MG1655
W3110
Search for
Japanese | English
Gene Report : aroB
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Mol Microbiol. 1997;25(4):661-70.
Overinitiation of chromosome replication in the Escherichia coli dnaAcos mutant depends on activation of oriC function by the dam gene product.
Katayama T, Akimitsu N, Mizushima T, Miki T, Sekimizu K. ( 9379896 )
     Deletion OCL19,20-1 (D)  ,  OCL19,20-2 (D)  ,  OCL19,20-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  aroB
Related strains
     Strains Search Search strains by gene name:  aroB   Search strains by all related name:  aroB b3389 ECK3376 f362 JW3352

General information  (Go to Linear View:)
 Gene Name aroB  
 Alternative name b3389,ECK3376,f362,JW3352  
 Location, Length 3,515,420 - 3,516,508 (  -  ) ;   75.77 min ; 1089 (bp) ,   362 (aa) Go to Linear View
 Product 3-dehydroquinate synthase  
 Operon Name aroKB-damX-dam-rpe-gph-trpS  
 Note GO_process: GO:0009423 - chorismate biosynthetic process  
 Function enzyme; Amino acid biosynthesis: Chorismate  
 Gene Ontology GO:0003856 ; 3-dehydroquinate synthase activity ( aroB )
GO:0005737 ; cytoplasm ( aroB )
GO:0008652 ; amino acid biosynthetic process ( aroB )
GO:0009073 ; aromatic amino acid family biosynthetic process ( aroB )
GO:0016829 ; lyase activity ( aroB )
GO:0050897 ; cobalt ion binding ( aroB )
 PID 1789791  
 EC number
  (KEGG Pathway)
 
4.2.3.4  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) AROB_ECOLI ( P07639 )
    -  Protein name 3-dehydroquinate synthase  
    -  Synonyms EC 4.2.3.4  
    -  Gene name Name=aroB; OrderedLocusNames=b3389;  

 Linear View (Whole Mode)
View Location
   3505.0  –  3530.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP aroB (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of Staphlyococcus Aureus 3-Dehydroquinate Synthase (Dhqs) In Complex With Zn2+, Nad+ And Carbaphosphonate  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST 3-dehydroquinate synthase  
         PSI-BLAST 3-dehydroquinate synthase
    nr     (database updated : 2007.02.20 )
         BLAST 3-dehydroquinate synthase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG0337E 
    EcoCyc aroB 

MMBR References
FEBS Lett. 1986;200(1):11-7.
The complete amino acid sequence of 3-dehydroquinate synthase of Escherichia coli K12.
Millar G, Coggins JR. ( 3009224 )

Sequences
Amino acid
FASTA format
0001 MERIVVTLGE RSYPITIASG LFNEPASFLP LKSGEQVMLV TNETLAPLYL DKVRGVLEQA GVNVDSVILP 
0071 DGEQYKSLAV LDTVFTALLQ KPHGRDTTLV ALGGGVVGDL TGFAAASYQR GVRFIQVPTT LLSQVDSSVG 
0141 GKTAVNHPLG KNMIGAFYQP ASVVVDLDCL KTLPPRELAS GLAEVIKYGI ILDGAFFNWL EENLDALLRL 
0211 DGPAMAYCIR RCCELKAEVV AADERETGLR ALLNLGHTFG HAIEAEMGYG NWLHGEAVAA GMVMAARTSE 
0281 RLGQFSSAET QRIITLLKRA GLPVNGPREM SAQAYLPHML RDKKVLAGEM RLILPLAIGK SEVRSGVSHE 
0351 LVLNAIADCQ SA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             aagtggttgc aaaccagatt attcacatgc 
-070 tggaaagcaa ctaattctgg ctttatatac actcgtctgc gggtacagta attaaggtgg atgtcgcgtt 
0001 atggagagga ttgtcgttac tctcggggaa cgtagttacc caattaccat cgcatctggt ttgtttaatg 
0071 aaccagcttc attcttaccg ctgaaatcgg gcgagcaggt catgttggtc accaacgaaa ccctggctcc 
0141 tctgtatctc gataaggtcc gcggcgtact tgaacaggcg ggtgttaacg tcgatagcgt tatcctccct 
0211 gacggcgagc agtataaaag cctggctgta ctcgataccg tctttacggc gttgttacaa aaaccgcatg 
0281 gtcgcgatac tacgctggtg gcgcttggcg gcggcgtagt gggcgatctg accggcttcg cggcggcgag 
0351 ttatcagcgc ggtgtccgtt tcattcaagt cccgacgacg ttactgtcgc aggtcgattc ctccgttggc 
0421 ggcaaaactg cggtcaacca tcccctcggt aaaaacatga ttggcgcgtt ctaccaacct gcttcagtgg 
0491 tggtggatct cgactgtctg aaaacgcttc ccccgcgtga gttagcgtcg gggctggcag aagtcatcaa 
0561 atacggcatt attcttgacg gtgcgttttt taactggctg gaagagaatc tggatgcgtt gttgcgtctg 
0631 gacggtccgg caatggcgta ctgtattcgc cgttgttgtg aactgaaggc agaagttgtc gccgccgacg 
0701 agcgcgaaac cgggttacgt gctttactga atctgggaca cacctttggt catgccattg aagctgaaat 
0771 ggggtatggc aattggttac atggtgaagc ggtcgctgcg ggtatggtga tggcggcgcg gacgtcggaa 
0841 cgtctcgggc agtttagttc tgccgaaacg cagcgtatta taaccctgct caagcgggct gggttaccgg 
0911 tcaatgggcc gcgcgaaatg tccgcgcagg cgtatttacc gcatatgctg cgtgacaaga aagtccttgc 
0981 gggagagatg cgcttaattc ttccgttggc aattggtaag agtgaagttc gcagcggcgt ttcgcacgag 
1051 cttgttctta acgccattgc cgattgtcaa tcagcgtaac aacaagaaag gtcaggccgc ttatcaagcg 
1121 gtctattagc ttcaggttaa ttgcaacgtg gtaagcatta accttttagt ggggtgttaa atggatgaa