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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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J Bacteriol. 1999;181(6):1912-9.
The cyclic AMP receptor protein is dependent on GcvA for regulation of the gcv operon.
Wonderling LD, Stauffer GV.
(
10074087
)
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Deletion
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OCR03
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
cyaA
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Related strains
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Strains Search
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Search strains by gene name:
cyaA
Search strains by all related name:
cyaA b3806 cya ECK3800 JW3778 o848
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General information (Go to Linear View: )
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Gene Name
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cyaA
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Alternative name
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b3806,cya,ECK3800,JW3778,o848
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Location, Length
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3,989,176 - 3,991,722
(
+
)
;
85.98
min
;
2547
(bp) ,
848
(aa)
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Product
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adenylate cyclase
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Operon Name
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cyaA
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Note
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GO_component: GO:0005737 - cytoplasm
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Function
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enzyme; Global regulatory functions
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Gene Ontology
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GO:0004016
;
adenylate cyclase activity ( cyaA )
GO:0005737
;
cytoplasm ( cyaA )
GO:0006171
;
cAMP biosynthetic process ( cyaA )
GO:0016829
;
lyase activity ( cyaA )
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PID
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1790238
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EC number
(KEGG Pathway)
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4.6.1.1
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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CYAA_ECOLI
(
P00936
)
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- Protein name
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Adenylate cyclase
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- Synonyms
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EC 4.6.1.1, ATP pyrophosphate-lyase, Adenylyl cyclase
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- Gene name
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Name=cyaA; Synonyms=cya; OrderedLocusNames=b3806;
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MMBR References
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Genet Res. 1990;55(1):1-6.
A cya deletion mutant of Escherichia coli develops thermotolerance but does not exhibit a heat-shock response.
Delaney JM.
(
2180785
)
|
J Bacteriol. 1982;151(3):1346-57.
Regulation of adenylate cyclase synthesis in Escherichia coli: studies with cya-lac operon and protein fusion strains.
Bankaitis VA, Bassford PJ Jr.
(
6286596
)
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Proc Natl Acad Sci U S A. 1997;94:12914-12919
cAMP receptor protein-cAMP plays a crucial role in glucose-lactose diauxie by activating the major glucose transporter gene in Escherichia coli.
Kimata, K., H. Takahashi, T. Inada, P. Postma, and H. Aiba.
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Nucleic Acids Res. 1988;16:2601-2612
Randomly picked cosmid clones overlap the pyrB and oriC gap in the physical map of the E. coli chromosome.
Knott, V., D. J. G. Rees, Z. Cheng, and G. G. Brownlee.
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Gene. 1984;28(2):133-46.
Analysis of the cya locus of Escherichia coli.
Koop AH, Hartley M, Bourgeois S.
(
6329917
)
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J Bacteriol. 1976;125(2):545-55.
Properties of adenyl cyclase and cyclic adenosine 3',5'-monophosphate receptor protein-deficient mutants of Escherichia coli.
Kumar S.
(
173710
)
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J Biol Chem. 1985;260:3063-3070
Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein.
Aiba, H.
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Nucleic Acids Res. 1984;12:9427-9440
The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli.
Aiba, H., K. Mori, M. Tanaka, T. Ooi, A. M. Roy, and A. Danchin.
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Nucleic Acids Res. 1983;11:3451-3465
Cloning and promoter analysis of the Escherichia coli adenylate cyclase gene.
Aiba, H., M. Kawamukai, and A. Ishihama.
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Mutat Res. 1992;282(4):247-52.
UV resistance of E. coli K-12 deficient in cAMP/CRP regulation.
Puyo MF, Calsou P, Salles B.
(
1379686
)
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Biochimie. 1981;63(8-9):719-22.
Restriction map of the cya region of the Escherichia coli K12 chromosome.
Roy A, Danchin A.
(
6272879
)
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Mol Gen Genet. 1982;188(3):465-71.
The cya locus of Escherichia coli K12: organization and gene products.
Roy A, Danchin A.
(
6298576
)
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EMBO J. 1983;2(5):791-7.
Regulation of adenylate cyclase synthesis in Escherichia coli: nucleotide sequence of the control region.
Roy A, Haziza C, Danchin A.
(
6357786
)
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Nucleic Acids Res. 1986;14:6215-6226
Nucleotide sequence of the hemC locus encoding porphobilinogen deaminase of Escherichia coli K12.
Thomas, S. D., and P. M. Jordan.
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J Bacteriol. 1973;116(2):582-7.
Genetic characterization of mutations which affect catabolite-sensitive operons in Escherichia coli, including deletions of the gene for adenyl cyclase.
Brickman E, Soll L, Beckwith JR.
(
4583241
)
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J Mol Biol. 1988;200(3):427-38.
Generation of a detailed physical and genetic map of the ilv-metE-udp region of the Escherichia coli chromosome.
Aldea M, Maples VF, Kushner SR.
(
3294419
)
|
Mol Gen Genet. 1979;176(3):343-50.
Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K 12 toward serine: excretion of 2-ketobutyrate, a precursor of isoleucine.
Daniel J, Danchin A.
(
230407
)
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Science. 1992;257(5071):771-8.
Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.
Daniels DL, Plunkett G 3rd, Burland VD, Blattner FR.
(
1379743
)
|
| Sequences |
Amino acid
FASTA format
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0001 MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP GYLDGNVPKG ICLYTPDETQ
0071 RHYLNELELY RGMSVQDPPK GELPITGVYT MGSTSSVGQS CSSDLDIWVC HQSWLDSEER QLLQRKCSLL
0141 ENWAASLGVE VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW NMVPCDEEEH
0211 YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL
0281 LAKDIKQRLH DGEIVSFGLD PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV
0351 LSQLVSEWGW DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR
0421 KLYAAFEALP GKVTLVNPQI SPDLSEPNLT FIYVPPGRAN RSGWYLYNRA PNIESIISHQ PLEYNRYLNK
0491 LVAWAWFNGL LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR HLAIIVNLEY
0561 DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN SWNEVRTLHF NGEQSMIEAL KTILGKMHQD
0631 AAPPDSVEVF CYSQHLRGLI RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL
0701 ENAIEFYGAI SHNKLHGLSV QVETNHVKLP AVVDGFASEG IIQFFFEETQ DENGFNIYIL DESNRVEVYH
0771 HCEGSKEELV RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVKVDGREQV IPFRTKSIGN MPPANQDHDT
0841 PLLQQYFS
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 AACGGTTACC TTTGACATAC GAAATATCCC
-070 GAATGCCGCG TGTTACCGTT GATGTTGGCG GAATCACAGT CATGACGGGT AGCAAATCAG GCGATACGTC
0001 ttgtacctct atattgagac tctgaaacag agactggatg ccataaatca attgcgtgtg gatcgcgcgc
0071 ttgctgctat ggggcctgca ttccaacagg tctacagtct actgccgaca ttgttgcact atcaccatcc
0141 gctaatgccg ggttaccttg atggtaacgt tcccaaaggc atttgccttt acacgcctga tgaaactcaa
0211 cgccactacc tgaacgagct tgaactgtat cgtggaatgt cagtacagga tccgccgaaa ggtgagcttc
0281 caattactgg tgtatacacc atgggcagca cctcgtccgt agggcaaagt tgttcctctg acctggatat
0351 ctgggtctgt catcaatcct ggctcgatag cgaagagcgc caattgctac aacgtaaatg tagcctgctg
0421 gaaaactggg ccgcctcgct gggtgtggaa gtcagcttct tcctgattga tgaaaaccgc ttccgtcata
0491 atgaaagcgg cagcctgggg ggcgaagatt gtggctccac ccagcatata ctgctgcttg acgaatttta
0561 tcgtaccgcc gtgcgtctcg ccggtaagcg tattctgtgg aatatggtgc cgtgcgacga agaagagcat
0631 tacgacgact atgtgatgac gctttacgcg cagggcgtgc tgacgccaaa tgaatggctg gatctcggtg
0701 gcttaagctc gctttctgct gaagagtact ttggtgccag cctttggcag ctctacaaga gtatcgattc
0771 cccatacaaa gcggtactga aaacactgct gctggaagcc tattcctggg aatacccgaa cccacgtctg
0841 ctggcgaaag atatcaaaca gcgtttgcac gacggcgaga ttgtatcgtt tggtctcgat ccatactgca
0911 tgatgctgga gcgtgttact gaatacctga cggcgattga agattttacc cgtctggatt tagtacgtcg
0981 ctgcttctat ttaaaagtgt gcgaaaagct cagccgtgaa cgcgcctgcg taggctggcg tcgcgcagtg
1051 ttgagccagt tagtgagcga gtggggttgg gacgaagctc gtctggcaat gctcgataac cgcgctaact
1121 ggaagattga tcaggtgcgt gaggcgcaca acgagttgct cgacgcgatg atgcagagct accgtaatct
1191 gatccgcttt gcgcgtcgca ataaccttag cgtctccgcc agtccgcagg atatcggcgt gctgacgcgt
1261 aagctgtatg ccgcgtttga agcattacca ggtaaagtga cgctggtaaa cccgcagatt tcacccgatc
1331 tctcggaacc gaatctgacc tttatttatg tgccgccggg ccgggctaac cgttcaggtt ggtatctgta
1401 taaccgcgcg ccaaatattg agtcgatcat cagccatcag ccgctggaat ataaccgtta cctgaataaa
1471 ctggtggcgt gggcatggtt taacggcctg ctgacctcgc gcacccgttt gtatattaaa ggtaacggca
1541 ttgtcgattt gcctaagttg caggagatgg tcgccgacgt gtcgcaccat ttcccgctgc gcttacctgc
1611 accgacaccg aaggcgctct acagcccgtg tgagatccgc catctggcga ttatcgttaa cctggaatat
1681 gacccgacag cggcgttccg caatcaggtg gtgcatttcg atttccgtaa gctggatgtc ttcagctttg
1751 gcgagaatca aaattgcctg gtaggtagcg ttgacctgct gtaccgcaac tcgtggaacg aagtgcgtac
1821 gctgcacttc aacggcgagc aatcgatgat cgaagccctg aaaactattc tcggcaaaat gcatcaggac
1891 gccgcaccgc cagatagcgt ggaagtcttc tgttatagcc agcatctgcg cggcttaatt cgtactcgcg
1961 tgcagcaact ggtttctgag tgtattgaat tgcgtctttc cagcacccgc caggaaaccg ggcgtttcaa
2031 ggcgctgcgc gtttctggtc aaacctgggg gttgttcttc gaacgcctga atgtatcggt acagaaactg
2101 gaaaacgcca tcgagtttta tggcgcgatt tcgcataaca aactgcacgg cctgtcagtg caggttgaaa
2171 ccaatcacgt caaattaccg gcggtggtgg acggctttgc cagcgaaggg atcatccagt tctttttcga
2241 agaaacgcaa gacgagaatg gctttaatat ctacattctc gacgaaagca accgggttga ggtatatcac
2311 cactgcgaag gcagcaaaga ggagctggta cgtgacgtca gtcgcttcta ctcgtcatcg catgaccgtt
2381 ttacctacgg ctcaagcttc atcaacttca acctgccgca gttctatcag attgtgaagg ttgatggtcg
2451 tgaacaggtg attccgttcc gcacaaaatc tatcggtaac atgccgcctg ccaatcagga tcacgatacg
2521 ccgctattac agcaatattt ttcgtgaTGA ACGTGCCGGA AAGCGAGGCT TATCCGGCAT GCAATCTTAG
2591 CGGAAACTGA CTGTTTCACC CGCCTGCTGC GTCGCCGCCT GTTCCAGCAA ATCCCAG
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