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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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OCR02-6
(D)
,
DE(ilvE-ilvC)2049
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
ilvD
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Related strains
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Strains Search
|
Search strains by gene name:
ilvD
Search strains by all related name:
ilvD b3771 ECK3763 JW5605 o605
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General information (Go to Linear View: )
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Gene Name
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ilvD
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Alternative name
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b3771,ECK3763,JW5605,o605
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Location, Length
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3,951,501 - 3,953,351
(
+
)
;
85.17
min
;
1851
(bp) ,
616
(aa)
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Product
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dihydroxyacid dehydratase
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Operon Name
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ilvLXG_1G_2MEDA
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Note
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Function
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enzyme; Amino acid biosynthesis: Isoleucine, Valine,1.5.1.18 metabolism; building blockbiosynthesis; amino acids; isoleucine/valine
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Gene Ontology
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GO:0003824
;
catalytic activity ( ilvD )
GO:0004160
;
dihydroxy-acid dehydratase activity ( ilvD )
GO:0005506
;
iron ion binding ( ilvD )
GO:0008152
;
metabolic process ( ilvD )
GO:0008652
;
amino acid biosynthetic process ( ilvD )
GO:0009082
;
branched chain family amino acid biosynthetic process ( ilvD )
GO:0009097
;
isoleucine biosynthetic process ( ilvD )
GO:0009099
;
valine biosynthetic process ( ilvD )
GO:0016829
;
lyase activity ( ilvD )
GO:0046872
;
metal ion binding ( ilvD )
GO:0051536
;
iron-sulfur cluster binding ( ilvD )
GO:0051539
;
4 iron, 4 sulfur cluster binding ( ilvD )
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PID
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48994964
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EC number
(KEGG Pathway)
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4.2.1.9
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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ILVD_ECOLI
(
P05791
)
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- Protein name
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Dihydroxy-acid dehydratase
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- Synonyms
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EC 4.2.1.9, DAD
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- Gene name
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Name=ilvD; OrderedLocusNames=b3771;
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MMBR References
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J Bacteriol. 1985;162(2):598-606.
Physical analysis of deletion mutations in the ilvGEDA operon of Escherichia coli K-12.
Driver RP, Lawther RP.
(
2985538
)
|
J Bacteriol. 1982;149(3):1071-81.
Physical and genetic localization of ilv regulatory sites in lambda ilv bacteriophages.
Gray JE, Bennett DC, Umbarger HE, Calhoun DH.
(
6277848
)
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J Bacteriol. 1992;174:4871-4877
Multiple transcripts encoded by the ilvGMEDA gene cluster of Escherichia coli K-12.
Huang, F., G. Coppola, and D. H. Calhoun.
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Nucleic Acids Res. 1987;15:2137-2155
The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12.
Lawther, R. P., R. C. Wek, J. M. Lopes, R. Pereira, B. E. Taillon, and G. W. Hatfield.
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Genetics 1979;93:309-319
Physiological characterization of polar Tn5-induced isoleucine-valine auxotrophs in Escherichia coli: evidence for an internal promoter in the ilvOGEDA operon.
Berg, C. M., K. J. Shaw, J. Vender, and M. Borucka-Mankiewicz.
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J Mol Biol. 1988;200(3):427-38.
Generation of a detailed physical and genetic map of the ilv-metE-udp region of the Escherichia coli chromosome.
Aldea M, Maples VF, Kushner SR.
(
3294419
)
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Gene. 1987;56(2-3):185-98.
The complete nucleotide sequence of the ilvGMEDA cluster of Escherichia coli K-12.
Cox JL, Cox BJ, Fidanza V, Calhoun DH.
(
3315862
)
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Science. 1992;257(5071):771-8.
Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.
Daniels DL, Plunkett G 3rd, Burland VD, Blattner FR.
(
1379743
)
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| Sequences |
Amino acid
FASTA format
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0001 MPKYRSATTT HGRNMAGARA LWRATGMTDA DFGKPIIAVV NSFTQFVPGH VHLRDLGKLV AEQIEAAGGV
0071 AKEFNTIAVD DGIAMGHGGM LYSLPSRELI ADSVEYMVNA HCADAMVCIS NCDKITPGML MASLRLNIPV
0141 IFVSGGPMEA GKTKLSDQII KLDLVDAMIQ GADPKVSDSQ SDQVERSACP TCGSCSGMFT ANSMNCLTEA
0211 LGLSQPGNGS LLATHADRKQ LFLNAGKRIV ELTKRYYEQN DESALPRNIA SKAAFENAMT LDIAMGGSTN
0281 TVLHLLAAAQ EAEIDFTMSD IDKLSRKVPQ LCKVAPSTQK YHMEDVHRAG GVIGILGELD RAGLLNRDVK
0351 NVLGLTLPQT LEQYDVMLTQ DDAVKNMFRA GPAGIRTTQA FSQDCRWDTL DDDRANGCIR SLEHAYSKDG
0421 GLAVLYGNFA ENGCIVKTAG VDDSILKFTG PAKVYESQDD AVEAILGGKV VAGDVVVIRY EGPKGGPGMQ
0491 EMLYPTSFLK SMGLGKACAL ITDGRFSGGT SGLSIGHVSP EAASGGSIGL IEDGDLIAID IPNRGIQLQV
0561 SDAELAARRE AQDARGDKAW TPKNRERQVS FALRAYASLA TSADKGAVRD KSKLGG
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 GATAAATGGG GCTGGTTAGA TCAAGTTAAT
-070 CAATAAATAC AAAAAATGGG ACGGCACGCA CCGTCCCATT TACGAGACAG ACACTGGGAG TAAATAAAGT
0001 atgcctaagt accgttccgc caccaccact catggtcgta atatggcggg tgctcgtgcg ctgtggcgcg
0071 ccaccggaat gaccgacgcc gatttcggta agccgattat cgcggttgtg aactcgttca cccaatttgt
0141 accgggtcac gtccatctgc gcgatctcgg taaactggtc gccgaacaaa ttgaagcggc tggcggcgtt
0211 gccaaagagt tcaacaccat tgcggtggat gatgggattg ccatgggcca cggggggatg ctttattcac
0281 tgccatctcg cgaactgatc gctgattccg ttgagtatat ggtcaacgcc cactgcgccg acgccatggt
0351 ctgcatctct aactgcgaca aaatcacccc ggggatgctg atggcttccc tgcgcctgaa tattccggtg
0421 atctttgttt ccggcggccc gatggaggcc gggaaaacca aactttccga tcagatcatc aagctcgatc
0491 tggttgatgc gatgatccag ggcgcagacc cgaaagtatc tgactcccag agcgatcagg ttgaacgttc
0561 cgcgtgtccg acctgcggtt cctgctccgg gatgtttacc gctaactcaa tgaactgcct gaccgaagcg
0631 ctgggcctgt cgcagccggg caacggctcg ctgctggcaa cccacgccga ccgtaagcag ctgttcctta
0701 atgctggtaa acgcattgtt gaattgacca aacgttatta cgagcaaaac gacgaaagtg cactgccgcg
0771 taatatcgcc agtaaggcgg cgtttgaaaa cgccatgacg ctggatatcg cgatgggtgg atcgactaac
0841 accgtacttc acctgctggc ggcggcgcag gaagcggaaa tcgacttcac catgagtgat atcgataagc
0911 tttcccgcaa ggttccacag ctgtgtaaag ttgcgccgag cacccagaaa taccatatgg aagatgttca
0981 ccgtgctggt ggtgttatcg gtattctcgg cgaactggat cgcgcggggt tactgaaccg tgatgtgaaa
1051 aacgtacttg gcctgacgtt gccgcaaacg ctggaacaat acgacgttat gctgacccag gatgacgcgg
1121 taaaaaatat gttccgcgca ggtcctgcag gcattcgtac cacacaggca ttctcgcaag attgccgttg
1191 ggatacgctg gacgacgatc gcgccaatgg ctgtatccgc tcgctggaac acgcctacag caaagacggc
1261 ggcctggcgg tgctctacgg taactttgcg gaaaacggct gcatcgtgaa aacggcaggc gtcgatgaca
1331 gcatcctcaa attcaccggc ccggcgaaag tgtacgaaag ccaggacgat gcggtagaag cgattctcgg
1401 cggtaaagtt gtcgccggag atgtggtagt aattcgctat gaaggcccga aaggcggtcc ggggatgcag
1471 gaaatgctct acccaaccag cttcctgaaa tcaatgggtc tcggcaaagc ctgtgcgctg atcaccgacg
1541 gtcgtttctc tggtggcacc tctggtcttt ccatcggcca cgtctcaccg gaagcggcaa gcggcggcag
1611 cattggcctg attgaagatg gtgacctgat cgctatcgac atcccgaacc gtggcattca gttacaggta
1681 agcgatgccg aactggcggc gcgtcgtgaa gcgcaggacg ctcgaggtga caaagcctgg acgccgaaaa
1751 atcgtgaacg tcaggtctcc tttgccctgc gtgcttatgc cagcctggca accagcgccg acaaaggcgc
1821 ggtgcgcgat aaatcgaaac tggggggtta aTAATGGCTG ACTCGCAACC CCTGTCCGGT GCTCCGGAAG
1891 GTGCCGAATA TTTAAGAGCA GTGCTGCGCG CGCCGGTTTA CGAGGCGGCG CAGGTTACGC C
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