MG1655
W3110
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Gene Report : mhpR
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 9-1 (LD)  ,  OCR36,37-6 (LD 9C::Ap) (D)  ,  OCR37 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  mhpR
Related strains
     Strains Search Search strains by gene name:  mhpR   Search strains by all related name:  mhpR b0346 ECK0343 f315 f315b JW0337

General information  (Go to Linear View:)
 Gene Name mhpR  
 Alternative name b0346,ECK0343,f315,f315b,JW0337  
 Location, Length 366,811 - 367,644 (  -  ) ;   7.91 min ; 834 (bp) ,   277 (aa) Go to Linear View
 Product DNA-binding transcriptional activator, 3HPP-binding  
 Operon Name mhpR-lacI  
 Note transcriptional regulator for mhp operon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0019395 - fatty acid oxidation; GO_process: GO:0006350 - transcription  
 Function regulator; Not classified  
 Gene Ontology GO:0003677; DNA binding ( mhpR )
GO:0006350; transcription ( mhpR )
GO:0006355; regulation of transcription, DNA-dependent ( mhpR )
GO:0019439; aromatic compound catabolic process ( mhpR )
 PID 145693096  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) YIAJ_ECOLI ( P37671 )
    -  Protein name Putative HTH-type transcriptional regulator yiaJ.  
    -  Synonyms  
    -  Gene name Name=yiaJ; OrderedLocusNames=b3574;  

 Linear View (Whole Mode)
View Location
   355.0  –  380.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP mhpR (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, The Crystal Structure Of A Putative Transcriptional Regulator Rha06195 From Rhodococcus Sp. Rha1  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Mhp operon transcriptional activator  
         PSI-BLAST Mhp operon transcriptional activator
    nr     (database updated : 2007.02.20 )
         BLAST DNA-binding transcriptional activator, 3HPP-binding [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION     

Other Cross-Reference
    COG COG1414K 
    EcoCyc mhpR 

MMBR References
In J. Blair (ed.), Chemistry and biology of pteridines. W. de Gruyter, New York, N.Y. 1983:585-589
Isolation and characterization of an E. coli mutant affected in dihydrofolate- and folylpolyglutamate-synthetase.
Ferone, R., S. C. Singer, M. H. Hanlon, and S. Roland.
J Bacteriol. 1997;179:2573-2581
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
Ferrandez, A., J. L. Garcia, and E. Diaz.
Ph.D. thesis. University of Minnesota, Minneapolis-St. Paul. 1983
The degradation of 3-phenylpropionic acid by Escherichia coli.
Burlingame, R. P.
J Bacteriol. 1986;168(1):55-64.
Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation.
Burlingame RP, Wyman L, Chapman PJ. ( 3531186 )

Sequences
Amino acid
FASTA format
0001 MQNNEQTEYK TVRGLTRGLM LLNMLNKLDG GASVGLLAEL SGLHRTTVRR LLETLQEEGY VRRSPSDDSF 
0071 RLTIKVRQLS EGFRDEQWIS ALAAPLLGDL LREVVWPTDV STLDVDAMVV RETTHRFSRL SFHRAMVGRR 
0141 LPLLKTASGL TWLAFCPEQD RKELIEMLAS RPGDDYQLAR EPLKLEAILA RARKEGYGQN YRGWDQEEKI 
0211 ASIAVPLRSE QRVIGCLNLV YMASAMTIEQ AAEKHLPALQ RVAKQIEEGV ESQAILVAGR RSGMHLR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             tgcgctcagt ataggaaggg tgttttcggc 
-070 tacaatcaaa acatgcccga atgtgcacca ggtgcaccac gttgttttaa ctatagaaat gtcaattaat 
0001 atgcagaaca atgagcagac ggaatacaaa accgtgcgcg gcttaacccg cggtctaatg ttattaaata 
0071 tgttaaataa acttgatggc ggtgccagcg tcgggctgct ggcggaactc agcggcctgc atcgcaccac 
0141 tgtgcggcga ctgctggaga cgctgcagga agagggatat gtccgccgta gcccctccga tgatagtttt 
0211 cgactgacca tcaaagtgcg gcaattaagc gaaggatttc gtgacgaaca gtggatttct gcactggcgg 
0281 ccccactgct gggcgatctg ttgcgcgaag tggtatggcc gacagatgtg tccacgctgg atgttgatgc 
0351 aatggtggta cgcgaaacca ctcaccgttt cagccgctta tcctttcacc gggcaatggt cgggcgacgt 
0421 ttgccgcttc tgaaaaccgc ctcgggcctg acctggctgg ccttttgccc ggaacaagac cgcaaggaat 
0491 taatcgaaat gttagcctcc cgccccggtg atgactatca actggcacgg gaaccgttaa agctggaagc 
0561 cattctggcg cgcgcgcgca aagagggtta cggacagaac taccgcggct gggatcagga ggagaagatc 
0631 gcctctatcg ccgtaccgct gcgcagtgaa caacgggtga ttggctgtct gaatctggtg tatatggcga 
0701 gcgcaatgac cattgaacag gcagcggaaa agcatcttcc ggcgctacaa cgggtagcaa aacagatcga 
0771 agaaggggtt gaatcgcagg ctattctggt ggccggaagg cgaagcggca tgcatttacg ttgacaccat 
0841 cgaatggcgc aaaacctttc gcggtatggc atgatagcgc ccggaagaga gtcaattcag ggtggtgaat 
0911 gtgaaaccag taacgttata cgat