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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1993;175(21):6881-9.
Organization and nucleotide sequences of the genes encoding the biotin carboxyl carrier protein and biotin carboxylase protein of Pseudomonas aeruginosa acetyl coenzyme A carboxylase.
Best EA, Knauf VC.
(
7693652
)
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Deletion
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OCL24,25-1
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
accC
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Related strains
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Strains Search
|
Search strains by gene name:
accC
Search strains by all related name:
accC b3256 ECK3243 fabG JW3224 o449
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General information (Go to Linear View: )
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Gene Name
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accC
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Alternative name
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b3256,ECK3243,fabG,JW3224,o449
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Location, Length
|
3,403,939 - 3,405,288
(
+
)
;
73.37
min
;
1350
(bp) ,
449
(aa)
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Product
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acetyl-CoA carboxylase, biotin carboxylase subunit
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Operon Name
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accBC
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Note
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acetyl CoA carboxylase, biotin carboxylase subunit; GO_component: GO:0005737 - cytoplasm
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Function
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enzyme; Fatty acid and phosphatidic acid biosynthesis
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Gene Ontology
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GO:0000166
;
nucleotide binding ( accC )
GO:0003824
;
catalytic activity ( accC )
GO:0003824
;
catalytic activity ( fabG )
GO:0003989
;
acetyl-CoA carboxylase activity ( accC )
GO:0004075
;
biotin carboxylase activity ( accC )
GO:0004316
;
3-oxoacyl-[acyl-carrier-protein] reductase activity ( fabG )
GO:0005488
;
binding ( fabG )
GO:0005524
;
ATP binding ( accC )
GO:0006633
;
fatty acid biosynthetic process ( accC )
GO:0006633
;
fatty acid biosynthetic process ( fabG )
GO:0008152
;
metabolic process ( accC )
GO:0008152
;
metabolic process ( fabG )
GO:0008610
;
lipid biosynthetic process ( accC )
GO:0008610
;
lipid biosynthetic process ( fabG )
GO:0009374
;
biotin binding ( accC )
GO:0016491
;
oxidoreductase activity ( fabG )
GO:0016874
;
ligase activity ( accC )
GO:0051287
;
NAD binding ( fabG )
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PID
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1789654
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EC number
(KEGG Pathway)
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6.3.4.14
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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accC
(
EG10276
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show details
[
4
more]
)
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Entry name(Acc.no)
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ACCC_ECOLI
(
P24182
)
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- Protein name
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Biotin carboxylase
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- Synonyms
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EC 6.3.4.14, A subunit of acetyl-CoA carboxylase, EC 6.4.1.2, ACC
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- Gene name
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Name=accC; Synonyms=fabG; OrderedLocusNames=b3256;
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MMBR References
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Proc Natl Acad Sci U S A. 1991;88:9730-9733
Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit.
Kondo, H., K. Shiratsuchi, T. Yoshimoto, T. Masuda, A. Kitazono, D. Tsuru, M. Anai, M. Sekiguchi, and T. Tanabe.
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J Bacteriol. 1993;175:332-340
Growth rate regulation of Escherichia coli acetyl coenzyme A carboxylase, which catalyzes the first committed step of lipid biosynthesis.
Li, S.-J., and J. E. Cronan, Jr.
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J Bacteriol. 1992;174(23):7873-4.
Physical locations of genes in the rne (ams)-rpmF-plsX-fab region of the Escherichia coli K-12 chromosome.
Oh W, Larson TJ.
(
1447160
)
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| Sequences |
Amino acid
FASTA format
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0001 MLDKIVIANR GEIALRILRA CKELGIKTVA VHSSADRDLK HVLLADETVC IGPAPSVKSY LNIPAIISAA
0071 EITGAVAIHP GYGFLSENAN FAEQVERSGF IFIGPKAETI RLMGDKVSAI AAMKKAGVPC VPGSDGPLGD
0141 DMDKNRAIAK RIGYPVIIKA SGGGGGRGMR VVRGDAELAQ SISMTRAEAK AAFSNDMVYM EKYLENPRHV
0211 EIQVLADGQG NAIYLAERDC SMQRRHQKVV EEAPAPGITP ELRRYIGERC AKACVDIGYR GAGTFEFLFE
0281 NGEFYFIEMN TRIQVEHPVT EMITGVDLIK EQLRIAAGQP LSIKQEEVHV RGHAVECRIN AEDPNTFLPS
0351 PGKITRFHAP GGFGVRWESH IYAGYTVPPY YDSMIGKLIC YGENRDVAIA RMKNALQELI IDGIKTNVDL
0421 QIRIMNDENF QHGGTNIHYL EKKLGLQEK
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GAAGCGGACA AATCCGGTAC CGTGAAAGCA
-070 ATTCTGGTCG AAAGTGGACA ACCGGTAGAA TTTGACGAGC CGCTGGTCGT CATCGAGTAA CGAGGCGAAC
0001 atgctggata aaattgttat tgccaaccgc ggcgagattg cattgcgtat tcttcgtgcc tgtaaagaac
0071 tgggcatcaa gactgtcgct gtgcactcca gcgcggatcg cgatctaaaa cacgtattac tggcagatga
0141 aacggtctgt attggccctg ctccgtcagt aaaaagttat ctgaacatcc cggcaatcat cagcgccgct
0211 gaaatcaccg gcgcagtagc aatccatccg ggttacggct tcctctccga gaacgccaac tttgccgagc
0281 aggttgaacg ctccggcttt atcttcattg gcccgaaagc agaaaccatt cgcctgatgg gcgacaaagt
0351 atccgcaatc gcggcgatga aaaaagcggg cgtcccttgc gtaccgggtt ctgacggccc gctgggcgac
0421 gatatggata aaaaccgtgc cattgctaaa cgcattggtt atccggtgat tatcaaagcc tccggcggcg
0491 gcggcggtcg cggtatgcgc gtagtgcgcg gcgacgctga actggcacaa tccatctcca tgacccgtgc
0561 ggaagcgaaa gctgctttca gcaacgatat ggtttacatg gagaaatacc tggaaaatcc tcgccacgtc
0631 gagattcagg tactggctga cggtcagggc aacgctatct atctggcgga acgtgactgc tccatgcaac
0701 gccgccacca gaaagtggtc gaagaagcgc cagcaccggg cattaccccg gaactgcgtc gctacatcgg
0771 cgaacgttgc gctaaagcgt gtgttgatat cggctatcgc ggtgcaggta ctttcgagtt cctgttcgaa
0841 aacggcgagt tctatttcat cgaaatgaac acccgtattc aggtagaaca cccggttaca gaaatgatca
0911 ccggcgttga cctgatcaaa gaacagctgc gtatcgctgc cggtcaaccg ctgtcgatca agcaagaaga
0981 agttcacgtt cgcggccatg cggtggaatg tcgtatcaac gccgaagatc cgaacacctt cctgccaagt
1051 ccgggcaaaa tcacccgttt ccacgcacct ggcggttttg gcgtacgttg ggagtctcat atctacgcgg
1121 gctacaccgt accgccgtac tatgactcaa tgatcggtaa gctgatttgc tacggtgaaa accgtgacgt
1191 ggcgattgcc cgcatgaaga atgcgctgca ggagctgatc atcgacggta tcaaaaccaa cgttgatctg
1261 cagatccgca tcatgaatga cgagaacttc cagcatggtg gcactaacat ccactatctg gagaaaaaac
1331 tcggtcttca ggaaaaataa GACTGCTAAA GCGTCAAAAG GCCGGATTTT CCGGCCTTTT TTATTACTGG
1401 GGATCGACAA CCCCCATAAG GTACAATCCC CGCTTTCTTC ACCCATCAGG
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