MG1655
W3110
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Gene Report : lacA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 9-1 (LD)  ,  DE(gpt-lac)5  ,  DE(argF-lac)169  ,  OCR36,37-6 (LD 9C::Ap) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  lacA
Related strains
     Strains Search Search strains by gene name:  lacA   Search strains by all related name:  lacA b0342 ECK0339 f203 JW0333

General information  (Go to Linear View:)
 Gene Name lacA  
 Alternative name b0342,ECK0339,f203,JW0333  
 Location, Length 360,473 - 361,084 (  -  ) ;   7.77 min ; 612 (bp) ,   203 (aa) Go to Linear View
 Product thiogalactoside acetyltransferase  
 Operon Name lacZYA  
 Note GO_component: GO:0005737 - cytoplasm; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function enzyme; Degradation of small molecules: Carbon compounds  
 Gene Ontology GO:0005737; cytoplasm ( lacA )
GO:0005989; lactose biosynthetic process ( lacA )
GO:0008415; acyltransferase activity ( lacA )
GO:0008870; galactoside O-acetyltransferase activity ( lacA )
GO:0016740; transferase activity ( lacA )
 PID 1786537  
 EC number
  (KEGG Pathway)
 
2.3.1.18  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene lacA ( EG10524 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) THGA_ECOLI ( P07464 ; P77862 )
    -  Protein name Galactoside O-acetyltransferase  
    -  Synonyms EC 2.3.1.18, GAT, Thiogalactoside acetyltransferase  
    -  Gene name Name=lacA; OrderedLocusNames=b0342;  

 Linear View (Whole Mode)
View Location
   350.0  –  375.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP lacA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Galactoside Acetyltransferase In Complex With Coenzyme A  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Galactoside O-acetyltransferase  
         PSI-BLAST UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
    nr     (database updated : 2007.02.20 )
         BLAST galactoside O-acetyltransferase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    HEXAPEP_TRANSFERASES     

Other Cross-Reference
    COG COG0110R 
    EcoCyc lacA 

MMBR References
Proc Natl Acad Sci U S A. 1985;82:6414-6418
DNA sequence of the lactose operon: the lacA gene and the transcriptional termination region.
Hediger, M. A., D. F. Johnson, D. P. Nierlich, and I. Zabin.
Genetics 1963;48:157-169
The genetic basis of hypersynthesis of beta-galactoside.
Horiuchi, T., S. Horiuchi, and A. Novick.

Sequences
Amino acid
FASTA format
0001 MNMPMTERIR AGKLFTDMCE GLPEKRLRGK TLMYEFNHSH PSEVEKRESL IKEMFATVGE NAWVEPPVYF 
0071 SYGSNIHIGR NFYANFNLTI VDDYTVTIGD NVLIAPNVTL SVTGHPVHHE LRKNGEMYSF PITIGNNVWI 
0141 GSHVVINPGV TIGDNSVIGA GSIVTKDIPP NVVAAGVPCR VIREINDRDK HYYFKDYKVE SSV

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             ccctgctgcg tcgtcaggtg aatgaagtcg 
-070 cttaagcaat caatgtcgga tgcggcgcga gcgccttatc cgaccaacat atcataacgg agtgatcgca 
0001 ttgaacatgc caatgaccga aagaataaga gcaggcaagc tatttaccga tatgtgcgaa ggcttaccgg 
0071 aaaaaagact tcgtgggaaa acgttaatgt atgagtttaa tcactcgcat ccatcagaag ttgaaaaaag 
0141 agaaagcctg attaaagaaa tgtttgccac ggtaggggaa aacgcctggg tagaaccgcc tgtctatttc 
0211 tcttacggtt ccaacatcca tataggccgc aatttttatg caaatttcaa tttaaccatt gtcgatgact 
0281 acacggtaac aatcggtgat aacgtactga ttgcacccaa cgttactctt tccgttacgg gacaccctgt 
0351 acaccatgaa ttgagaaaaa acggcgagat gtactctttt ccgataacga ttggcaataa cgtctggatc 
0421 ggaagtcatg tggttattaa tccaggcgtc accatcgggg ataattctgt tattggcgcg ggtagtatcg 
0491 tcacaaaaga cattccacca aacgtcgtgg cggctggcgt tccttgtcgg gttattcgcg aaataaacga 
0561 ccgggataag cactattatt tcaaagatta taaagttgaa tcgtcagttt aaattataaa aattgcctga 
0631 tacgctgcgc ttatcaggcc tacaagttca gcgatctaca ttagccgcat ccggcatgaa caaagcgcag 
0701 gaacaagcgt cg