|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCL09
(D)
,
OCL09-2
(D)
,
OCL09-9
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
mtlD
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
mtlD
Search strains by all related name:
mtlD b3600 ECK3589 JW3574
|
General information (Go to Linear View: )
|
|
Gene Name
|
mtlD
|
|
Alternative name
|
b3600,ECK3589,JW3574
|
|
Location, Length
|
3,772,447 - 3,773,595
(
+
)
;
81.31
min
;
1149
(bp) ,
382
(aa)
|
|
Product
|
mannitol-1-phosphate dehydrogenase, NAD-dependent
|
|
Operon Name
|
mtlADR
|
|
Note
|
mannitol-1-phosphate dehydrogenase; GO_process: GO:0016052 - carbohydrate catabolic process
|
|
Function
|
enzyme; Degradation of small molecules: Carbon compounds
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( mtlD )
GO:0005488
;
binding ( mtlD )
GO:0005515
;
protein binding ( mtlD )
GO:0008152
;
metabolic process ( mtlD )
GO:0008926
;
mannitol-1-phosphate 5-dehydrogenase activity ( mtlD )
GO:0016491
;
oxidoreductase activity ( mtlD )
GO:0050662
;
coenzyme binding ( mtlD )
|
|
PID
|
1790028
|
EC number
(KEGG Pathway)
|
1.1.1.17
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
mtlD
(
EG10616
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
MTLD_ECOLI
(
P09424
)
|
|
- Protein name
|
Mannitol-1-phosphate 5-dehydrogenase
|
|
- Synonyms
|
EC 1.1.1.17
|
|
- Gene name
|
Name=mtlD; OrderedLocusNames=b3600;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
mtlD
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Mannitol Dehydrogenase In Complex With Nad
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Mannitol-1-phosphate 5-dehydrogenase
|
|
PSI-BLAST
|
Mannitol-1-phosphate 5-dehydrogenase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
mannitol-1-phosphate 5-dehydrogenase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
MANNITOL_DHGENASE
|
|
MMBR References
|
Mol Microbiol. 1990;4(11):2003-6.
Corrected sequence of the mannitol (mtl) operon in Escherichia coli.
Jiang W, Wu LF, Tomich J, Saier MH Jr, Niehaus WG.
(
1964486
)
|
J Bacteriol. 1981;147(2):612-21.
Structural studies of lambda transducing bacteriophage carrying bacterial deoxyribonucleic acid from the metBJLF region of the Escherichia coli chromosome.
Krueger JH, Johnson JR, Greene RC, Dresser M.
(
6267016
)
|
Mol Microbiol. 1988;2(3):405-12.
Nucleotide sequence of the mannitol (mtl) operon in Escherichia coli.
Davis T, Yamada M, Elgort M, Saier MH Jr.
(
3135464
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKALHFGAGN IGRGFIGKLL ADAGIQLTFA DVNQVVLDAL NARHSYQVHV VGETEQVDTV SGVNAVSSIG
0071 DDVVDLIAQV DLVTTAVGPV VLERIAPAIA KGQVKRKEQG NESPLNIIAC ENMVRGTTQL KGHVMNALPE
0141 DAKAWVEEHV GFVDSAVDRI VPPSASATND PLEVTVETFS EWIVDKTQFK GALPNIPGME LTDNLMAFVE
0211 RKLFTLNTGH AITAYLGKLA GHQTIRDAIL DEKIRAVVKG AMEESGAVLI KRYGFDADKH AAYIQKILGR
0281 FENPYLKDDV ERVGRQPLRK LSAGDRLIKP LLGTLEYGLP HKNLIEGIAA AMHFRSEDDP QAQELAALIA
0351 DKGPQAALAQ ISGLDANSEV VSEAVTAYKA MQ
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CCGCATCCGG CGCTGCCCCT CTCCTCACGG
-070 AGAGGGTTTG GGTGAGGGAA AAGCCTCACC CCAGCCCTCT CGGGTAAAAA CATTGATGAA GGTTAATACT
0001 atgaaagcat tacattttgg cgcaggtaat atcggtcgtg gctttatcgg taaactgctg gcagacgcgg
0071 gtatccaact gacgtttgcc gatgtcaatc aggtggtact tgatgccctg aatgcccgtc atagctatca
0141 ggtacatgtg gttggtgaaa ccgagcaggt agataccgtt tccggcgtca atgctgtcag cagcattggt
0211 gatgatgtcg ttgatctgat tgctcaggtt gatttagtca ctaccgccgt tggcccggtt gtgctggaac
0281 gtattgctcc ggcaatcgcc aaagggcagg tgaaacgtaa agaacaaggt aatgaatccc cgctgaacat
0351 catcgcctgt gaaaacatgg tacgcggtac cacgcagctg aaaggccatg tgatgaacgc cctgccggaa
0421 gacgccaaag cgtgggtaga agaacacgtt ggctttgtcg attccgccgt tgaccgcatc gtaccgcctt
0491 cggcttcggc aactaacgat ccgctggaag tgacggtaga aaccttcagc gaatggattg tcgataaaac
0561 gcagttcaaa ggcgcactgc cgaacatccc aggcatggag ttaaccgaca acctgatggc atttgtcgaa
0631 cgtaaactct tcaccctgaa cacgggtcat gctataaccg cgtacctcgg aaaactggcc ggtcatcaga
0701 ccattcgtga cgcgattctc gacgagaaaa tccgcgcggt ggtaaaaggt gcgatggaag aaagtggtgc
0771 agtattgatc aagcgctacg gctttgacgc tgacaagcat gcggcgtaca tccagaaaat tctcggccgt
0841 tttgagaacc cgtatctgaa agatgatgta gagcgcgtag gccgtcagcc actgcgtaaa ctgagtgctg
0911 gcgaccgtct gatcaagcca ctgctcggta cgctggaata tggtctgcca cataaaaacc tgattgaagg
0981 tattgccgct gcaatgcact tccgcagtga agatgatccg caggctcagg aactggcagc actgatcgct
1051 gacaaaggtc cgcaggcggc gctggcacag atttccggtc ttgatgccaa cagcgaggtt gtatccgagg
1121 cggtaaccgc ttataaagca atgcaataaT GGTGGACCAG GCGCAGGACA CCCTGCGCCC GAATAACAGA
1191 TTGTCAGATA TGCAGGCAAC AATGGAACAA ACCCAGGCCT TTGAAAACCG TGTGCTTGA
|
