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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
|
Genetika. 1985;21(6):1068-9.
[Generation of deletions in the region of the crp gene on the Escherichia coli chromosome]
Kulakauskas ST, Sukhodolets VV.
(
3896929
)
|
|
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Deletion
|
OCL21
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
argD
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Related strains
|
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Strains Search
|
Search strains by gene name:
argD
Search strains by all related name:
argD alaB Arg1 argG b3359 dapC dtu ECK3347 f406 JW3322
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General information (Go to Linear View: )
|
|
Gene Name
|
argD
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Alternative name
|
alaB,Arg1,argG,b3359,dapC,dtu,ECK3347,f406,JW3322
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Location, Length
|
3,486,982 - 3,488,202
(
-
)
;
75.16
min
;
1221
(bp) ,
406
(aa)
|
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Product
|
bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase
|
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Operon Name
|
argD
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Note
|
acetylornithine delta-aminotransferase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006526 - arginine biosynthetic process; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate
|
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Function
|
enzyme; Amino acid biosynthesis: Arginine
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Gene Ontology
|
GO:0000166
;
nucleotide binding ( argG )
GO:0003824
;
catalytic activity ( argD )
GO:0003992
;
acetylornithine transaminase activity ( argD )
GO:0004055
;
argininosuccinate synthase activity ( argG )
GO:0005515
;
protein binding ( argG )
GO:0005524
;
ATP binding ( argG )
GO:0005737
;
cytoplasm ( argD )
GO:0005737
;
cytoplasm ( argG )
GO:0006525
;
arginine metabolic process ( argD )
GO:0006526
;
arginine biosynthetic process ( argD )
GO:0006526
;
arginine biosynthetic process ( argG )
GO:0008483
;
transaminase activity ( argD )
GO:0008652
;
amino acid biosynthetic process ( argD )
GO:0008652
;
amino acid biosynthetic process ( argG )
GO:0009016
;
succinyldiaminopimelate transaminase activity ( argD )
GO:0009085
;
lysine biosynthetic process ( argD )
GO:0016740
;
transferase activity ( argD )
GO:0016874
;
ligase activity ( argG )
GO:0030170
;
pyridoxal phosphate binding ( argD )
|
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PID
|
1789759
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EC number
(KEGG Pathway)
|
2.6.1.11
2.6.1.17
|
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
argD
(
EG10066
)
|
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
[
4
more]
)
|
Entry name(Acc.no)
|
ARGD_ECOLI
(
P18335
)
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- Protein name
|
Acetylornithine/succinyldiaminopimelate aminotransferase
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- Synonyms
|
EC 2.6.1.11, EC 2.6.1.17, ACOAT, Succinyldiaminopimelate transferase, DapATase
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- Gene name
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Name=argD; Synonyms=dapC, dtu; OrderedLocusNames=b3359;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
argG
(
homologous genes of other bacterias
)
argD
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
|
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PSI-BLAST
|
Chain A, Ornithine Aminotransferase
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
|
Acetylornithine/succinyldiaminopimelate aminotransferase
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PSI-BLAST
|
Acetylornithine aminotransferase
|
|
nr
(database updated :
2007.02.20
)
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BLAST
|
bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase [Escherichia coli K12]
|
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Pfam 28.0
(database updated :
2015-05
)
|
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Pfam
|
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PROSITE
|
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PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
AA_TRANSFER_CLASS_3
|
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MMBR References
|
J Bacteriol. 1976;128(2):528-35.
Isolation and partial characterization of an argR mutant of Salmonella typhimurium.
Kelln RA, O'Donovan GA.
(
185197
)
|
J Bacteriol. 1974;118(3):928-34.
Proline excretion and indirect suppression in Escherichia coli and Salmonella typhimurium.
Berg CM, Rossi JJ.
(
4598010
)
|
Gene. 1983;24(2-3):335-9.
Cloning the Escherichia coli K-12 argD gene specifying acetylornithine delta-transaminase.
Riley M, Glansdorff N.
(
6357954
)
|
J Bacteriol. 1975;123(3):898-904.
Accumulation of arginine precursors in Escherichia coli: effects on growth, enzyme repression, and application to the forward selection of arginine auxotrophs.
Crabeel M, Charlier D, Cunin R, Boyen A, Glansdorff N, Pierard A.
(
1099083
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MAIEQTAITR ATFDEVILPI YAPAEFIPVK GQGSRIWDQQ GKEYVDFAGG IAVTALGHCH PALVNALKTQ
0071 GETLWHISNV FTNEPALRLG RKLIEATFAE RVVFMNSGTE ANETAFKLAR HYACVRHSPF KTKIIAFHNA
0141 FHGRSLFTVS VGGQPKYSDG FGPKPADIIH VPFNDLHAVK AVMDDHTCAV VVEPIQGEGG VTAATPEFLQ
0211 GLRELCDQHQ ALLVFDEVQC GMGRTGDLFA YMHYGVTPDI LTSAKALGGG FPISAMLTTA EIASAFHPGS
0281 HGSTYGGNPL ACAVAGAAFD IINTPEVLEG IQAKRQRFVD HLQKIDQQYD VFSDIRGMGL LIGAELKPQY
0351 KGRARDFLYA GAEAGVMVLN AGPDVMRFAP SLVVEDADID EGMQRFAHAV AKVVGA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ttcctgcatc gctgatttct gattgccatt
-070 tagtgatttt ttatgcatat tttgtggtta taatttcaca tttgtttatg cgtaacaggg tgatcatgag
0001 atggcaattg aacaaacagc aattacacgc gcgactttcg atgaagtgat cctgccgatt tatgctccgg
0071 cagagtttat tccggtaaaa ggtcagggca gccgaatctg ggatcagcaa ggcaaggagt atgtcgattt
0141 cgcgggtggc attgcagtta cggcgttggg ccattgccat cctgcgctgg tgaacgcgtt aaaaacccag
0211 ggcgaaactc tgtggcatat cagtaacgtt ttcaccaatg aaccggcgct gcgtcttggg cgtaaactga
0281 ttgaggcaac gtttgccgaa cgcgtggtgt ttatgaactc cggcacggaa gctaacgaaa ccgcctttaa
0351 actggcacgc cattacgcct gtgtgcgtca tagcccgttc aaaaccaaaa ttattgcctt ccataacgct
0421 tttcatggtc gctcgctgtt taccgtttcg gtgggtgggc agccaaaata ttccgacggc tttgggccga
0491 aaccggcaga catcatccac gttcccttta acgatctcca tgcagtgaaa gcggtgatgg atgatcacac
0561 ctgtgcggtg gtggttgagc cgatccaggg cgagggcggt gtgacggcag cgacgccaga gtttttgcag
0631 ggcttgcgcg agctgtgcga tcaacatcag gcattattgg tgtttgatga agtgcagtgc gggatggggc
0701 ggaccggcga tttgtttgct tacatgcact acggcgttac gccggatatt ctgacctctg cgaaagcgtt
0771 aggcggcggc ttcccgatta gcgccatgct gaccacggcg gaaattgctt ctgcgtttca tcctggttct
0841 cacggttcca cctacggcgg taatcctctg gcctgtgcag tagcgggggc ggcgtttgat atcatcaata
0911 cccctgaagt gctggaaggc attcaggcga aacgccagcg ttttgttgac catctgcaga agatcgatca
0981 gcagtacgat gtatttagcg atattcgcgg tatggggctg ttgattggcg cagagctgaa accacagtac
1051 aaaggtcggg cgcgtgattt cctgtatgcg ggcgcagagg ctggcgtaat ggtgctgaat gccggaccgg
1121 atgtgatgcg ttttgcaccg tcgctggtgg tggaagatgc ggatatcgat gaagggatgc aacgtttcgc
1191 ccacgcggtg gcgaaggtgg ttggggcgta aatacgaagc atcaggcaaa agatgtcgga tgcggcgtga
1261 atgccttatc cgatggttta gcctgcatta cgccttcgaa tcccgcaact tgcgactcag c
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