MG1655
W3110
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Gene Report : ribB
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
J Bacteriol. 1991;173(19):5999-6008.
The Escherichia coli htrP gene product is essential for bacterial growth at high temperatures: mapping, cloning, sequencing, and transcriptional regulation of htrP.
Raina S, Mabey L, Georgopoulos C. ( 1917833 )
     Deletion OCL36(PC3,OCL35-1) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  ribB
Related strains
     Strains Search Search strains by gene name:  ribB   Search strains by all related name:  ribB b3041 ECK3032 htrP JW3009 luxH

General information  (Go to Linear View:)
 Gene Name ribB  
 Alternative name b3041,ECK3032,htrP,JW3009,luxH  
 Location, Length 3,181,835 - 3,182,488 (  -  ) ;   68.58 min ; 654 (bp) ,   217 (aa) Go to Linear View
 Product 3,4-dihydroxy-2-butanone-4-phosphate synthase  
 Operon Name sroG-ribB  
 Note 3,4 dihydroxy-2-butanone-4-phosphate synthase  
 Function enzyme; Biosynthesis of cofactors, carriers: Riboflavin  
 Gene Ontology GO:0000287 ; magnesium ion binding ( ribB )
GO:0005515 ; protein binding ( ribB )
GO:0005886 ; plasma membrane ( ribB )
GO:0006950 ; response to stress ( ribB )
GO:0008686 ; 3,4-dihydroxy-2-butanone-4-phosphate synthase activity ( ribB )
GO:0009231 ; riboflavin biosynthetic process ( ribB )
GO:0016020 ; membrane ( ribB )
GO:0016829 ; lyase activity ( ribB )
GO:0030145 ; manganese ion binding ( ribB )
GO:0046872 ; metal ion binding ( ribB )
 PID 1789420  
 EC number
  (KEGG Pathway)   		 
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene ribB ( EG10465 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details [ 1 more] )
  botton Entry name(Acc.no) RIBB_ECOLI ( P24199 )
    -  Protein name 3,4-dihydroxy-2-butanone 4-phosphate synthase  
    -  Synonyms DHBP synthase  
    -  Gene name OrderedLocusNames=b3041, z4399, ECs3929, SF3081, S3286;  

 Linear View (Whole Mode)
View Location
   3170.0  –  3195.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP ribB (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Solution Structure Of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Of Riboflavin Biosynthesis  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)  
         PSI-BLAST 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
    nr     (database updated : 2007.02.20 )
         BLAST 3,4-dihydroxy-2-butanone 4-phosphate synthase [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    EcoCyc ribB 

MMBR References
Genetika. 1983;19(9):1419-25.
[3 linkage groups of the genes of riboflavin biosynthesis in Escherichia coli]
Bandrin SV, Rabinovich PM, Stepanov AI. ( 6315532 )
Sov. Genet. (Engl. Transl. Genetika) 1984;19:1103-1109.
Three linkage groups of genes for riboflavin biosynthesis.
Bandrin, S. V., P. M. Rabinovich, and A. I. Stepanov.
J Bacteriol. 1991;173(19):5999-6008.
The Escherichia coli htrP gene product is essential for bacterial growth at high temperatures: mapping, cloning, sequencing, and transcriptional regulation of htrP.
Raina S, Mabey L, Georgopoulos C. ( 1917833 )
J Bacteriol. 1992;174:4050-4056
Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli.
Richter, G., R. Volk, C. Krieger, H.-W. Lahm, U. Rothlisberger, and A. Bacher.
Cytol. Genet. 1983;17:57-59.
Localization of genes coding cyclohexrolase [cyclohydrolase] II and riboflavin synthase on the Escherichia coli K-12 chromosome.
Teslyar, G. E., and G. M. Shavlovskii.

Sequences
Amino acid
FASTA format 
0001 MNQTLLSSFG TPFERVENAL AALREGRGVM VLDDEDRENE GDMIFPAETM TVEQMALTIR HGSGIVCLCI 
0071 TEDRRKQLDL PMMVENNTSA YGTGFTVTIE AAEGVTTGVS AADRITTVRA AIADGAKPSD LNRPGHVFPL 
0141 RAQAGGVLTR GGHTEATIDL MTLAGFKPAG VLCELTNDDG TMARAPECIE FANKHNMALV TIEDLVAYRQ 
0211 AHERKAS
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             ctgtcgggca tggacccgct cacgttattt 
-070 tggctatatg ccgccactcc taagactgcc ctgattctgg taaccataat tttagtgagg tttttttacc 
0001 atgaatcaga cgctactttc ctcttttggt acgcctttcg aacgtgttga aaatgcactg gctgcgctgc 
0071 gtgaaggacg cggtgtaatg gtgcttgatg atgaagaccg tgaaaacgaa ggtgatatga tcttcccggc 
0141 agaaaccatg actgttgagc agatggcgct gaccattcgc cacggtagcg gtattgtttg cctgtgcatt 
0211 actgaagatc gccgtaaaca actcgatctg ccaatgatgg tagaaaataa caccagcgcc tatggcaccg 
0281 gttttaccgt gaccattgaa gcagctgaag gtgtgactac cggtgtttct gccgctgacc gtattacgac 
0351 cgttcgcgca gcgattgccg atggcgcaaa accgtcagat ctgaatcgtc ctggccacgt tttcccactt 
0421 cgcgctcagg caggtggtgt actgacgcgt ggcggtcata ctgaagcaac tattgatctg atgacgctgg 
0491 caggctttaa accggctggt gtactgtgtg agctgactaa tgacgatggc acgatggcgc gtgcaccaga 
0561 gtgtattgag tttgccaata aacacaatat ggcgctcgtg actattgaag acctggtggc ataccgtcag 
0631 gcacatgagc gtaaagccag ctgaaaaccg ctgcttaatt tactgcctta atcaagaaac cgaagttgta 
0701 gcaggcttcg gtttttattt ttccctgcta tgcaagatgt taattccgct tctc