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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCR39
(D)
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|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
sbcC
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Related strains
|
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Strains Search
|
Search strains by gene name:
sbcC
Search strains by all related name:
sbcC b0397 ECK0391 JW0387 rmuA
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General information (Go to Linear View: )
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Gene Name
|
sbcC
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Alternative name
|
b0397,ECK0391,JW0387,rmuA
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|
Location, Length
|
411,831 - 414,977
(
-
)
;
8.88
min
;
3147
(bp) ,
1048
(aa)
|
|
Product
|
exonuclease, dsDNA, ATP-dependent
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Operon Name
|
sbcDC
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Note
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ATP-dependent dsDNA exonuclease; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006308 - DNA catabolic process
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Function
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enzyme; Degradation of DNA
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Gene Ontology
|
GO:0000166
;
nucleotide binding ( sbcC )
GO:0004518
;
nuclease activity ( sbcC )
GO:0004519
;
endonuclease activity ( sbcC )
GO:0004527
;
exonuclease activity ( sbcC )
GO:0005515
;
protein binding ( sbcC )
GO:0005524
;
ATP binding ( sbcC )
GO:0005694
;
chromosome ( sbcC )
GO:0006259
;
DNA metabolic process ( sbcC )
GO:0006260
;
DNA replication ( sbcC )
GO:0006310
;
DNA recombination ( sbcC )
GO:0016787
;
hydrolase activity ( sbcC )
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PID
|
1786597
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EC number
(KEGG Pathway)
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|
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
|
SBCC_ECOLI
(
P13458
)
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|
- Protein name
|
Exonuclease sbcC.
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- Synonyms
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- Gene name
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Name=sbcC; Synonyms=rmuA; OrderedLocusNames=b0397;
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Homology Analysis
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BLAST
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|
Bacteria
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GTOP
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sbcC
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
|
Chain A, Cryo-Em Structure Of Chicken Gizzard Smooth Muscle Alpha- Actinin
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Exonuclease sbcC
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PSI-BLAST
|
Myosin-2
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nr
(database updated :
2007.02.20
)
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BLAST
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exonuclease, dsDNA, ATP-dependent [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
ATP_GTP_A
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MMBR References
|
Genetica. 1992;87(2):95-100.
The SbcCD protein of Escherichia coli is related to two putative nucleases in the UvrA superfamily of nucleotide-binding proteins.
Leach DR, Lloyd RG, Coulson AF.
(
1490631
)
|
J Bacteriol. 1991;173(18):5694-8.
Linkage distortion following conjugational transfer of sbcC+ to recBC sbcBC strains of Escherichia coli.
Lloyd RG.
(
1885546
)
|
J Bacteriol. 1985;164(2):836-44.
Identification and genetic analysis of sbcC mutations in commonly used recBC sbcB strains of Escherichia coli K-12.
Lloyd RG, Buckman C.
(
3932331
)
|
Nucleic Acids Res. 1989;17:8033-8044
Molecular organization of sbcC, a gene that affects genetic recombination and the viability of DNA palindromes in Escherichia coli K-12.
Naom, I. S., S. J. Morton, D. R. F. Leach, and R. G. Lloyd.
|
Genetics 1996;143:27-36
Orientation dependence in homologous recombination.
Yamamoto, K., N. Takahashi, Y. Fujitani, H. Yoshikura, and I. Kobayashi.
|
J Bacteriol. 1989;171(7):4071-2.
Methionine aminopeptidase gene of Escherichia coli is essential for cell growth.
Chang SY, McGary EC, Chang S.
(
2544569
)
|
Genes Cells 1996;1:285-291
The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination.
Connelly, J. C., and D. R. Leach.
|
| Sequences |
Amino acid
FASTA format
|
0001 MKILSLRLKN LNSLKGEWKI DFTREPFASN GLFAITGPTG AGKTTLLDAI CLALYHETPR LSNVSQSQND
0071 LMTRDTAECL AEVEFEVKGE AYRAFWSQNR ARNQPDGNLQ VPRVELARCA DGKILADKVK DKLELTATLT
0141 GLDYGRFTRS MLLSQGQFAA FLNAKPKERA ELLEELTGTE IYGQISAMVF EQHKSARTEL EKLQAQASGV
0211 TLLTPEQVQS LTASLQVLTD EEKQLITAQQ QEQQSLNWLT RQDELQQEAS RRQQALQQAL AEEEKAQPQL
0281 AALSLAQPAR NLRPHWERIA EHSAALAHIR QQIEEVNTRL QSTMALRASI RHHAAKQSAE LQQQQQSLNT
0351 WLQEHDRFRQ WNNEPAGWRA QFSQQTSDRE HLRQWQQQLT HAEQKLNALA AITLTLTADE VATALAQHAE
0421 QRPLRQHLVA LHGQIVPQQK RLAQLQVAIQ NVTQEQTQRN AALNEMRQRY KEKTQQLADV KTICEQEARI
0491 KTLEAQRAQL QAGQPCPLCG STSHPAVEAY QALEPGVNQS RLLALENEVK KLGEEGATLR GQLDAITKQL
0561 QRDENEAQSL RQDEQALTQQ WQAVTASLNI TLQPLDDIQP WLDAQDEHER QLRLLSQRHE LQGQIAAHNQ
0631 QIIQYQQQIE QRQQLLLTTL TGYALTLPQE DEEESWLATR QQEAQSWQQR QNELTALQNR IQQLTPILET
0701 LPQSDELPHC EETVVLENWR QVHEQCLALH SQQQTLQQQD VLAAQSLQKA QAQFDTALQA SVFDDQQAFL
0771 AALMDEQTLT QLEQLKQNLE NQRRQAQTLV TQTAETLAQH QQHRPDDGLA LTVTVEQIQQ ELAQTHQKLR
0841 ENTTSQGEIR QQLKQDADNR QQQQTLMQQI AQMTQQVEDW GYLNSLIGSK EGDKFRKFAQ GLTLDNLVHL
0911 ANQQLTRLHG RYLLQRKASE ALEVEVVDTW QADAVRDTRT LSGGESFLVS LALALALSDL VSHKTRIDSL
0981 FLDEGFGTLD SETLDTALDA LDALNASGKT IGVISHVEAM KERIPVQIKV KKINGLGYSK LESTFAVK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 atcgccgtct ggcactggaa gaactggatg
-070 aatcgcagca gcaacgtctg cagcatcttt tcaccacgac gttgcatacc ctcgccggag aacacgaagc
0001 atgaaaattc tcagcctgcg cctgaaaaac ctgaactcat taaaaggcga atggaagatt gatttcaccc
0071 gcgagccgtt cgccagcaac gggctgtttg ctattaccgg cccaacaggt gcggggaaaa ccaccctgct
0141 ggacgccatt tgtctggcgc tgtatcacga aactccgcgt ctctctaacg tttcacaatc gcaaaatgat
0211 ctcatgaccc gcgataccgc cgaatgtctg gcggaggtgg agtttgaagt gaaaggtgaa gcgtaccgtg
0281 cattctggag ccagaatcgg gcgcgtaacc aacccgacgg taatttgcag gtgccacgcg tagagctggc
0351 gcgctgcgcc gacggcaaaa ttctcgccga caaagtgaaa gataagctgg aactgacagc gacgttaacc
0421 gggctggatt acgggcgctt cacccgttcg atgctgcttt cgcaggggca atttgctgcc ttcctgaatg
0491 ccaaacccaa agaacgcgcg gaattgctcg aggagttaac cggcactgaa atctacgggc aaatctcggc
0561 gatggttttt gagcagcaca aatcggcccg cacagagctg gagaagctgc aagcgcaggc cagcggcgtc
0631 acgttgctca cgccggaaca agtgcaatcg ctgacagcga gtttgcaggt acttactgac gaagaaaaac
0701 agttaattac cgcgcagcag caagaacaac aatcgctaaa ctggttaacg cgtcaggacg aattgcagca
0771 agaagccagc cgccgtcagc aggccttgca acaggcgtta gccgaagaag aaaaagcgca acctcaactg
0841 gcggcgctta gtctggcaca accggcacga aatcttcgtc cacactggga acgcatcgca gaacacagcg
0911 cggcgctggc gcatattcgc cagcagattg aagaagtaaa tactcgctta cagagcacaa tggcgcttcg
0981 cgcgagcatt cgccaccacg cggcgaagca gtcagcagaa ttacagcagc agcaacaaag cctgaatacc
1051 tggttacagg aacacgaccg cttccgtcag tggaacaacg aaccggcggg ttggcgtgcg cagttctccc
1121 aacaaaccag cgatcgcgag catctgcggc aatggcagca acagttaacc catgctgagc aaaaacttaa
1191 tgcgcttgcg gcgatcacgt tgacgttaac cgccgatgaa gttgctaccg ccctggcgca acatgctgag
1261 caacgcccac tgcgtcagca cctggtcgcg ctgcatggac agattgttcc ccaacaaaaa cgtctggcgc
1331 agttacaggt cgctatccag aatgtcacgc aagaacagac gcaacgtaac gccgcactta acgaaatgcg
1401 ccagcgttat aaagaaaaga cgcagcaact tgccgatgtg aaaaccattt gcgagcagga agcgcgcatc
1471 aaaacgctgg aagctcaacg tgcacagtta caggcgggtc agccttgccc actttgtggt tccaccagcc
1541 acccggcggt cgaggcgtat caggcgctgg agcctggcgt taatcagtct cgattactgg cgctggaaaa
1611 cgaagttaaa aagctcggtg aagaaggtgc gacgctacgt gggcaactgg acgccataac aaagcagctt
1681 cagcgtgatg aaaacgaagc gcaaagcctc cgacaagatg agcaagcact tactcaacaa tggcaagccg
1751 tcacggccag cctcaatatc accttgcagc cactggacga tattcaaccg tggctggatg cacaagatga
1821 gcacgaacgc cagctgcggt tactcagcca acggcatgaa ttacaagggc agattgccgc gcataatcag
1891 caaattatcc agtatcaaca gcaaattgaa caacgccagc aactactttt aacgacattg acgggttatg
1961 cactgacatt gccacaggaa gatgaagaag agagctggtt ggcgacacgt cagcaagaag cgcagagctg
2031 gcagcaacgc cagaacgaat taaccgcgct gcaaaaccgt attcagcagc tgacgccgat tctggaaacg
2101 ttgccgcaaa gtgatgaact cccgcactgc gaagaaactg tggtattgga aaactggcgg caggtacatg
2171 aacaatgtct cgcattacac agccagcagc agacgttaca gcaacaggat gttctggcgg cgcaaagtct
2241 gcaaaaagcc caggcgcagt ttgacaccgc gctacaggcc agcgtctttg acgatcagca ggcgttcctt
2311 gcggcgctaa tggatgaaca aacactaacg cagctggaac agctcaagca gaatctggaa aaccagcgcc
2381 gtcaggcgca aactctggtc actcagacag cagaaacgct ggcacagcat caacaacacc gacctgacga
2451 cgggttggct ctcactgtga cggtggagca gattcagcaa gagttagcgc aaactcacca aaagttgcgt
2521 gaaaacacca cgagtcaagg cgagattcgc cagcagctga agcaggatgc agataaccgt cagcaacaac
2591 aaaccttaat gcagcaaatt gctcaaatga cgcagcaggt tgaggactgg ggatatctga attcgctaat
2661 aggttccaaa gagggcgata aattccgcaa gtttgcccag gggctgacgc tggataattt agtccatctc
2731 gctaatcagc aacttacccg gctgcacggg cgctatctgt tacagcgcaa agccagcgag gcgctggaag
2801 tcgaggttgt tgatacctgg caggcagatg cggtacgcga tacccgtacc ctttccggcg gcgaaagttt
2871 cctcgttagt ctggcgctgg cgctggcgct ttcggatctg gtcagccata aaacacgtat tgactcgctg
2941 ttccttgatg aaggttttgg cacgctggat agcgaaacgc tggataccgc ccttgatgcg ctggatgccc
3011 tgaacgccag tggcaaaacc atcggtgtga ttagccacgt agaagcgatg aaagagcgta ttccggtgca
3081 gatcaaagtg aaaaagatca acggcctggg ctacagcaaa ctggaaagta cgtttgcagt gaaataacta
3151 ttcagcagga taatgaatac agaggggcga attatctctt ggccttgctg gtcgttatcc tgcaagctat
3221 cactttattg gctacggtga ttggtag
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