|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR38
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
proC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
proC
Search strains by all related name:
proC b0386 ECK0381 JW0377 pro pro-2 pro-3 Pro2
|
General information (Go to Linear View: )
|
|
Gene Name
|
proC
|
|
Alternative name
|
b0386,ECK0381,JW0377,pro,pro-2,pro-3,Pro2
|
|
Location, Length
|
404,059 - 404,868
(
-
)
;
8.71
min
;
810
(bp) ,
269
(aa)
|
|
Product
|
pyrroline-5-carboxylate reductase, NAD(P)-binding
|
|
Operon Name
|
proC
|
|
Note
|
pyrroline-5-carboxylate reductase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006561 - proline biosynthetic process
|
|
Function
|
enzyme; Amino acid biosynthesis: Proline
|
|
Gene Ontology
|
GO:0003824;
catalytic activity ( proC )
GO:0004735;
pyrroline-5-carboxylate reductase activity ( proC )
GO:0005488;
binding ( proC )
GO:0005737;
cytoplasm ( proC )
GO:0006118;
electron transport ( proC )
GO:0006561;
proline biosynthetic process ( proC )
GO:0008152;
metabolic process ( proC )
GO:0008652;
amino acid biosynthetic process ( proC )
GO:0016491;
oxidoreductase activity ( proC )
|
|
PID
|
1786585
|
EC number
(KEGG Pathway)
|
1.5.1.2
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
proC
(
EG10769
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
PROC_ECOLI
(
P00373
)
|
|
- Protein name
|
Pyrroline-5-carboxylate reductase
|
|
- Synonyms
|
EC 1.5.1.2, P5CR, P5C reductase
|
|
- Gene name
|
Name=proC; OrderedLocusNames=b0386, SF0322, S0330;
|
|
MMBR References
|
Nucleic Acids Res. 1982;10:7701-7714
Escherichia coli delta-1-pyrroline-5-carboxylate reductase: gene sequence, protein overproduction and purification.
Deutch, A. H., C. J. Smith, K. E. Rushlow, and P. J. Kretschmer.
|
Gene. 1983;22(2-3):281-7.
A partial restriction map of the proA-purE region of the Escherichia coli K12 chromosome.
Hadley RG, Hu M, Timmons M, Yun K, Deonier RC.
(
6307829
)
|
J Gen Microbiol. 1979;113(1):155-64.
Isolation of haemin-requiring mutants of Escherichia coli K12.
McConville ML, Charles HP.
(
387909
)
|
Mol Gen Genet. 1982;185(3):510-2.
Recombinant plasmids with genes for the biosynthesis of alkaline phosphatase of Escherichia coli.
Boidol W, Simonis M, Topert M, Siewert G.
(
6285149
)
|
J Bacteriol. 1986;165(1):226-32.
Genetic and molecular analysis of aroL, the gene for shikimate kinase II in Escherichia coli K-12.
DeFeyter RC, Pittard J.
(
3001024
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MEKKIGFIGC GNMGKAILGG LIASGQVLPG QIWVYTPSPD KVAALHDQFG INAAESAQEV AQIADIIFAA
0071 VKPGIMIKVL SEITSSLNKD SLVVSIAAGV TLDQLARALG HDRKIIRAMP NTPALVNAGM TSVTPNALVT
0141 PEDTADVLNI FRCFGEAEVI AEPMIHPVVG VSGSSPAYVF MFIEAMADAA VLGGMPRAQA YKFAAQAVMG
0211 SAKMVLETGE HPGALKDMVC SPGGTTIEAV RVLEEKGFRA AVIEAMTKCM EKSEKLSKS
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 taatcctcta ttgtgtcgcg cttttgcctt
-070 ccggcatagt tctgtttatg cttctgccag cgattatcaa aacaatgaat ttcacggcag gagtgaggca
0001 atggaaaaga aaatcggttt tattggctgc ggcaatatgg gaaaagccat tctcggcggt ctgattgcca
0071 gcggtcaggt gcttccaggg caaatctggg tatacacccc ctccccggat aaagtcgccg ccctgcatga
0141 ccagttcggc atcaacgccg cagaatcggc gcaagaagtg gcgcaaatcg ccgacatcat ttttgctgcc
0211 gttaaacctg gcatcatgat taaagtgctt agcgaaatca cctccagcct gaataaagac tctctggtcg
0281 tttctattgc tgcaggtgtc acgctcgacc agcttgcccg cgcgctgggc catgaccgga aaattatccg
0351 cgccatgccg aacactcccg cactggttaa tgccgggatg acctccgtaa cgccaaacgc gctggtaacc
0421 ccagaagata ccgctgatgt gctgaatatt ttccgctgct ttggcgaagc ggaagtaatt gctgagccga
0491 tgatccaccc ggtggtcggt gtgagcggtt cttcgccagc ctacgtattt atgtttatcg aagcgatggc
0561 cgacgccgcc gtgctgggcg ggatgccacg cgcccaggcg tataaatttg ccgctcaggc ggtaatgggt
0631 tccgcaaaaa tggtgctgga aacgggagaa catccggggg cactgaaaga tatggtctgc tcaccgggag
0701 gcaccaccat tgaagcggta cgcgtactgg aagagaaagg cttccgtgct gcagtgatcg aagcgatgac
0771 gaagtgtatg gaaaaatcag aaaaactcag caaatcctga tgactttcgc cggacgtcag gccgccactt
0841 cggtgcggtt acgtccggct ttctttgctt tgtaaagcgc caaatctgcc gatttcaacc actcacgata
|
