MG1655
W3110
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Gene Report : thrC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Nucleic Acids Res. 1983;11(21):7331-45.
Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12.
Parsot C, Cossart P, Saint-Girons I, Cohen GN. ( 6316258 )
     Deletion OCR27 (D)  ,  OCR27-1 (D)  ,  OCR27-6 (D)  ,  OCR27-7 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  thrC
Related strains
     Strains Search Search strains by gene name:  thrC   Search strains by all related name:  thrC b0004 ECK0004 JW0003

General information  (Go to Linear View:)
 Gene Name thrC  
 Alternative name b0004,ECK0004,JW0003  
 Location, Length 3,734 - 5,020 (  +  ) ;   0.08 min ; 1287 (bp) ,   428 (aa) Go to Linear View
 Product threonine synthase  
 Operon Name thrLABC  
 Note GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009088 - threonine biosynthetic process  
 Function enzyme; Amino acid biosynthesis: Threonine,1.5.1.8 metabolism; building block biosynthesis; amino acids; threonine,7.1 location of gene products; cytoplasm  
 Gene Ontology GO:0003824; catalytic activity ( thrC )
GO:0004795; threonine synthase activity ( thrC )
GO:0005515; protein binding ( thrC )
GO:0006520; amino acid metabolic process ( thrC )
GO:0008152; metabolic process ( thrC )
GO:0008652; amino acid biosynthetic process ( thrC )
GO:0009088; threonine biosynthetic process ( thrC )
GO:0016829; lyase activity ( thrC )
GO:0030170; pyridoxal phosphate binding ( thrC )
 PID 1786185  
 EC number
  (KEGG Pathway)
 
4.2.3.1  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene thrC ( EG11000 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) THRC_ECOLI ( P00934 )
    -  Protein name Threonine synthase  
    -  Synonyms EC 4.2.3.1  
    -  Gene name Name=thrC; OrderedLocusNames=b0004;  

 Linear View (Whole Mode)
View Location
   0.0  –  25.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP thrC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of Threonine Synthase From Escherichia Coli  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Threonine synthase  
         PSI-BLAST Tryptophan synthase beta chain
    nr     (database updated : 2007.02.20 )
         BLAST threonine synthase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    DEHYDRATASE_SER_THR     

Other Cross-Reference
    COG COG0498E 
    EcoCyc thrC 

MMBR References
J Bacteriol. 1979;140(1):106-13.
Structural and functional analysis of cloned deoxyribonucleic acid containing the trpR-thr region of the Escherichia coli chromosome.
Gunsalus RP, Zurawski G, Yanofsky C. ( 159284 )
Nucleic Acids Res. 1983;11:7331-7345
Nucleotide sequence of thrC and of the termination region of the threonine operon in Escherichia coli K12.
Parsot, C., P. Cossart, I. Saint-Girons, and G. N. Cohen.
Nucleic Acids Res. 1981;9:339-347
Nucleotide sequence of the thrB gene of E. coli, and its two adjacent regions; the thrAB and thrBC junctions.
Cossart, P., M. Katinka, and M. Yaniv.
Mol Gen Genet. 1979;175(1):39-44.
Construction and expression of a hybrid plasmid containing the Escherichia coli thrA and thrB genes.
Cossart P, Katinka M, Yaniv M, Saint Girons I, Cohen GN. ( 390305 )

Sequences
Amino acid
FASTA format
0001 MKLYNLKDHN EQVSFAQAVT QGLGKNQGLF FPHDLPEFSL TEIDEMLKLD FVTRSAKILS AFIGDEIPQE 
0071 ILEERVRAAF AFPAPVANVE SDVGCLELFH GPTLAFKDFG GRFMAQMLTH IAGDKPVTIL TATSGDTGAA 
0141 VAHAFYGLPN VKVVILYPRG KISPLQEKLF CTLGGNIETV AIDGDFDACQ ALVKQAFDDE ELKVALGLNS 
0211 ANSINISRLL AQICYYFEAV AQLPQETRNQ LVVSVPSGNF GDLTAGLLAK SLGLPVKRFI AATNVNDTVP 
0281 RFLHDGQWSP KATQATLSNA MDVSQPNNWP RVEELFRRKI WQLKELGYAA VDDETTQQTM RELKELGYTS 
0351 EPHAAVAYRA LRDQLNPGEY GLFLGTAHPA KFKESVEAIL GETLDLPKEL AERADLPLLS HNLPADFAAL 
0421 RKLMMNHQ

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             CGTTGCCGAC TGGTTGGGTA AGAACTACCT 
-070 GCAAAATCAG GAAGGTTTTG TTCATATTTG CCGGCTGGAT ACGGCGGGCG CACGAGTACT GGAAAACTAA 
0001 atgaaactct acaatctgaa agatcacaac gagcaggtca gctttgcgca agccgtaacc caggggttgg 
0071 gcaaaaatca ggggctgttt tttccgcacg acctgccgga attcagcctg actgaaattg atgagatgct 
0141 gaagctggat tttgtcaccc gcagtgcgaa gatcctctcg gcgtttattg gtgatgaaat cccacaggaa 
0211 atcctggaag agcgcgtgcg cgcggcgttt gccttcccgg ctccggtcgc caatgttgaa agcgatgtcg 
0281 gttgtctgga attgttccac gggccaacgc tggcatttaa agatttcggc ggtcgcttta tggcacaaat 
0351 gctgacccat attgcgggtg ataagccagt gaccattctg accgcgacct ccggtgatac cggagcggca 
0421 gtggctcatg ctttctacgg tttaccgaat gtgaaagtgg ttatcctcta tccacgaggc aaaatcagtc 
0491 cactgcaaga aaaactgttc tgtacattgg gcggcaatat cgaaactgtt gccatcgacg gcgatttcga 
0561 tgcctgtcag gcgctggtga agcaggcgtt tgatgatgaa gaactgaaag tggcgctagg gttaaactcg 
0631 gctaactcga ttaacatcag ccgtttgctg gcgcagattt gctactactt tgaagctgtt gcgcagctgc 
0701 cgcaggagac gcgcaaccag ctggttgtct cggtgccaag cggaaacttc ggcgatttga cggcgggtct 
0771 gctggcgaag tcactcggtc tgccggtgaa acgttttatt gctgcgacca acgtgaacga taccgtgcca 
0841 cgtttcctgc acgacggtca gtggtcaccc aaagcgactc aggcgacgtt atccaacgcg atggacgtga 
0911 gtcagccgaa caactggccg cgtgtggaag agttgttccg ccgcaaaatc tggcaactga aagagctggg 
0981 ttatgcagcc gtggatgatg aaaccacgca acagacaatg cgtgagttaa aagaactggg ctacacttcg 
1051 gagccgcacg ctgccgtagc ttatcgtgcg ctgcgtgatc agttgaatcc aggcgaatat ggcttgttcc 
1121 tcggcaccgc gcatccggcg aaatttaaag agagcgtgga agcgattctc ggtgaaacgt tggatctgcc 
1191 aaaagagctg gcagaacgtg ctgatttacc cttgctttca cataatctgc ccgccgattt tgctgcgttg 
1261 cgtaaattga tgatgaatca tcagtaaAAT CTATTCATTA TCTCAATCAG GCCGGGTTTG CTTTTATGCA 
1331 GCCCGGCTTT TTTATGAAGA AATTATGGAG AAAAATGACA GGGAAAAAGG AGAAATT