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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
|
OCL40
(D)
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|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
serA
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Related strains
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Strains Search
|
Search strains by gene name:
serA
Search strains by all related name:
serA b2913 ECK2909 JW2880
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General information (Go to Linear View: )
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Gene Name
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serA
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Alternative name
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b2913,ECK2909,JW2880
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Location, Length
|
3,055,200 - 3,056,432
(
-
)
;
65.85
min
;
1233
(bp) ,
410
(aa)
|
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Product
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D-3-phosphoglycerate dehydrogenase
|
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Operon Name
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serA
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Note
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GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006564 - L-serine biosynthetic process
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Function
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enzyme; Amino acid biosynthesis: Serine
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Gene Ontology
|
GO:0003824
;
catalytic activity ( serA )
GO:0004617
;
phosphoglycerate dehydrogenase activity ( serA )
GO:0005488
;
binding ( serA )
GO:0006564
;
L-serine biosynthetic process ( serA )
GO:0008152
;
metabolic process ( serA )
GO:0008652
;
amino acid biosynthetic process ( serA )
GO:0016491
;
oxidoreductase activity ( serA )
GO:0016597
;
amino acid binding ( serA )
GO:0016616
;
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ( serA )
GO:0048037
;
cofactor binding ( serA )
GO:0051287
;
NAD binding ( serA )
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PID
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1789279
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EC number
(KEGG Pathway)
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1.1.1.95
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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serA
(
EG10944
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
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SERA_ECOLI
(
P08328
)
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- Protein name
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D-3-phosphoglycerate dehydrogenase
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- Synonyms
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EC 1.1.1.95, PGDH
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- Gene name
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OrderedLocusNames=b2913, c3494, z4251, ECs3784, SF2898, S3098;
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MMBR References
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J Bacteriol. 1991;173(5):1571
Physical locations of bglA and serA on the Escherichia coli K-12 chromosome.
O'Day K, Lopilato J, Wright A.
(
1999380
)
|
J Biol Chem. 1986;261:12179-12183
The nucleotide sequence of the serA gene of Escherichia coli and the amino acid sequence of the encoded protein, D-3-phosphoglycerate dehydrogenase.
Tobey, K. L., and G. A. Grant.
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J Bacteriol. 1971;106(3):972-82.
Biochemical bases for the antimetabolite action of L-serine hydroxamate.
Tosa T, Pizer LI.
(
4934072
)
|
J Bacteriol. 1996;178:232-239
A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.
Zhao, G., and M. E. Winkler.
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J Biol Chem. 1996;271:23235-23238
The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues.
Al-Rabiee, R., Y. Zhang, and G. A. Grant.
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| Sequences |
Amino acid
FASTA format
|
0001 MAKVSLEKDK IKFLLVEGVH QKALESLRAA GYTNIEFHKG ALDDEQLKES IRDAHFIGLR SRTHLTEDVI
0071 NAAEKLVAIG CFCIGTNQVD LDAAAKRGIP VFNAPFSNTR SVAELVIGEL LLLLRGVPEA NAKAHRGVWN
0141 KLAAGSFEAR GKKLGIIGYG HIGTQLGILA ESLGMYVYFY DIENKLPLGN ATQVQHLSDL LNMSDVVSLH
0211 VPENPSTKNM MGAKEISLMK PGSLLINASR GTVVDIPALC DALASKHLAG AAIDVFPTEP ATNSDPFTSP
0281 LCEFDNVLLT PHIGGSTQEA QENIGLEVAG KLIKYSDNGS TLSAVNFPEV SLPLHGGRRL MHIHENRPGV
0351 LTALNKIFAE QGVNIAAQYL QTSAQMGYVV IDIEADEDVA EKALQAMKAI PGTIRARLLY
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tcgcgacgca aacgttcata ttgccgcaat
-070 attatttttt gatatgttga aaggcggatg caaatccgca cacaacattt caaaagacag gattgggtaa
0001 atggcaaagg tatcgctgga gaaagacaag attaagtttc tgctggtaga aggcgtgcac caaaaggcgc
0071 tggaaagcct tcgtgcagct ggttacacca acatcgaatt tcacaaaggc gcgctggatg atgaacaatt
0141 aaaagaatcc atccgcgatg cccacttcat cggcctgcga tcccgtaccc atctgactga agacgtgatc
0211 aacgccgcag aaaaactggt cgctattggc tgtttctgta tcggaacaaa ccaggttgat ctggatgcgg
0281 cggcaaagcg cgggatcccg gtatttaacg caccgttctc aaatacgcgc tctgttgcgg agctggtgat
0351 tggcgaactg ctgctgctat tgcgcggcgt gccggaagcc aatgctaaag cgcaccgtgg cgtgtggaac
0421 aaactggcgg cgggttcttt tgaagcgcgc ggcaaaaagc tgggtatcat cggctacggt catattggta
0491 cgcaattggg cattctggct gaatcgctgg gaatgtatgt ttacttttat gatattgaaa ataaactgcc
0561 gctgggcaac gccactcagg tacagcatct ttctgacctg ctgaatatga gcgatgtggt gagtctgcat
0631 gtaccagaga atccgtccac caaaaatatg atgggcgcga aagaaatttc actaatgaag cccggctcgc
0701 tgctgattaa tgcttcgcgc ggtactgtgg tggatattcc ggcgctgtgt gatgcgctgg cgagcaaaca
0771 tctggcgggg gcggcaatcg acgtattccc gacggaaccg gcgaccaata gcgatccatt tacctctccg
0841 ctgtgtgaat tcgacaacgt ccttctgacg ccacacattg gcggttcgac tcaggaagcg caggagaata
0911 tcggcctgga agttgcgggt aaattgatca agtattctga caatggctca acgctctctg cggtgaactt
0981 cccggaagtc tcgctgccac tgcacggtgg gcgtcgtctg atgcacatcc acgaaaaccg tccgggcgtg
1051 ctaactgcgc tgaacaaaat cttcgccgag cagggcgtca acatcgccgc gcaatatctg caaacttccg
1121 cccagatggg ttatgtggtt attgatattg aagccgacga agacgttgcc gaaaaagcgc tgcaggcaat
1191 gaaagctatt ccgggtacca ttcgcgcccg tctgctgtac taattcccct tctctgaaaa tcaacgggca
1261 ggtcactgac ttgcccgttt ttttatccct tctccacacc gttgccgcgt tgcgcattct actttgcgag
1331 tct
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