MG1655
W3110
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Gene Report : nirC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL20 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  nirC
Related strains
     Strains Search Search strains by gene name:  nirC   Search strains by all related name:  nirC b3367 ECK3355 JW3330 o184

General information  (Go to Linear View:)
 Gene Name nirC  
 Alternative name b3367,ECK3355,JW3330,o184  
 Location, Length 3,495,025 - 3,495,831 (  +  ) ;   75.33 min ; 807 (bp) ,   268 (aa) Go to Linear View
 Product nitrite transporter  
 Operon Name nirBDC-cysG  
 Note nitrite reductase activity; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006807 - nitrogen compound metabolic process  
 Function enzyme; Energy metabolism, carbon: Anaerobic respiration  
 Gene Ontology GO:0005215 ; transporter activity ( nirC )
GO:0005886 ; plasma membrane ( nirC )
GO:0006810 ; transport ( nirC )
GO:0016020 ; membrane ( nirC )
GO:0016021 ; integral to membrane ( nirC )
GO:0042128 ; nitrate assimilation ( nirC )
 PID 87082249  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) NIRC_ECOLI ( P11097 ; P78112 )
    -  Protein name Potential nitrite transporter.  
    -  Synonyms  
    -  Gene name Name=nirC; OrderedLocusNames=b3367, SF3386, S4377;  

 Linear View (Whole Mode)
View Location
   3485.0  –  3510.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP nirC (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Dihydrofolate Reductase (E.C.1.5.1.3)  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Probable nitrite transporter  
         PSI-BLAST Probable nitrite transporter
    nr     (database updated : 2007.02.20 )
         BLAST COG2116: Formate/nitrite family of transporters [Escherichia coli E24377A]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    FORMATE_NITRITE_TP_1    FORMATE_NITRITE_TP_2     

Other Cross-Reference
    COG COG2116P 
    EcoCyc nirC 

MMBR References
Mol Microbiol. 1992;6(19):2805-13.
Transcriptional control, translation and function of the products of the five open reading frames of the Escherichia coli nir operon.
Harborne NR, Griffiths L, Busby SJ, Cole JA. ( 1435259 )
Eur J Biochem. 1990;191:315-323
Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome.
Peakman, T. C., J. Crouzet, J.-F. Mayaux, S. J. Busby, S. Mohan, N. Harborne, J. C. Wootton, R. Nicolson, and J. A. Cole.

Sequences
Amino acid
FASTA format
0001 MFTDTINKCA ANAARIARLS ANNPLGFWVS SAMAGAYVGL GIILIFTLGN LLDPSVRPLV MGATFGIALT 
0071 LVIIAGSELF TGHTMFLTFG VKAGSISHGQ MWAILPQTWL GNLVGSVFVA MLYSWGGGSL LPVDTSIVHS 
0141 VALAKTTAPA MVLFFKGALC NWLVCLAIWM ALRTEGAAKF IAIWWCLLAF IASGYEHSIA NMTLFALSWF 
0211 GNHSEAYTLA GIGHNLLWVT LGNTLSGAVF MGLGYWYATP KANRPVADKF NQTETAAG

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             CCCCTTTTTG CATGGTCCTG TAATAATCTT 
-070 CGGTATATTG CAGGACATTT TTTAAACTTT TTGTTTTATT TTTTGTTTTT ATTTTTTAAA GGATAATCAA 
0001 atgtttacag acactattaa taagtgtgcg gctaacgctg cgcgcattgc acgcctgtcg gcaaataacc 
0071 cgctcggctt ttgggtcagc tccgccatgg cgggcgcgta tgtgggtctt gggatcatcc tgattttcac 
0141 gctcggtaat ttgctcgatc catccgtacg ccctttggtg atgggcgcga cctttggtat cgccttaacg 
0211 ctggtgatta tcgccggttc tgaactgttc accggacaca ccatgttcct cacctttggg gtaaaagcgg 
0281 gcagcatcag ccacgggcaa atgtgggcaa tcctgccgca aacctggctg ggtaacctgg tcggttccgt 
0351 cttcgttgcc atgctctata gctggggcgg cggtagcctg ctgccggtag ataccagcat cgttcactcc 
0421 gtcgcgctgg ctaaaaccac tgcaccggca atggtactct tcttcaaagg tgcattgtgt aactggctgg 
0491 tttgcctggc aatctggatg gcgctgcgca ctgaaggggc ggcgaaattt atcgctatct ggtggtgtct 
0561 gctggcattt atcgcgtccg gctacgagca ctctatcgct aacatgacgc tgttcgcgct ctcctggttc 
0631 ggcaaccaca gcgaagccta cacgctggcg ggtattggtc ataacctgct gtgggtgacg ctgggtaata 
0701 ctttatcagg tgccgtattc atgggattgg gttattggta tgctacgccg aaagcgaatc gtccggttgc 
0771 ggacaaattt aatcaaactg aaacggctgc cggttaaTTA CTAAGGGGTT TTTACGTGGA TCATTTGCCT 
0841 ATATTTTGCC AATTACGCGA TCGCGACTGT CTGATTGTCG GCGGTGGTGA TGTCGCGGAA CGCAAAG