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PEC Original Annotations
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Essentiality
|
|
Class
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non-essential
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References (PMID)
|
|
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Deletion
|
9-1
(LD)
,
DE(gpt-lac)5
,
DE(argF-lac)169
,
OCR36,37-6 (LD 9C::Ap)
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
betA
|
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Related strains
|
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Strains Search
|
Search strains by gene name:
betA
Search strains by all related name:
betA b0311 ECK0309 JW0303
|
General information (Go to Linear View: )
|
|
Gene Name
|
betA
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|
Alternative name
|
b0311,ECK0309,JW0303
|
|
Location, Length
|
324,801 - 326,471
(
-
)
;
7.00
min
;
1671
(bp) ,
556
(aa)
|
|
Product
|
choline dehydrogenase, a flavoprotein
|
|
Operon Name
|
betIBA
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Note
|
GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006578 - betaine biosynthetic process; GO_process: GO:0006970 - response to osmotic stress
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|
Function
|
enzyme; Osmotic adaptation
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Gene Ontology
|
GO:0005515
;
protein binding ( betA )
GO:0005886
;
plasma membrane ( betA )
GO:0006066
;
alcohol metabolic process ( betA )
GO:0006950
;
response to stress ( betA )
GO:0008812
;
choline dehydrogenase activity ( betA )
GO:0016020
;
membrane ( betA )
GO:0016491
;
oxidoreductase activity ( betA )
GO:0016614
;
oxidoreductase activity, acting on CH-OH group of donors ( betA )
GO:0019285
;
glycine betaine biosynthetic process from choline ( betA )
GO:0050660
;
FAD binding ( betA )
|
|
PID
|
1786503
|
EC number
(KEGG Pathway)
|
1.1.99.1
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
BETA_ECOLI
(
P17444
;
P77861
)
|
|
- Protein name
|
Choline dehydrogenase
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- Synonyms
|
EC 1.1.99.1, CHD, CDH
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|
- Gene name
|
Name=betA; OrderedLocusNames=b0311;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
|
betA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Glucose Oxidase From Penicillium Amagasakiense
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Choline dehydrogenase
|
|
PSI-BLAST
|
Choline dehydrogenase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
choline dehydrogenase [Escherichia coli K12]
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|
Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
|
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PROSITE
|
ASN_GLYCOSYLATION
GLYCOSAMINOGLYCAN
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
GMC_OXRED_1
GMC_OXRED_2
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MMBR References
|
J Gen Microbiol. 1988;134(6):1737-46.
Molecular cloning, physical mapping and expression of the bet genes governing the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Andresen PA, Kaasen I, Styrvold OB, Boulnois G, Strom AR.
(
3065456
)
|
Mol Microbiol. 1991;5(5):1049-64.
DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Lamark T, Kaasen I, Eshoo MW, Falkenberg P, McDougall J, Strom AR.
(
1956285
)
|
J Bacteriol. 1986;165(3):856-63.
Selection, mapping, and characterization of osmoregulatory mutants of Escherichia coli blocked in the choline-glycine betaine pathway.
Styrvold OB, Falkenberg P, Landfald B, Eshoo MW, Bjornsen T, Strom AR.
(
3512526
)
|
Gene. 1991;103(1):45-52.
Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH.
Boyd LA, Adam L, Pelcher LE, McHughen A, Hirji R, Selvaraj G.
(
1879697
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MQFDYIIIGA GSAGNVLATR LTEDPNTSVL LLEAGGPDYR FDFRTQMPAA LAFPLQGKRY NWAYETEPEP
0071 FMNNRRMECG RGKGLGGSSL INGMCYIRGN ALDLDNWAQE PGLENWSYLD CLPYYRKAET RDMGENDYHG
0141 GDGPVSVTTS KPGVNPLFEA MIEAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPQGRRAST ARGYLDQAKS
0211 RPNLTIRTHA MTDHIIFDGK RAVGVEWLEG DSTIPTRATA NKEVLLCAGA IASPQILQRS GVGNAELLAE
0281 FDIPLVHELP GVGENLQDHL EMYLQYECKE PVSLYPALQW WNQPKIGAEW LFGGTGVGAS NHFEAGGFIR
0351 SREEFAWPNI QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVRIK SRDPHQHPAI LFNYMSHEQD
0421 WQEFRDAIRI TREIMHQPAL DQYRGREISP GVECQTDEQL DEFVRNHAET AFHPCGTCKM GYDEMSVVDG
0491 EGRVHGLEGL RVVDASIMPQ IITGNLNATT IMIGEKIADM IRGQEALPRS TAGYFVANGM PVRAKK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 cgcgagaacg gcgtgatgac gctccagagt
-070 tacacccagg tgaagtccat ccaggttgag atggctaaat tccagtccat attctaacca ggaggtttat
0001 ttgcaatttg actacatcat tattggtgcc ggctcagccg gcaacgttct cgctacccgt ctgactgaag
0071 atccgaatac ctccgtgctg ctgcttgaag cgggcggccc ggactatcgc tttgacttcc gcacccagat
0141 gcccgctgcc ctggcattcc cgctacaggg taaacgctac aactgggcct atgaaacgga acctgaaccg
0211 tttatgaata accgccgcat ggagtgcgga cgcggtaaag gtctgggtgg atcgtcgctg atcaacggca
0281 tgtgctacat ccgtggcaat gcgctggatc tcgataactg ggcgcaagaa cccggtctgg agaactggag
0351 ctacctcgac tgcctgccct actaccgcaa ggccgagact cgcgatatgg gtgaaaacga ctatcacggc
0421 ggtgatggcc cggtgagcgt cactacctcc aaacccggcg tcaatccgct gtttgaagcg atgattgaag
0491 cgggcgtgca ggcgggctac ccgcgcacgg acgatctcaa cggttatcag caggaaggtt ttggtccgat
0561 ggatcgcacc gtcacgccgc agggccgtcg cgccagcacc gcgcgtggct atctcgatca ggccaaatcg
0631 cgtcctaacc tgaccattcg tactcacgct atgaccgatc acatcatttt tgacggcaaa cgcgcggtgg
0701 gcgtcgaatg gctggaaggc gacagcacca tcccaacccg cgcaacggcc aacaaagaag tgctgttatg
0771 tgcaggcgcg attgcctcac cgcagatcct gcaacgctcc ggcgtcggca acgctgaact gctggcggag
0841 tttgatattc cgctggtgca tgaattaccc ggcgtcggcg aaaatcttca ggatcatctg gagatgtatc
0911 tgcaatatga gtgcaaagaa ccggtttccc tctaccctgc cctgcagtgg tggaaccagc cgaaaatcgg
0981 tgcggagtgg ctgtttggcg gcactggcgt tggtgccagc aaccactttg aagcaggtgg atttattcgc
1051 agccgtgagg aatttgcgtg gccgaatatt cagtaccatt tcctgccagt agcgattaac tataacggct
1121 cgaatgcagt gaaagagcac ggtttccagt gccacgtcgg ctcaatgcgc tcgccaagcc gtgggcatgt
1191 gcggattaaa tcccgcgacc cgcaccagca tccggcgatt ctgtttaact acatgtcgca cgagcaggac
1261 tggcaggagt tccgcgacgc aattcgcatc acccgcgaga tcatgcatca acccgcgctg gatcagtatc
1331 gtggccgcga aatcagcccc ggtgtcgaat gccagacgga tgaacagctc gatgagttcg tgcgtaacca
1401 cgccgaaacc gccttccatc cgtgcggtac ctgcaaaatg ggttacgacg agatgtccgt ggttgacggc
1471 gaaggccgcg tacacgggtt agaaggcctg cgtgtggtgg atgcgtcgat tatgccgcag attatcaccg
1541 ggaatttgaa cgccacgaca attatgattg gcgagaaaat agcggatatg attcgtggac aggaagcgct
1611 gccgaggagc acggcgggat attttgtggc aaatgggatg ccggtgagag cgaaaaaatg agtcgtgatg
1681 tgaactaacg caggaaccga tcagattgag agttaccgtt ccagagaggg ggaccgaatc cttatataaa
1751 cactgaggta actctcatgc t
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