MG1655
W3110
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Gene Report : lamB
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion OCR12 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  lamB
Related strains
     Strains Search Search strains by gene name:  lamB   Search strains by all related name:  lamB b4036 ECK4028 JW3996 malB malL o446

General information  (Go to Linear View:)
 Gene Name lamB  
 Alternative name b4036,ECK4028,JW3996,malB,malL,o446  
 Location, Length 4,245,994 - 4,247,334 (  +  ) ;   91.51 min ; 1341 (bp) ,   446 (aa) Go to Linear View
 Product maltose outer membrane porin (maltoporin)  
 Operon Name malK-lamB-malM  
 Note phage lambda receptor protein; maltose high-affinity receptor; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0009279 - cell outer membrane  
 Function IS, phage, Tn; Transport of small molecules: Carbohydrates, organic acids, alcohols  
 Gene Ontology GO:0005351 ; sugar:hydrogen ion symporter activity ( lamB )
GO:0006810 ; transport ( lamB )
GO:0006811 ; ion transport ( lamB )
GO:0008643 ; carbohydrate transport ( lamB )
GO:0009279 ; cell outer membrane ( lamB )
GO:0009597 ; detection of virus ( lamB )
GO:0015288 ; porin activity ( lamB )
GO:0015768 ; maltose transport ( lamB )
GO:0016020 ; membrane ( lamB )
GO:0016021 ; integral to membrane ( lamB )
GO:0019867 ; outer membrane ( lamB )
GO:0046718 ; entry of virus into host cell ( lamB )
 PID 1790469  
 EC number
  (KEGG Pathway)
 
 
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene lamB ( EG10528 )  
    Number of removed 25 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) LAMB_ECOLI ( P02943 )
    -  Protein name Maltoporin precursor  
    -  Synonyms Maltose-inducible porin, Lambda receptor protein  
    -  Gene name Name=lamB; Synonyms=malB; OrderedLocusNames=b4036;  

 Linear View (Whole Mode)
View Location
   4235.0  –  4260.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP lamB (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Mol_id: 1; Molecule: Maltoporin; Chain: Null; Synonym: Lamb  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Maltoporin precursor  
         PSI-BLAST Maltoporin precursor
    nr     (database updated : 2007.02.20 )
         BLAST maltoporin precursor [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    RGD     

Other Cross-Reference
    EcoCyc lamB 

MMBR References
Nature. 1980;285(5760):82-5.
Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein.
Emr SD, Hedgpeth J, Clement JM, Silhavy TJ, Hofnung M. ( 6445509 )
Proc Natl Acad Sci U S A. 1980;77:2621-2625
DNA sequence encoding the NH2-terminal peptide involved in transport of receptor, an Escherichia coli secretory protein.
Hedgpeth, J., J. M. Clement, C. Marchal, D. M. Perrin, and M. Hofnung.
Mol Gen Genet. 1976;145(2):207-13.
lamB mutations in E. coli K12: growth of lambda host range mutants and effect of nonsense suppressors.
Hofnung M, Jezierska A, Braun-Breton C. ( 778586 )
J Bacteriol. 1981;148(3):853-60.
General method for fine mapping of the Escherichia coli K-12 lamB gene: localization of missense mutations affecting bacteriophage lambda adsorption.
Hofnung M, Lepouce E, Braun-Breton C. ( 6458595 )
Mol Gen Genet. 1971;112(2):117-32.
Mutations allowing growth on maltose of Escherichia coli K 12 strains with a deleted malT gene.
Hofnung M, Schwartz M. ( 4940111 )
Proc Natl Acad Sci U S A. 1981;78:2937-2941
Mutations that affect lamB gene expression at a posttranscriptional level.
Schwartz, M., M. Roa, and M. Debarbouille.
Genetics 1972;71:207-216
On some genetic aspects of phage lambda resistance in E. coli K12.
Thirion, J. P., and M. Hofnung.
J Bacteriol. 1981;148(3):845-52.
In vivo and in vitro functional alterations of the bacteriophage lambda receptor in lamB missense mutants of Escherichia coli K-12.
Braun-Breton C, Hofnung M. ( 6458594 )
Cell. 1981;27(3 Pt 2):507-14.
Gene sequence of the lambda receptor, an outer membrane protein of E. coli K12.
Clement JM, Hofnung M. ( 6086106 )
Mol Gen Genet. 1981;184(3):479-83.
rho Mutations restore lamB expression in E. coli K12 strains with an inactive malB region.
Colonna B, Hofnung M. ( 6278260 )
J Bacteriol. 1993;175:1475-1483
Derepression of LamB protein facilitates outer membrane permeation of carbohydrates into Escherichia coli under conditions of nutrient stress.
Death, A., L. Notley, and T. Ferenci.

Sequences
Amino acid
FASTA format
0001 MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQT TGAQSKYRLG NECETYAELK 
0071 LGQEVWKEGD KSFYFDTNVA YSVAQQNDWE ATDPAFREAN VQGKNLIEWL PGSTIWAGKR FYQRHDVHMI 
0141 DFYYWDISGP GAGLENIDVG FGKLSLAATR SSEAGGSSSF ASNNIYDYTN ETANDVFDVR LAQMEINPGG 
0211 TLELGVDYGR ANLRDNYRLV DGASKDGWLF TAEHTQSVLK GFNKFVVQYA TDSMTSQGKG LSQGSGVAFD 
0281 NEKFAYNINN NGHMLRILDH GAISMGDNWD MMYVGMYQDI NWDNDNGTKW WTVGIRPMYK WTPIMSTVME 
0351 IGYDNVESQR TGDKNNQYKI TLAQQWQAGD SIWSRPAIRV FATYAKWDEK WGYDYTGNAD NNANFGKAVP 
0421 ADFNGGSFGR GDSDEWTFGA QMEIWW

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GTCGACTGCA TAAGGAGCCG GGCGTTTAAG 
-070 CACCCCACAA AACACACAAA GCCTGTCACA GGTGATGTGA AAAAAGAAAA GCAATGACTC AGGAGATAGA 
0001 atgatgatta ctctgcgcaa acttcctctg gcggttgccg tcgcagcggg cgtaatgtct gctcaggcaa 
0071 tggctgttga tttccacggc tatgcacgtt ccggtattgg ttggacaggt agcggcggtg aacaacagtg 
0141 tttccagact accggtgctc aaagtaaata ccgtcttggc aacgaatgtg aaacttatgc tgaattaaaa 
0211 ttgggtcagg aagtgtggaa agagggcgat aagagcttct atttcgacac taacgtggcc tattccgtcg 
0281 cacaacagaa tgactgggaa gctaccgatc cggccttccg tgaagcaaac gtgcagggta aaaacctgat 
0351 cgaatggctg ccaggctcca ccatctgggc aggtaagcgc ttctaccaac gtcatgacgt tcatatgatc 
0421 gacttctact actgggatat ttctggtcct ggtgccggtc tggaaaacat cgatgttggc ttcggtaaac 
0491 tctctctggc agcaacccgc tcctctgaag ctggtggttc ttcctctttc gccagcaaca atatttatga 
0561 ctataccaac gaaaccgcga acgacgtttt cgatgtgcgt ttagcgcaga tggaaatcaa cccgggcggc 
0631 acattagaac tgggtgtcga ctacggtcgt gccaacttgc gtgataacta tcgtctggtt gatggcgcat 
0701 cgaaagacgg ctggttattc actgctgaac atactcagag tgtcctgaag ggctttaaca agtttgttgt 
0771 tcagtacgct actgactcga tgacctcgca gggtaaaggg ctgtcgcagg gttctggcgt tgcatttgat 
0841 aacgaaaaat ttgcctacaa tatcaacaac aacggtcaca tgctgcgtat cctcgaccac ggtgcgatct 
0911 ccatgggcga caactgggac atgatgtacg tgggtatgta ccaggatatc aactgggata acgacaacgg 
0981 caccaagtgg tggaccgtcg gtattcgccc gatgtacaag tggacgccaa tcatgagcac cgtgatggaa 
1051 atcggctacg acaacgtcga atcccagcgc accggcgaca agaacaatca gtacaaaatt accctcgcac 
1121 aacaatggca ggctggcgac agcatctggt cacgcccggc tattcgtgtc ttcgcaacct acgccaagtg 
1191 ggatgagaaa tggggttacg actacaccgg taacgctgat aacaacgcga acttcggcaa agccgttcct 
1261 gctgatttca acggcggcag cttcggtcgt ggcgacagcg acgagtggac cttcggtgcc cagatggaaa 
1331 tctggtggta aTAGCAAAAC CTGGGCCGGA TAAGGCGTTT ACGCCGCATT CGGCAACCAA CGCCTGATGC 
1401 GACGCTTGCG CGTCTTATCA GGCCTACAAC GGCTGTCAAA T