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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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|
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Deletion
|
9-1
(LD)
,
DE(gpt-lac)5
,
DE(argF-lac)169
,
OCR36,37-6 (LD 9C::Ap)
(D)
|
|
Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
codB
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Related strains
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Strains Search
|
Search strains by gene name:
codB
Search strains by all related name:
codB b0336 ECK0333 JW0327
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General information (Go to Linear View: )
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Gene Name
|
codB
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Alternative name
|
b0336,ECK0333,JW0327
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Location, Length
|
354,146 - 355,405
(
+
)
;
7.63
min
;
1260
(bp) ,
419
(aa)
|
|
Product
|
cytosine transporter
|
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Operon Name
|
codBA
|
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Note
|
cytosine permease/transport; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion
|
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Function
|
transport; Transport of small molecules: Nucleosides, purines, pyrimidines
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Gene Ontology
|
GO:0005886
;
plasma membrane ( codB )
GO:0006810
;
transport ( codB )
GO:0015205
;
nucleobase transmembrane transporter activity ( codB )
GO:0015931
;
nucleobase, nucleoside, nucleotide and nucleic acid transport ( codB )
GO:0016020
;
membrane ( codB )
GO:0016021
;
integral to membrane ( codB )
GO:0019858
;
cytosine metabolic process ( codB )
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PID
|
1786530
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
CODB_ECOLI
(
P25525
)
|
|
- Protein name
|
Cytosine permease.
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- Synonyms
|
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- Gene name
|
Name=codB; OrderedLocusNames=b0336, c0455;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
codB
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Cytosine permease
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|
PSI-BLAST
|
Cytosine permease
|
|
nr
(database updated :
2007.02.20
)
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BLAST
|
cytosine transporter [Escherichia coli K12]
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|
Pfam 28.0
(database updated :
2015-05
)
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Pfam
|
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PROSITE
|
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PROSITE
|
ASN_GLYCOSYLATION
GLYCOSAMINOGLYCAN
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
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MMBR References
|
Mol Gen Genet. 1972;118(4):323-5.
Location of gene specifying cytosine deaminase in Escherichia coli.
Ahmad SI, Pritchard RH.
(
4570159
)
|
Mol Microbiol. 1992;6(10):1335-44.
Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase.
Danielsen S, Kilstrup M, Barilla K, Jochimsen B, Neuhard J.
(
1640834
)
|
Arch Microbiol. 1989;152(2):115-8.
Pyrimidine, purine and nitrogen control of cytosine deaminase synthesis in Escherichia coli K 12. Involvement of the glnLG and purR genes in the regulation of codA expression.
Andersen L, Kilstrup M, Neuhard J.
(
2673119
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH DFFLAVLIGN LLLGIYTSFL
0071 GYIGAKTGLT THLLARFSFG VKGSWLPSLL LGGTQVGWFG VGVAMFAIPV GKATGLDINL LIAVSGLLMT
0141 VTVFFGISAL TVLSVIAVPA IACLGGYSVW LAVNGMGGLD ALKAVVPAQP LDFNVALALV VGSFISAGTL
0211 TADFVRFGRN AKLAVLVAMV AFFLGNSLMF IFGAAGAAAL GMADISDVMI AQGLLLPAIV VLGLNIWTTN
0281 DNALYASGLG FANITGMSSK TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY
0351 EHFATTRMMS VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP ILNRKTTAAM THVEANSVE
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TAAAAAATAT ATTTCCCCAC GAAAACGATT
-070 GCTTTTTATC TTCAGATGAA TAGAATGCGG CGGATTTTTT GGGTTTCAAA CAGCAAAAAG GGGGAATTTC
0001 gtgtcgcaag ataacaactt tagccagggg ccagtcccgc agtcggcgcg gaaaggggta ttggcattga
0071 cgttcgtcat gctgggatta accttctttt ccgccagtat gtggaccggc ggcactctcg gaaccggtct
0141 tagctatcat gatttcttcc tcgcagttct catcggtaat cttctcctcg gtatttacac ttcatttctc
0211 ggttacattg gcgcaaaaac cggcctgacc actcatcttc ttgctcgctt ctcgtttggt gttaaaggct
0281 catggctgcc ttcactgcta ctgggcggaa ctcaggttgg ctggtttggc gtcggtgtgg cgatgtttgc
0351 cattccggtg ggtaaggcaa ccgggctgga tattaatttg ctgattgccg tttccggttt actgatgacc
0421 gtcaccgtct tttttggcat ttcggcgctg acggttcttt cggtgattgc ggttccggct atcgcctgcc
0491 tgggcggtta ttccgtgtgg ctggctgtta acggcatggg cggcctggac gcattaaaag cggtcgttcc
0561 cgcacaaccg ttagatttca atgtcgcgct ggcgctggtt gtggggtcat ttatcagtgc gggtacgctc
0631 accgctgact ttgtccggtt tggtcgcaat gccaaactgg cggtgctggt ggcgatggtg gcctttttcc
0701 tcggcaactc gttgatgttt attttcggtg cagcgggcgc tgcggcactg ggcatggcgg atatctctga
0771 tgtgatgatt gctcagggcc tgctgctgcc tgcgattgtg gtgctggggc tgaatatctg gaccaccaac
0841 gataacgcac tctatgcgtc gggtttaggt ttcgccaaca ttaccgggat gtcgagcaaa accctttcgg
0911 taatcaacgg tattatcggt acggtctgcg cattatggct gtataacaat tttgtcggct ggttgacctt
0981 cctttcggca gctattcctc cagtgggtgg cgtgatcatc gccgactatc tgatgaaccg tcgccgctat
1051 gagcactttg cgaccacgcg tatgatgagt gtcaattggg tggcgattct ggcggtcgcc ttggggattg
1121 ctgcaggcca ctggttaccg ggaattgttc cggtcaacgc ggtattaggt ggcgcgctga gctatctgat
1191 ccttaacccg attttgaatc gtaaaacgac agcagcaatg acgcatgtgg aggctaacag tgtcgaataa
1261 CGCTTTACAA ACAATTATTA ACGCCCGGTT ACCAGGCGAA GAGGGGCTGT GGCAGATTCA TCTGCAGGAC
1331 GGAAAAATCA GCGCCATTGA TGCGCAATCC
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