MG1655
W3110
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Gene Report : cynR
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 9-1 (LD)  ,  DE(gpt-lac)5  ,  DE(argF-lac)169  ,  OCR36,37-6 (LD 9C::Ap) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  cynR
Related strains
     Strains Search Search strains by gene name:  cynR   Search strains by all related name:  cynR b0338 ECK0335 JW5894

General information  (Go to Linear View:)
 Gene Name cynR  
 Alternative name b0338,ECK0335,JW5894  
 Location, Length 357,015 - 357,914 (  -  ) ;   7.69 min ; 900 (bp) ,   299 (aa) Go to Linear View
 Product transcriptional activator of cyn operon; autorepressor  
 Operon Name cynR  
 Note cyn operon positive regulator; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0006350 - transcription; GO_process: GO:0006805 - xenobiotic metabolic process  
 Function regulator; Central intermediary metabolism: Pool, multipurpose conversions  
 Gene Ontology GO:0003677 ; DNA binding ( cynR )
GO:0003700 ; transcription factor activity ( cynR )
GO:0005737 ; cytoplasm ( cynR )
GO:0006350 ; transcription ( cynR )
GO:0006355 ; regulation of transcription, DNA-dependent ( cynR )
 PID 157672245  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) CYNR_ECOLI ( P27111 )
    -  Protein name HTH-type transcriptional regulator cynR  
    -  Synonyms Cyn operon transcriptional activator  
    -  Gene name Name=cynR; OrderedLocusNames=b0338;  

 Linear View (Whole Mode)
View Location
   345.0  –  370.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP cynR (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Cofactor Binding Fragment Of Cysb From Klebsiella Aerogenes  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST HTH-type transcriptional regulator cynR  
         PSI-BLAST Putative HTH-type transcriptional regulator ywbI
    nr     (database updated : 2007.02.20 )
         BLAST cyn operon transcriptional activator [Escherichia coli]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION    HTH_LYSR_FAMILY     

Other Cross-Reference
    COG COG0583K 
    EcoCyc cynR 

MMBR References
FEMS Microbiol Rev. 1990;7(3-4):247-52.
The cyanase operon and cyanate metabolism.
Anderson PM, Sung YC, Fuchs JA. ( 2094285 )
J Bacteriol. 1993;175:7990-7999
Expression and purification of the cynR regulatory gene product: CynR is a DNA-binding protein.
Lamblin, A. F., and J. A. Fuchs.
J Bacteriol. 1992;174:3645-3650
The Escherichia coli K-12 cyn operon is positively regulated by a member of the lysR family.
Sung, Y.-C., and J. A. Fuchs.

Sequences
Amino acid
FASTA format
0001 MLSRHINYFL AVAEHGSFTR AASALHVSQP ALSQQIRQLE ESLGVPLFDR SGRTIRLTDA GEVWRQYASR 
0071 ALQELGAGKR AIHDVADLTR GSLRIAVTPT FTSYFIGPLM ADFYARYPSI TLQLQEMSQE KIEDMLCRDE 
0141 LDVGIAFAPV HSPELEAIPL LTESLALVVA QHHPLAVHEQ VALSRLHDEK LVLLSAEFAT REQIDHYCEK 
0211 AGLHPQVVIE ANSISAVLEL IRRTSLSTLL PAAIATQHDG LKAISLAPPL LERTAVLLRR KNSWQTAAAK 
0281 AFLHMALDKC AVVGGNESR

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             tctgtctgtc tctggaatga gaggcagact 
-070 actcgccgat tgtcataagg taaaagtctc atttatgatg agttccattg gatttactta taggttgcga 
0001 atgctctctc gacatatcaa ttattttctt gccgtggctg aacatggcag cttcacccgt gccgccagtg 
0071 cgttgcacgt ctcccaacct gcgctttccc agcagattcg ccagttagag gagagtttag gcgtgccgct 
0141 gtttgaccgt agcgggcgaa cgattcgtct cactgatgca ggagaagtct ggcgacagta cgccagccgg 
0211 gcgttacagg aactgggggc gggtaaacgg gcgattcatg atgttgccga tctgacgcga ggatcgctgc 
0281 gtatcgccgt cacccccacc tttacgagct actttatcgg ccccttaatg gcggatttct atgcgcgcta 
0351 tcccagcatc acgctccagc tacaggaaat gtcgcaggag aaaatcgagg atatgctttg ccgcgacgag 
0421 ttggacgttg ggattgcctt cgcgcctgtg cattcgccgg agctggaggc aattccttta ctgacagaaa 
0491 gtttagcgtt agtcgtggcg caacatcatc cgctggccgt ccatgaacag gtggcgttga gtcgcttgca 
0561 tgatgaaaaa ctggtcctgc tcagcgcgga atttgccacc agagagcaaa ttgaccacta ctgcgagaaa 
0631 gcggggctac atccacaggt ggtcattgag gcgaactcaa ttagcgcggt tctggagctg attcgccgca 
0701 cttccctttc cacattgtta ccagcagcga ttgccacaca acatgacggg cttaaagcta tttctcttgc 
0771 cccgccacta ctggagagaa cggcggtttt gttgcggcgg aaaaatagct ggcagacagc cgccgcgaag 
0841 gcatttttgc acatggcgtt ggataaatgc gcggttgttg gcggaaatga atcacggtag ccgctgacac 
0911 aggtctgcgg ctggaattgc ctgatgcgct acgcttatca ggcctacgag ttcagtgctc tacgtaggcc 
0981 ggataaggcg ttcacgccgc