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PEC Original Annotations
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|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
9-1
(LD)
,
OCR36,37-6 (LD 9C::Ap)
(D)
,
OCR37
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
mhpE
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
mhpE
Search strains by all related name:
mhpE b0352 ECK0349 JW0343 mhpF o337
|
General information (Go to Linear View: )
|
|
Gene Name
|
mhpE
|
|
Alternative name
|
b0352,ECK0349,JW0343,mhpF,o337
|
|
Location, Length
|
373,092 - 374,105
(
+
)
;
8.04
min
;
1014
(bp) ,
337
(aa)
|
|
Product
|
4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I
|
|
Operon Name
|
mhpABCDFE
|
|
Note
|
4-hydroxy-2-ketovalerate aldolase; GO_process: GO:0019395 - fatty acid oxidation
|
|
Function
|
enzyme; Degradation of small molecules: Carbon compounds
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( mhpE )
GO:0003824
;
catalytic activity ( mhpF )
GO:0005488
;
binding ( mhpF )
GO:0005737
;
cytoplasm ( mhpF )
GO:0006520
;
amino acid metabolic process ( mhpF )
GO:0008152
;
metabolic process ( mhpE )
GO:0008152
;
metabolic process ( mhpF )
GO:0008774
;
acetaldehyde dehydrogenase (acetylating) activity ( mhpF )
GO:0016491
;
oxidoreductase activity ( mhpF )
GO:0016620
;
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ( mhpF )
GO:0016829
;
lyase activity ( mhpE )
GO:0016833
;
oxo-acid-lyase activity ( mhpE )
GO:0019439
;
aromatic compound catabolic process ( mhpE )
GO:0019439
;
aromatic compound catabolic process ( mhpF )
GO:0051287
;
NAD binding ( mhpF )
|
|
PID
|
1786548
|
EC number
(KEGG Pathway)
|
4.1.3.-
|
|
SWISS-PROT
(
Show details
[
3
more]
)
|
Entry name(Acc.no)
|
MHPE_ECOLI
(
P51020
;
P77787
)
|
|
- Protein name
|
4-hydroxy-2-oxovalerate aldolase
|
|
- Synonyms
|
EC 4.1.3.-, HOA
|
|
- Gene name
|
Name=mhpE; Synonyms=mhpF; OrderedLocusNames=b0352;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
mhpF
(
homologous genes of other bacterias
)
mhpE
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of A Bifunctional Aldolase-Dehydrogenase : Sequestering A Reactive And Volatile Intermediate
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
4-hydroxy-2-oxovalerate aldolase
|
|
PSI-BLAST
|
2-isopropylmalate synthase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
4-hydroxy-2-ketovalerate aldolase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
|
|
MMBR References
|
J Bacteriol. 1997;179:2573-2581
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
Ferrandez, A., J. L. Garcia, and E. Diaz.
|
| Sequences |
Amino acid
FASTA format
|
0001 MNGKKLYISD VTLRDGMHAI RHQYSLENVR QIAKALDDAR VDSIEVAHGD GLQGSSFNYG FGAHSDLEWI
0071 EAAADVVKHA KIATLLLPGI GTIHDLKNAW QAGARVVRVA THCTEADVSA QHIQYARELG MDTVGFLMMS
0141 HMTTPENLAK QAKLMEGYGA TCIYVVDSGG AMNMSDIRDR FRALKAELKP ETQTGMHAHH NLSLGVANSI
0211 AAVEEGCDRI DASLAGMGAG AGNAPLEVFI AAADKLGWQH GTDLYALMDA ADDLVRPLQD RPVRVDRETL
0281 ALGYAGVYSS FLRHCETAAA RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLRNNK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TGCCTGCCTA TGCGGGCAAC CTCGACATTA
-070 TGACTTCCAG TGCGCTGGCG ACAGCGGAAA AAATGGCCCA GTCACTGGCG CGCAAGGCAG GAGAAGCGGC
0001 atgaacggta aaaaacttta tatctcggac gtcacattgc gtgacggtat gcacgccatt cgtcatcagt
0071 attcgctgga aaacgttcgc cagattgcca aagcactgga cgatgcccgc gtggattcga ttgaagtggc
0141 ccacggcgac ggtttgcaag gttccagctt taactatggt ttcggcgcac atagcgacct tgaatggatt
0211 gaagcggcgg cggatgtggt gaagcacgcc aaaatcgcga cgttgttgct gccaggaatc ggcactattc
0281 acgatctgaa aaatgcctgg caggctggcg cgcgggtggt tcgtgtggca acgcactgta ccgaagctga
0351 tgtttccgcc cagcatattc agtatgcccg cgagctcgga atggacaccg ttggttttct gatgatgagc
0421 catatgacca cgccggagaa tctcgccaag caggcaaagc tgatggaagg ctacggtgcg acctgtattt
0491 atgtggtgga ttctggcggt gcgatgaaca tgagcgatat ccgtgaccgt ttccgcgccc tgaaagcaga
0561 gctgaaacca gaaacgcaaa ctggcatgca cgctcaccat aacctgagtc ttggcgtggc gaactctatc
0631 gcggcggtgg aagagggctg cgaccgaatc gacgccagcc tcgcgggaat gggcgcgggc gcaggtaacg
0701 caccgctgga agtgtttatt gccgccgcgg ataaactggg ctggcagcat gggaccgatc tctatgcgtt
0771 aatggatgcc gccgacgacc tggtgcgtcc gttgcaggat cgaccggtac gagtcgatcg cgaaacgctg
0841 gcgctgggat acgctggtgt ttactcgagc ttcctgcgtc actgtgaaac ggcggcggcg cgttatggct
0911 taagtgcggt ggatattctc gttgagctgg gcaaacgccg gatggttggc ggccaggagg atatgatcgt
0981 tgacgtggcg ctggatctgc gcaacaacaa ataaTGATGA CTGCCGAGAA CGTGCATTTT GTATGCCCAT
1051 CCCAGCACGA CTGCCGGATG CGGCGTGAAC GCCTTATCCG GCCTACGGAT GGCGTGAGAA TTTG
|
