MG1655
W3110
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Gene Report : argC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion OCR10 (D)  ,  DE(ppc-argH)486  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  argC
Related strains
     Strains Search Search strains by gene name:  argC   Search strains by all related name:  argC Arg2 argH b3958 ECK3949 JW3930

General information  (Go to Linear View:)
 Gene Name argC  
 Alternative name Arg2,argH,b3958,ECK3949,JW3930  
 Location, Length 4,153,024 - 4,154,028 (  +  ) ;   89.51 min ; 1005 (bp) ,   334 (aa) Go to Linear View
 Product N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding  
 Operon Name argCBH  
 Note N-acetyl-gamma-glutamylphosphate reductase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006526 - arginine biosynthetic process  
 Function enzyme; Amino acid biosynthesis: Arginine  
 Gene Ontology GO:0003824 ; catalytic activity ( argC )
GO:0003824 ; catalytic activity ( argH )
GO:0003942 ; N-acetyl-gamma-glutamyl-phosphate reductase activity ( argC )
GO:0004056 ; argininosuccinate lyase activity ( argH )
GO:0005488 ; binding ( argC )
GO:0005737 ; cytoplasm ( argC )
GO:0005737 ; cytoplasm ( argH )
GO:0006520 ; amino acid metabolic process ( argC )
GO:0006526 ; arginine biosynthetic process ( argC )
GO:0006526 ; arginine biosynthetic process ( argH )
GO:0008152 ; metabolic process ( argC )
GO:0008652 ; amino acid biosynthetic process ( argC )
GO:0008652 ; amino acid biosynthetic process ( argH )
GO:0016491 ; oxidoreductase activity ( argC )
GO:0016620 ; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ( argC )
GO:0016829 ; lyase activity ( argH )
GO:0042450 ; arginine biosynthetic process via ornithine ( argH )
GO:0046983 ; protein dimerization activity ( argC )
GO:0051287 ; NAD binding ( argC )
 PID 1790396  
 EC number
  (KEGG Pathway)
 
1.2.1.38  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) ARGC_ECOLI ( P11446 )
    -  Protein name N-acetyl-gamma-glutamyl-phosphate reductase  
    -  Synonyms EC 1.2.1.38, AGPR, N- acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase  
    -  Gene name Name=argC; OrderedLocusNames=b3958;  

 Linear View (Whole Mode)
View Location
   4140.0  –  4165.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP argC (  homologous genes of other bacterias  )   argH (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, The Structure Of N-Acetyl-Gamma-Glutamyl-Phosphate Reductase From Salmonella Typhimurium  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST N-acetyl-gamma-glutamyl-phosphate reductase  
         PSI-BLAST N-acetyl-gamma-glutamyl-phosphate reductase
    nr     (database updated : 2007.02.20 )
         BLAST N-acetyl-gamma-glutamyl-phosphate reductase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    ZINC_PROTEASE    ARGC     

Other Cross-Reference
    COG COG0002E 
    EcoCyc argC 

MMBR References
In K. D. MacDonald (ed.), Proceedings of the Second International Symposium on Genetics and Industrial Microorganisms. Academic Press, London, United Kingdom. 1976:369-389
Genetic control of arginine metabolism in prokaryotes.
Baumberg, S.
Gene. 1979;8(1):25-34.
Clustered arg genes on a BamHI segment of the Escherichia coli chromosome.
Moran MC, Mazaitis AJ, Vogel RH, Vogel HJ. ( 231541 )
J Bacteriol. 1982;151(1):62-7.
Promoter mapping and selection of operator mutants by using insertion of bacteriophage Mu in the argECBH divergent operon of Escherichia coli K-12.
Beny G, Boyen A, Charlier D, Lissens W, Feller A, Glansdorff N. ( 6211434 )
Gene. 1988;68(2):275-83.
Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes.
Parsot C, Boyen A, Cohen GN, Glansdorff N. ( 2851495 )
Nucleic Acids Res. 1982;10:8031-8048
The regulatory region of the divergent argECBH operon in Escherichia coli K-12.
Piette, J., R. Cunin, A. Boyen, D. Charlier, M. Crabeel, F. Van Vliet, N. Glansdorff, C. Squires, and C. L. Squires.
J Bacteriol. 1975;123(3):898-904.
Accumulation of arginine precursors in Escherichia coli: effects on growth, enzyme repression, and application to the forward selection of arginine auxotrophs.
Crabeel M, Charlier D, Cunin R, Boyen A, Glansdorff N, Pierard A. ( 1099083 )
Gene. 1979;5(3):207-31.
Cloning and endonuclease restriction analysis of argF and of the control region of the argECBH bipolar operon in Escherichia coli.
Crabeel M, Charlier D, Cunin R, Glansdorff N. ( 381103 )

Sequences
Amino acid
FASTA format
0001 MLNTLIVGAS GYAGAELVTY VNRHPHMNIT ALTVSAQSND AGKLISDLHP QLKGIVDLPL QPMSDISEFS 
0071 PGVDVVFLAT AHEVSHDLAP QFLEAGCVVF DLSGAFRVND ATFYEKYYGF THQYPELLEQ AAYGLAEWCG 
0141 NKLKEANLIA VPGCYPTAAQ LALKPLIDAD LLDLNQWPVI NATSGVSGAG RKAAISNSFC EVSLQPYGVF 
0211 THRHQPEIAT HLGADVIFTP HLGNFPRGIL ETITCRLKSG VTQAQVAQVL QQAYAHKPLV RLYDKGVPAL 
0281 KNVVGLPFCD IGFAVQGEHL IIVATEDNLL KGAAAQAVQC ANIRFGYAET QSLI

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             TAAAAATACA CTAACGTTGA GCGTAATAAA 
-070 ACCCACCAGC CGTAAGGTGA ATGTTTTACG TTTAACCTGG CAACCAGACA TAAGAAGGTG AATAGCCCCG 
0001 atgttgaata cgctgattgt gggtgccagc ggctacgctg gcgcagagct agtgacctat gtaaatcgcc 
0071 atccgcatat gaacataacc gctttgactg tttcagcgca aagcaatgat gcgggaaagt taatctccga 
0141 tttgcatccg cagctaaaag gcatcgttga tctgccgttg cagccgatgt cggatatcag cgagtttagc 
0211 ccaggggtgg acgtagtgtt tctcgccacc gcccatgaag ttagccacga tttagcgccg cagtttcttg 
0281 aagcgggctg cgtggtgttc gacctttccg gcgcgtttcg tgttaacgac gccaccttct atgaaaaata 
0351 ttacggcttt acccatcaat acccggaact gttggaacag gcagcctacg gtctggcgga gtggtgcggt 
0421 aataaattaa aagaagcgaa tttgattgcg gtgccgggct gttatccgac ggcggcacag ctggcgctga 
0491 aaccgttgat tgatgccgat cttcttgacc tcaatcagtg gccggtgatc aacgccacca gcggcgtgag 
0561 cggtgcaggg cgtaaagcgg ccatttcaaa cagcttttgt gaagttagcc tgcaaccgta tggcgtcttt 
0631 actcatcgcc atcaaccaga gatcgccaca cacctcggtg ctgacgttat cttcacccca catctgggca 
0701 atttcccgcg cggcattctc gaaaccatta cctgccgcct gaaatcgggt gtgacccagg cgcaagtcgc 
0771 gcaagtgtta cagcaggcgt atgcccataa accgctggtg cggctgtatg acaaaggcgt tccggcgctg 
0841 aaaaatgtcg ttgggctgcc attttgcgat atcgggtttg ccgttcaggg cgagcatctg attattgtgg 
0911 cgaccgaaga caacttactg aaaggcgcgg cggcacaagc ggtacagtgc gccaatattc gtttcggcta 
0981 tgcggaaacg cagtctctta tttaaGGGTG CAATGATGAA TCCATTAATT ATCAAACTGG GCGGCGTACT 
1051 GCTGGATAGT GAAGAGGCGC TGGAACGTCT GTTTAGCGCA CTGGTGAATT ATCGT