MG1655
W3110
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Gene Report : mhpA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion 9-1 (LD)  ,  OCR36,37-6 (LD 9C::Ap) (D)  ,  OCR37 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  mhpA
Related strains
     Strains Search Search strains by gene name:  mhpA   Search strains by all related name:  mhpA b0347 ECK0344 JW0338 o554

General information  (Go to Linear View:)
 Gene Name mhpA  
 Alternative name b0347,ECK0344,JW0338,o554  
 Location, Length 367,835 - 369,499 (  +  ) ;   7.93 min ; 1665 (bp) ,   554 (aa) Go to Linear View
 Product 3-(3-hydroxyphenyl)propionate hydroxylase  
 Operon Name mhpABCDFE  
 Note GO_process: GO:0019395 - fatty acid oxidation  
 Function enzyme; Degradation of small molecules: Carbon compounds  
 Gene Ontology GO:0004497 ; monooxygenase activity ( mhpA )
GO:0006118 ; electron transport ( mhpA )
GO:0006725 ; aromatic compound metabolic process ( mhpA )
GO:0008152 ; metabolic process ( mhpA )
GO:0016491 ; oxidoreductase activity ( mhpA )
GO:0019439 ; aromatic compound catabolic process ( mhpA )
GO:0050660 ; FAD binding ( mhpA )
 PID 1786543  
 EC number
  (KEGG Pathway)   		1.14.13.-  
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) MHPA_ECOLI ( P77397 ; P71203; P77047 )
    -  Protein name 3-(3-hydroxy-phenyl)propionate hydroxylase  
    -  Synonyms EC 1.14.13.-  
    -  Gene name Name=mhpA; OrderedLocusNames=b0347;  

 Linear View (Whole Mode)
View Location
   355.0  –  380.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP mhpA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of 3-Hydroxybenzoate Hydroxylase From Comamonas Testosteroni, In Complex With The Substrate  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST 3-  
         PSI-BLAST tRNA uridine 5-carboxymethylaminomethyl modification enzyme gidA
    nr     (database updated : 2007.02.20 )
         BLAST 3-(3-hydroxyphenyl)propionate hydroxylase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG0654HC 
    EcoCyc mhpA 

MMBR References
J Bacteriol. 1997;179:2573-2581
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
Ferrandez, A., J. L. Garcia, and E. Diaz.
Ph.D. thesis. University of Minnesota, Minneapolis-St. Paul. 1983
The degradation of 3-phenylpropionic acid by Escherichia coli.
Burlingame, R. P.
J Bacteriol. 1986;168(1):55-64.
Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation.
Burlingame RP, Wyman L, Chapman PJ. ( 3531186 )

Sequences
Amino acid
FASTA format 
0001 MAIQHPDIQP AVNHSVQVAI AGAGPVGLMM ANYLGQMGID VLVVEKLDKL IDYPRAIGID DEALRTMQSV 
0071 GLVDDVLPHT TPWHAMRFLT PKGRCFADIQ PMTDEFGWPR RNAFIQPQVD AVMLEGVSRF PNVRCLFSRE 
0141 LEAFSQQDDE VTLHLKTAEG QREIVKAQWL VACDGGASFV RRTLNVPFEG KTAPNQWIVV DIANDPLSTP 
0211 HIYLCCDPVR PYVSAALPHA VRRFEFMVMP GETEEQLREP QNMRKLLSKV LPNPDNVELI RQRVYTHNAR 
0281 LAQRFRIDRV LLAGDAAHIM PVWQGQGYNS GMRDAFNLAW KLALVIQGKA RDALLDTYQQ ERRDHAKAMI 
0351 DLSVTAGNVL APPKRWQGTL RDGVSWLLNY LPPVKRYFLE MRFKPMPQYY GGALMREGEA KHSPVGKMFI 
0421 QPKVTLENGD VTLLDNAIGA NFAVIGWGCN PLWGMSDEQI QQWRALGTRF IQVVPEVQIH TAQDNHDGVL 
0491 RVGDTQGRLR SWFAQHNASL VVMRPDRFVA ATAIPQTLGK TLNKLASVMT LTRPDADVSV EKVA
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             ACTGAGCGCA CAATAAAAAA TCATTTACAT 
-070 GTTTTTAACA AAATAAGTTG CGCTGTACTG TGCGCGCAAC GACATTTTGT CCGAGTCGTG AGGTACTGAA 
0001 atggcaatac aacaccctga catccagcct gctgttaacc atagcgttca ggtggcgatc gctggtgccg 
0071 gcccggttgg gctgatgatg gcgaactatc tcggccagat gggcattgac gtgctggtgg tggagaaact 
0141 cgataagttg atcgactacc cgcgtgcgat tggtattgat gacgaggcgc tgcgcaccat gcagtcggtc 
0211 ggcctggtcg atgatgttct gccgcacact acgccgtggc acgcgatgcg ttttctcacc ccgaaaggcc 
0281 gctgttttgc tgatattcag ccaatgaccg atgaatttgg ctggccgcgc cgtaacgcct ttattcagcc 
0351 gcaggtcgat gcggtgatgc tggaaggggt gtcgcgtttt ccgaatgtgc gctgcttgtt ttcccgcgag 
0421 ctggaggcct tcagtcagca agatgacgaa gtgaccttgc acctgaaaac ggcagaaggg cagcgggaaa 
0491 tagtcaaagc ccagtggctg gtagcctgtg acggtggagc aagttttgtc cgtcgcactc tgaatgtgcc 
0561 gtttgaaggt aaaactgcgc caaatcagtg gattgtggta gatatcgcca acgatccgtt aagtacgccg 
0631 catatctatt tgtgttgcga tccggtgcgc ccgtatgttt ctgccgcgct gcctcatgcg gtacgtcgct 
0701 ttgaatttat ggtgatgccg ggagaaaccg aagagcagct gcgtgagccg caaaatatgc gcaagctgtt 
0771 aagcaaagtg ctgcctaatc cggacaatgt tgaattgatt cgccagcgtg tctacaccca caacgcgcga 
0841 ctggcgcaac gtttccgtat tgatcgcgta ctgctggcgg gcgatgccgc gcacatcatg ccggtatggc 
0911 aggggcaggg ctataacagt ggtatgcgcg acgcctttaa cctcgcatgg aaactggcgt tggttatcca 
0981 ggggaaagcc cgcgatgcgc tgctcgatac ctatcaacaa gaacgtcgcg atcacgccaa agcgatgatt 
1051 gacctgtccg tgacggcggg caacgtgctg gctccgccga aacgctggca gggtacgtta cgtgacggcg 
1121 tttcctggct gttgaattat ctgccgccag taaaacgcta cttcctcgaa atgcgcttca agccgatgcc 
1191 gcaatattac ggcggtgcgc tgatgcgtga gggcgaagcg aagcactctc cggtcggcaa gatgtttatt 
1261 cagccgaaag tcacgctgga aaacggcgac gtgacgctgc tcgataacgc gatcggcgcg aacttcgcgg 
1331 taattggctg gggatgcaat ccactgtggg ggatgagcga cgagcaaatc cagcagtggc gcgcgttggg 
1401 cacacgcttc attcaggtgg tgccggaagt gcaaattcat accgcacagg ataaccacga cggcgtacta 
1471 cgcgtgggcg atacgcaagg tcgcctgcgt agctggttcg cgcaacacaa tgcttcgctg gtggtgatgc 
1541 gcccggatcg ctttgttgcc gccaccgcca ttccgcaaac cctgggcaag accctgaata aactggcgtc 
1611 ggtgatgacg ctgacccgcc ctgatgccga cgtttctgtc gaaaaggtag cctgaTATGC ACGCTTATCT 
1681 TCACTGTCTT TCCCACTCGC CGCTGGTGGG GTATGTCGAC CCGGCGCAAG AGGTGCTCGA TGAGGTCAAT 
1751 GGCGTGATTG CCAGC