MG1655
W3110
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Gene Report : prpR
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion 9-1 (LD)  ,  DE(gpt-lac)5  ,  DE(argF-lac)169  ,  OCR36,37-6 (LD 9C::Ap) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  prpR
Related strains
     Strains Search Search strains by gene name:  prpR   Search strains by all related name:  prpR b0330 ECK0328 f528 JW0322 yahP

General information  (Go to Linear View:)
 Gene Name prpR  
 Alternative name b0330,ECK0328,f528,JW0322,yahP  
 Location, Length 346,081 - 347,667 (  -  ) ;   7.46 min ; 1587 (bp) ,   528 (aa) Go to Linear View
 Product propionate catabolism operon regulatory protein  
 Operon Name prpR  
 Note regulator for prp operon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0019395 - fatty acid oxidation; GO_process: GO:0006350 - transcription  
 Function regulator; Not classified  
 Gene Ontology GO:0000156 ; two-component response regulator activity ( prpR )
GO:0000160 ; two-component signal transduction system (phosphorelay) ( prpR )
GO:0000166 ; nucleotide binding ( prpR )
GO:0003677 ; DNA binding ( prpR )
GO:0003700 ; transcription factor activity ( prpR )
GO:0005515 ; protein binding ( prpR )
GO:0005524 ; ATP binding ( prpR )
GO:0005622 ; intracellular ( prpR )
GO:0005737 ; cytoplasm ( prpR )
GO:0006350 ; transcription ( prpR )
GO:0006355 ; regulation of transcription, DNA-dependent ( prpR )
GO:0008134 ; transcription factor binding ( prpR )
GO:0017111 ; nucleoside-triphosphatase activity ( prpR )
GO:0019629 ; propionate catabolic process, 2-methylcitrate cycle ( prpR )
 PID 1786524  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) PRPR_ECOLI ( P77743 )
    -  Protein name Propionate catabolism operon regulatory protein.  
    -  Synonyms  
    -  Gene name Name=prpR; OrderedLocusNames=b0330;  

 Linear View (Whole Mode)
View Location
   335.0  –  360.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP prpR (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of A Sigma54-Activator Suggests The Mechanism For The Conformational Switch Necessary For Sigma54 Binding  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Propionate catabolism operon regulatory protein  
         PSI-BLAST Chaperone clpB
    nr     (database updated : 2007.02.20 )
         BLAST DNA-binding transcriptional activator [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    TRYPSIN_HIS    SIGMA54_INTERACT_2    SIGMA54_INTERACT_3     

Other Cross-Reference
    COG COG1221KT  COG3829KT 
    EcoCyc prpR 

MMBR References
Arch Microbiol. 1997;168(5):428-36.
Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria.
Textor S, Wendisch VF, De Graaf AA, Muller U, Linder MI, Linder D, Buckel W. ( 9325432 )

Sequences
Amino acid
FASTA format 
0001 MAHPPRLNDD KPVIWTVSVT RLFELFRDIS LEFDHLANIT PIQLGFEKAV TYIRKKLANE RCDAIIAAGS 
0071 NGAYLKSRLS VPVILIKPSG YDVLQALAKA GKLTSSIGVV TYQETIPALV AFQKTFNLRL DQRSYITEED 
0141 ARGQINELKA NGTEAVVGAG LITDLAEEAG MTGIFIYSAA TVRQAFSDAL DMTRMSLRHN THDATRNALR 
0211 TRYVLGDMLG QSPQMEQVRQ TILLYARSSA AVLIEGETGT GKELAAQAIH REYFARHDAR QGKKSHPFVA 
0281 VNCGAIAESL LEAELFGYEE GAFTGSRRGG RAGLFEIAHG GTLFLDEIGE MPLPLQTRLL RVLEEKEVTR 
0351 VGGHQPVPVD VRVISATHCN LEEDMQQGRF RRDLFYRLSI LRLQLPPLRE RVADILPLAE SFLKVSLAAL 
0421 SAPFSAALRQ GLQASETVLL HYDWPGNIRE LRNMMERLAL FLSVEPTPDL TPQFMQLLLP ELARESAKTP 
0491 APRLLTPQQA LEKFNGDKTA AANYLGISRT TFWRRLKS
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             tttcagttaa cgtttcaggc aatgtttcac 
-070 cgcgtttcat tgcaacaatt atgaaacaag actaaaccca atattcggtt tcttaacttt gcggtgcgct 
0001 atggcacatc caccacggct taatgacgac aaaccggtta tctggacggt atctgtaacg cgcctgttcg 
0071 agctgtttcg cgatatcagc ctcgagtttg atcacctggc gaacattacc cctattcagc ttggctttga 
0141 aaaagcagtg acctacatcc gcaagaaact ggcaaacgaa cgctgtgacg ccatcatcgc ggctggctct 
0211 aacggcgcgt acctgaaaag ccgcctgtca gtgccagtta ttttgattaa accgagcggc tacgatgtgt 
0281 tacaggcact ggcaaaagcc ggaaaactca cctcttctat cggcgttgtc acctatcagg aaaccattcc 
0351 agcgctggtg gcgtttcaaa aaacctttaa tttgcgcctc gaccaacgta gctacattac cgaggaagac 
0421 gcacgcgggc agattaacga gctaaaagct aacggcaccg aagcggtggt cggcgcaggg ctgattaccg 
0491 atttggcaga agaagccgga atgaccggaa tttttatcta ttccgccgcc accgtgcgcc aggcgttcag 
0561 cgatgcgctg gatatgacgc gcatgtcgtt acgccataac actcacgatg ccacccgcaa cgccctgcgt 
0631 actcgttacg tgctgggcga tatgctcggt caatcaccac agatggaaca agtacggcag actattttgc 
0701 tgtatgcccg ctccagtgcg gcggtgttga ttgaggggga aacggggacg ggcaaagagc tggcggccca 
0771 ggcgattcat cgggaatatt ttgcccgcca cgatgcgcga cagggcaaaa agtcgcatcc gtttgttgcc 
0841 gtcaactgcg gggcgattgc cgaatcgctg ctggaagcag aactgtttgg ctatgaggaa ggggcgttta 
0911 ccggctcgcg acgcggaggt cgcgccgggc tgttcgaaat tgcccacggc ggtacgctgt ttctggatga 
0981 gattggcgaa atgccgctac ctttgcagac ccggctgctg cgggtgctgg aagaaaaaga ggtcacccgc 
1051 gtcggcgggc atcagcctgt tccggtagat gtacgggtca ttagcgccac tcactgcaat ctggaagaag 
1121 atatgcagca aggacgtttt cgccgtgatc tgttttatcg gctgagtatt ttgcgtctgc aattgccacc 
1191 actgcgcgag cgggtggcgg atattcttcc gctggcggaa agctttttga aagtgtctct ggcggcgctc 
1261 tccgccccat tttctgctgc attacgccag gggttacagg caagtgaaac tgtgctgctg cactacgact 
1331 ggccaggcaa tattcgtgaa ctgcgcaata tgatggaacg actggcgctg tttttaagtg tggaaccgac 
1401 gccggattta acgccgcagt ttatgcaact gctactgccg gaactggcgc gcgagtcggc gaaaactccc 
1471 gctccacgct tactgacacc acaacaggca ctggagaaat ttaatggcga taaaacagca gcggcgaatt 
1541 atttaggcat cagccggacg acgttctggc ggcggctgaa aagctgaact gccgaatgca gcgcgaacgc 
1611 tttatccggc ataaatttca atagatgatc accgataaac ttacgcatcg gagatgttta cataggattc 
1681 agaatta