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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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OCR12
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
lamB
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Related strains
|
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Strains Search
|
Search strains by gene name:
lamB
Search strains by all related name:
lamB b4036 ECK4028 JW3996 malB malL o446
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General information (Go to Linear View: )
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Gene Name
|
lamB
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Alternative name
|
b4036,ECK4028,JW3996,malB,malL,o446
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Location, Length
|
4,245,994 - 4,247,334
(
+
)
;
91.51
min
;
1341
(bp) ,
446
(aa)
|
|
Product
|
maltose outer membrane porin (maltoporin)
|
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Operon Name
|
malK-lamB-malM
|
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Note
|
phage lambda receptor protein; maltose high-affinity receptor; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0009279 - cell outer membrane
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Function
|
IS, phage, Tn; Transport of small molecules: Carbohydrates, organic acids, alcohols
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Gene Ontology
|
GO:0005351
;
sugar:hydrogen ion symporter activity ( lamB )
GO:0006810
;
transport ( lamB )
GO:0006811
;
ion transport ( lamB )
GO:0008643
;
carbohydrate transport ( lamB )
GO:0009279
;
cell outer membrane ( lamB )
GO:0009597
;
detection of virus ( lamB )
GO:0015288
;
porin activity ( lamB )
GO:0015768
;
maltose transport ( lamB )
GO:0016020
;
membrane ( lamB )
GO:0016021
;
integral to membrane ( lamB )
GO:0019867
;
outer membrane ( lamB )
GO:0046718
;
entry of virus into host cell ( lamB )
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PID
|
1790469
|
EC number
(KEGG Pathway)
|
|
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
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EcoGene
|
lamB
(
EG10528
)
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Number of removed
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25 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
LAMB_ECOLI
(
P02943
)
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- Protein name
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Maltoporin precursor
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- Synonyms
|
Maltose-inducible porin, Lambda receptor protein
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- Gene name
|
Name=lamB; Synonyms=malB; OrderedLocusNames=b4036;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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lamB
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
|
Chain , Mol_id: 1; Molecule: Maltoporin; Chain: Null; Synonym: Lamb
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|
SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Maltoporin precursor
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|
PSI-BLAST
|
Maltoporin precursor
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|
nr
(database updated :
2007.02.20
)
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BLAST
|
maltoporin precursor [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
|
ASN_GLYCOSYLATION
GLYCOSAMINOGLYCAN
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
RGD
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MMBR References
|
Nature. 1980;285(5760):82-5.
Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein.
Emr SD, Hedgpeth J, Clement JM, Silhavy TJ, Hofnung M.
(
6445509
)
|
Proc Natl Acad Sci U S A. 1980;77:2621-2625
DNA sequence encoding the NH2-terminal peptide involved in transport of receptor, an Escherichia coli secretory protein.
Hedgpeth, J., J. M. Clement, C. Marchal, D. M. Perrin, and M. Hofnung.
|
Mol Gen Genet. 1976;145(2):207-13.
lamB mutations in E. coli K12: growth of lambda host range mutants and effect of nonsense suppressors.
Hofnung M, Jezierska A, Braun-Breton C.
(
778586
)
|
J Bacteriol. 1981;148(3):853-60.
General method for fine mapping of the Escherichia coli K-12 lamB gene: localization of missense mutations affecting bacteriophage lambda adsorption.
Hofnung M, Lepouce E, Braun-Breton C.
(
6458595
)
|
Mol Gen Genet. 1971;112(2):117-32.
Mutations allowing growth on maltose of Escherichia coli K 12 strains with a deleted malT gene.
Hofnung M, Schwartz M.
(
4940111
)
|
Proc Natl Acad Sci U S A. 1981;78:2937-2941
Mutations that affect lamB gene expression at a posttranscriptional level.
Schwartz, M., M. Roa, and M. Debarbouille.
|
Genetics 1972;71:207-216
On some genetic aspects of phage lambda resistance in E. coli K12.
Thirion, J. P., and M. Hofnung.
|
J Bacteriol. 1981;148(3):845-52.
In vivo and in vitro functional alterations of the bacteriophage lambda receptor in lamB missense mutants of Escherichia coli K-12.
Braun-Breton C, Hofnung M.
(
6458594
)
|
Cell. 1981;27(3 Pt 2):507-14.
Gene sequence of the lambda receptor, an outer membrane protein of E. coli K12.
Clement JM, Hofnung M.
(
6086106
)
|
Mol Gen Genet. 1981;184(3):479-83.
rho Mutations restore lamB expression in E. coli K12 strains with an inactive malB region.
Colonna B, Hofnung M.
(
6278260
)
|
J Bacteriol. 1993;175:1475-1483
Derepression of LamB protein facilitates outer membrane permeation of carbohydrates into Escherichia coli under conditions of nutrient stress.
Death, A., L. Notley, and T. Ferenci.
|
| Sequences |
Amino acid
FASTA format
|
0001 MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQT TGAQSKYRLG NECETYAELK
0071 LGQEVWKEGD KSFYFDTNVA YSVAQQNDWE ATDPAFREAN VQGKNLIEWL PGSTIWAGKR FYQRHDVHMI
0141 DFYYWDISGP GAGLENIDVG FGKLSLAATR SSEAGGSSSF ASNNIYDYTN ETANDVFDVR LAQMEINPGG
0211 TLELGVDYGR ANLRDNYRLV DGASKDGWLF TAEHTQSVLK GFNKFVVQYA TDSMTSQGKG LSQGSGVAFD
0281 NEKFAYNINN NGHMLRILDH GAISMGDNWD MMYVGMYQDI NWDNDNGTKW WTVGIRPMYK WTPIMSTVME
0351 IGYDNVESQR TGDKNNQYKI TLAQQWQAGD SIWSRPAIRV FATYAKWDEK WGYDYTGNAD NNANFGKAVP
0421 ADFNGGSFGR GDSDEWTFGA QMEIWW
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GTCGACTGCA TAAGGAGCCG GGCGTTTAAG
-070 CACCCCACAA AACACACAAA GCCTGTCACA GGTGATGTGA AAAAAGAAAA GCAATGACTC AGGAGATAGA
0001 atgatgatta ctctgcgcaa acttcctctg gcggttgccg tcgcagcggg cgtaatgtct gctcaggcaa
0071 tggctgttga tttccacggc tatgcacgtt ccggtattgg ttggacaggt agcggcggtg aacaacagtg
0141 tttccagact accggtgctc aaagtaaata ccgtcttggc aacgaatgtg aaacttatgc tgaattaaaa
0211 ttgggtcagg aagtgtggaa agagggcgat aagagcttct atttcgacac taacgtggcc tattccgtcg
0281 cacaacagaa tgactgggaa gctaccgatc cggccttccg tgaagcaaac gtgcagggta aaaacctgat
0351 cgaatggctg ccaggctcca ccatctgggc aggtaagcgc ttctaccaac gtcatgacgt tcatatgatc
0421 gacttctact actgggatat ttctggtcct ggtgccggtc tggaaaacat cgatgttggc ttcggtaaac
0491 tctctctggc agcaacccgc tcctctgaag ctggtggttc ttcctctttc gccagcaaca atatttatga
0561 ctataccaac gaaaccgcga acgacgtttt cgatgtgcgt ttagcgcaga tggaaatcaa cccgggcggc
0631 acattagaac tgggtgtcga ctacggtcgt gccaacttgc gtgataacta tcgtctggtt gatggcgcat
0701 cgaaagacgg ctggttattc actgctgaac atactcagag tgtcctgaag ggctttaaca agtttgttgt
0771 tcagtacgct actgactcga tgacctcgca gggtaaaggg ctgtcgcagg gttctggcgt tgcatttgat
0841 aacgaaaaat ttgcctacaa tatcaacaac aacggtcaca tgctgcgtat cctcgaccac ggtgcgatct
0911 ccatgggcga caactgggac atgatgtacg tgggtatgta ccaggatatc aactgggata acgacaacgg
0981 caccaagtgg tggaccgtcg gtattcgccc gatgtacaag tggacgccaa tcatgagcac cgtgatggaa
1051 atcggctacg acaacgtcga atcccagcgc accggcgaca agaacaatca gtacaaaatt accctcgcac
1121 aacaatggca ggctggcgac agcatctggt cacgcccggc tattcgtgtc ttcgcaacct acgccaagtg
1191 ggatgagaaa tggggttacg actacaccgg taacgctgat aacaacgcga acttcggcaa agccgttcct
1261 gctgatttca acggcggcag cttcggtcgt ggcgacagcg acgagtggac cttcggtgcc cagatggaaa
1331 tctggtggta aTAGCAAAAC CTGGGCCGGA TAAGGCGTTT ACGCCGCATT CGGCAACCAA CGCCTGATGC
1401 GACGCTTGCG CGTCTTATCA GGCCTACAAC GGCTGTCAAA T
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