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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
|
Antimicrob Agents Chemother. 1998;42(1):88-93.
Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli.
Vedantam G, Guay GG, Austria NE, Doktor SZ, Nichols BP.
(
9449266
)
|
|
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Deletion
|
OCL29,30-6 (AK4-11 / BK5-11)
(D)
,
OCL29-6
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
folP
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Related strains
|
|
Strains Search
|
Search strains by gene name:
folP
Search strains by all related name:
folP b3177 dhpS ECK3166 f297 JW3144
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General information (Go to Linear View: )
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Gene Name
|
folP
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Alternative name
|
b3177,dhpS,ECK3166,f297,JW3144
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Location, Length
|
3,322,085 - 3,322,933
(
-
)
;
71.60
min
;
849
(bp) ,
282
(aa)
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Product
|
7,8-dihydropteroate synthase
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Operon Name
|
folP-glmM
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Note
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GO_process: GO:0046656 - folic acid biosynthetic process
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Function
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enzyme; Biosynthesis of cofactors, carriers: Folic acid
|
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Gene Ontology
|
GO:0004156
;
dihydropteroate synthase activity ( folP )
GO:0009396
;
folic acid and derivative biosynthetic process ( folP )
GO:0016740
;
transferase activity ( folP )
GO:0044237
;
cellular metabolic process ( folP )
GO:0046656
;
folic acid biosynthetic process ( folP )
GO:0046677
;
response to antibiotic ( folP )
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PID
|
87082224
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EC number
(KEGG Pathway)
|
2.5.1.15
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
|
folP
(
EG50011
)
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Number of removed
|
0 aa cleaved
|
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SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
DHPS_ECOLI
(
P26282
;
P78110
)
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- Protein name
|
Dihydropteroate synthase
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- Synonyms
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EC 2.5.1.15, DHPS, Dihydropteroate pyrophosphorylase
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- Gene name
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OrderedLocusNames=b3177, c3933, SF3217, S3435;
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MMBR References
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J Bacteriol. 1979;137(1):129-36.
Characterization of mutationally altered dihydropteroate synthase and its ability to form a sulfonamide-containing dihydrofolate analog.
Swedberg G, Castensson S, Skold O.
(
368012
)
|
J Bacteriol. 1993;175(23):7743-4.
The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome.
Dallas WS, Dev IK, Ray PH.
(
8244950
)
|
J Bacteriol. 1992;174:5961-5970
Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100.
Dallas, W. S., J. E. Gowen, P. H. Ray, M. J. Cox, and I. K. Dev.
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| Sequences |
Amino acid
FASTA format
|
0001 MKLFAQGTSL DLSHPHVMGI LNVTPDSFSD GGTHNSLIDA VKHANLMINA GATIIDVGGE STRPGAAEVS
0071 VEEELQRVIP VVEAIAQRFE VWISVDTSKP EVIRESAKVG AHIINDIRSL SEPGALEAAA ETGLPVCLMH
0141 MQGNPKTMQE APKYDDVFAE VNRYFIEQIA RCEQAGIAKE KLLLDPGFGF GKNLSHNYSL LARLAEFHHF
0211 NLPLLVGMSR KSMIGQLLNV GPSERLSGSL ACAVIAAMQG AHIIRVHDVK ETVEAMRVVE ATLSAKENKR
0281 YE
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gcgacaagta agttcccgca tcagatgact
-070 gtatttgtac cgaaaacccc ggggcgtgct ccggggtttt ttcttatcaa ttcataccag ggataacatc
0001 atgaaactct ttgcccaggg tacttcactg gaccttagcc atcctcacgt aatggggatc ctcaacgtca
0071 cgcctgattc cttttcggat ggtggcacgc ataactcgct gatagatgcg gtgaaacatg cgaatctgat
0141 gatcaacgct ggcgcgacga tcattgacgt tggtggcgag tccacgcgcc caggggcggc ggaagttagc
0211 gttgaagaag agttgcaacg tgttattcct gtggttgagg caattgctca acgcttcgaa gtctggatct
0281 cagtcgatac atccaaacca gaagtcatcc gtgagtcagc gaaagttggc gctcacatta ttaatgatat
0351 ccgctccctt tccgaacctg gcgctctgga ggcggctgca gaaaccggtt taccggtttg tctgatgcat
0421 atgcagggaa atccaaaaac catgcaggaa gctccgaagt atgacgatgt ctttgcagaa gtgaatcgct
0491 actttattga gcaaatagca cgttgcgagc aggcgggtat cgcaaaagag aaattgttgc tcgaccccgg
0561 attcggtttc ggtaaaaatc tctcccataa ctattcatta ctggcgcgcc tggctgaatt tcaccatttc
0631 aacctgccgc tgttggtggg tatgtcacga aaatcgatga ttgggcagct gctgaacgtg gggccgtccg
0701 agcgcctgag cggtagtctg gcctgtgcgg tcattgccgc aatgcaaggc gcgcacatca ttcgtgttca
0771 tgacgtcaaa gaaaccgtag aagcgatgcg ggtggtggaa gccactctgt ctgcaaagga aaacaaacgc
0841 tatgagtaat cgtaaatatt tcggtaccga tgggattcgt ggtcgtgtag gggatgcgcc gatcacacct
0911 gattttgtgc ttaagctggg ttgggccgcg ggtaaagtg
|
