcg gcggcattta atatttcggt
1191 gctggttgcc ggtctgacgc caacgctggc ggcctggctg gtcgaaagct cgcagaatct gatgatgcct
1261 gcctattacc tgatggtagt ggcggtggtt ggtttaatca ccggcgtaac catgaaagag acggcaaatc
1331 gtccgttgaa aggtgcgaca ccggcggcgt cagatataca ggaagcgaag gaaattctcg tcgagcatta
1401 cgataatatc gagcagaaaa tcgatgatat tgaccacgag attgccgatt tgcaggcgaa acgtacccgc
1471 ctggtgcagc aacatccgcg aattgatgaa taaGCTGAAA CGGATGGCCT GATGTGACGC TGTCTTATCA
1541 GGCCAATTGA ACTCTTAAGG TTCACTTAAT CTCTGACGCG CATACTCTCC TCCAGGTTAA CGG
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